Interpreting the preliminary outcomes of the arrowsmith Programme: a neuroimaging and behavioural study

Weber, Rachel C.; Denyer, Ronan; Yeganeh, Negin Motamed; Maja, Rachel A; Murphy, Meagan; Martin, Stéphanie; Chiu, Larissa; Nguy, Veronique; White, Katherine; Boyd, Lara A.

doi:10.1080/23735082.2019.1674908

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…We used the broad reading score, a cluster score which measures general reading proficiency, as the main predictor of reading ability and functional connectivity. The rs‐fMRI data shown here are a part of a larger study where task‐based fMRI and multicomponent relaxation imaging were also completed; these data are reported elsewhere (Weber et al., 2019).…”

Section: Methodsmentioning

confidence: 99%

Aberrant Cerebellar Resting‐State Functional Connectivity Related to Reading Performance in Struggling Readers

Greeley

Weber

Denyer

et al. 2020

Developmental Science

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Reading is a critical neurodevelopmental skill for school‐aged children, which requires a distributed network of brain regions including the cerebellum. However, we do not know how functional connectivity between the cerebellum and other brain regions contributes to reading. Here we used resting‐state functional connectivity to understand the cerebellum's role in decoding, reading speed, and comprehension in a group of struggling readers (RD) and a group of adolescents and children with typical reading abilities (TD). We observed an increase in functional connectivity between the sensorimotor network and the left angular gyrus, left lateral occipital cortex, and right inferior frontal gyrus in the RD group relative to the TD group. Additionally, functional connectivity between the cerebellum network and the precentral gyrus was decreased and was related to reading fluency in the RD group. Seed‐based analysis revealed increased functional connectivity between crus 1, lobule 6, and lobule 8 of the cerebellum and brain regions related to the default mode network and the motor system for the RD group. We also found associations between reading performance and the functional connectivity between lobule 8 of the cerebellum and the left angular gyrus for both groups, with stronger relationships in the TD group. Specifically, the RD group displayed a positive relationship between functional connectivity, whereas the TD group displayed the opposite relationship. These results suggest that the cerebellum is involved in multiple components of reading performance and that functional connectivity differences observed in the RD group may contribute to poor reading performance.

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Section: Methodsmentioning

confidence: 99%

Aberrant Cerebellar Resting‐State Functional Connectivity Related to Reading Performance in Struggling Readers

Greeley

Weber

Denyer

et al. 2020

Developmental Science

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“…Significantly lower MWF values have been found in children categorized as ‘poor readers’, further supported by a significant positive correlation between MWF and age-standardized reading scores [15]. Recent work also found that students who showed greater improvement in working memory after cognitive intervention had higher baseline MWF [16]. Considered together, these findings suggest a relationship between myelin and learning disability, or conversely, ability.…”

Section: Early Developmentmentioning

confidence: 88%

Update on myelin imaging in neurological syndromes

Balaji¹,

Johnson²,

Dvorak

et al. 2022

Current Opinion in Neurology

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Purpose of reviewMyelin water imaging (MWI) is generally regarded as the most rigorous approach for noninvasive, in-vivo measurement of myelin content, which has been histopathologically validated. As such, it has been increasingly applied to neurological diseases with white matter involvement, especially those affecting myelin. This review provides an overview of the most recent research applying MWI in neurological syndromes.Recent findingsMyelin water imaging has been applied in neurological syndromes including multiple sclerosis, Alzheimer's disease, Huntington's disease, traumatic brain injury, Parkinson's disease, cerebral small vessel disease, leukodystrophies and HIV. These syndromes generally showed alterations observable with MWI, with decreased myelin content tending to correlate with lower cognitive scores and worse clinical presentation. MWI has also been correlated with genetic variation in the APOE and PLP1 genes, demonstrating genetic factors related to myelin health.SummaryMWI can detect and quantify changes not observable with conventional imaging, thereby providing insight into the pathophysiology and disease mechanisms of a diverse range of neurological syndromes.

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Symbol relations training improves cognitive functioning in students with neurodevelopmental disorders

Yeganeh

King

Boyd

et al. 2021

Applied Neuropsychology: Child

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Interpreting the preliminary outcomes of the arrowsmith Programme: a neuroimaging and behavioural study

Cited by 3 publications

References 61 publications

Aberrant Cerebellar Resting‐State Functional Connectivity Related to Reading Performance in Struggling Readers

Aberrant Cerebellar Resting‐State Functional Connectivity Related to Reading Performance in Struggling Readers

Update on myelin imaging in neurological syndromes

Symbol relations training improves cognitive functioning in students with neurodevelopmental disorders

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