2016
DOI: 10.18596/jotcsa.29558
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Interrelation Among Serum Lithium Levels and Bone Metabolism and Some Biochemical Parameters in Pre and Post-Menauposal Women

Abstract: Abstract:The target of this study is to determine the interrelation among serum Li level on bone metabolism (Ca, P, Parathormone, and Vitamin-D), sex and metabolic hormones (estrogen, FSH, LH and TSH), and some biochemical parameters in premenopausal and postmenopausal women. The study is carried out with 10 women, 5 of which is in the premenopausal period. The serum Li levels, bone metabolism indicators (i.e., ALP, Ca, P, Mg, Cu, and Zn) and some biochemical parameters such as serum triglyceride, alkalene pho… Show more

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Cited by 1 publication
(2 citation statements)
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“…This was in agreement with the previous study, 47 which illustrated that the incorporation of Li + into mesoporous silica nanoparticles showed a stimulatory effect on ALP activity and up‐regulated ALP and OCN gene expression in vitro. From another side, lithium (a glycogen synthase kinase‐3 inhibitor) affects the Wnt/β‐catenin signaling which plays an important role in the development and differentiation of bone tissues 48‐50 . The expression of ALP was induced and controlled by Wnt/β‐catenin signal 51 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This was in agreement with the previous study, 47 which illustrated that the incorporation of Li + into mesoporous silica nanoparticles showed a stimulatory effect on ALP activity and up‐regulated ALP and OCN gene expression in vitro. From another side, lithium (a glycogen synthase kinase‐3 inhibitor) affects the Wnt/β‐catenin signaling which plays an important role in the development and differentiation of bone tissues 48‐50 . The expression of ALP was induced and controlled by Wnt/β‐catenin signal 51 …”
Section: Discussionmentioning
confidence: 99%
“…From another side, lithium (a glycogen synthase kinase-3 inhibitor) affects the Wnt/βcatenin signaling which plays an important role in the development and differentiation of bone tissues. [48][49][50] The expression of ALP was induced and controlled by Wnt/β-catenin signal. 51 Clement-Lacorix, et al 52 stated that Li + was improved bone formation in mice through activation of Wnt signal but not mediated by parathyroid hormone.…”
Section: Histological Analysismentioning
confidence: 99%