Interrelations of Synthesis Method, Polyethylene Glycol Coating, Physico-Chemical Characteristics, and Antimicrobial Activity of Silver Nanoparticles

Abstract

Silver nanoparticles (AgNPs) have been found to have extensive biomedical and biological applications. They can be synthesised using chemical and biological methods, and coated by polymer to enhance their stability. Hence, the changes in the physico-chemical characteristics of AgNPs must be scrutinised due to their importance for biological activity. The UV-Visible absorption spectra of polyethylene glycol (PEG) -coated AgNPs displayed a distinctive narrow peak compared to uncoated AgNPs. In addition, High-Resolution Transmission Electron Microscopy analysis revealed that the shapes of all AgNPs, were predominantly spherical, triangular, and rod-shaped. Fourier-Transform Infrared Spectroscopy analysis further confirmed the role of PEG molecules in the reduction and stabilisation of the AgNPs. Moreover, dynamic light scattering analysis also revealed that the polydispersity index values of PEG-coated AgNPs were lower than the uncoated AgNPs, implying a more uniform size distribution. Furthermore, the uncoated and PEG-coated biologically synthesised AgNPs demonstrated antagonisms activities towards tested pathogenic bacteria, whereas no antagonism activity was detected for the chemically synthesised AgNPs. Overall, generalisation on the interrelations of synthesis methods, PEG coating, characteristics, and antimicrobial activity of AgNPs were established in this study.

Polyethylene glycol dictates the therapeutic response (anticancer and wound healing) of silver oxide nanomaterials

“…The crystallite size of silver oxide is 43.39 nm which reduces to 34.56 and 30.43 nm for PEG and Chitosan‐coated silver oxide nanomaterials, respectively. This size reduction is linked with polymer molecules which on attaching to crystals can reduce further growth and also control the morphology such as shape, size, and size distribution of the synthesized nanomaterials 34,35 . In a specific material, there are suitable growth directions along with growth are favored known as preferred orientations.…”

“…This size reduction is linked with polymer molecules which on attaching to crystals can reduce further growth and also control the morphology such as shape, size, and size distribution of the synthesized nanomaterials. 34,35 In a specific material, there are suitable growth directions along with growth are favored known as preferred orientations. The crystalline materials show the tendency to grow in these directions and the texture coefficient is used to determine such directions/planes and calculated by Equation (2).…”

A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus

“…The choice of ligands used to stabilize AgNPs based on steric hindrance include organic polymers, such as poly(vinyl alcohol) (PVA) [ 72 ], poly(vinylidene fluoride) (PVDF) [ 73 ], and polyethylene glycol (PEG) [ 74 ]. The stability of PEG-coated AgNPs and the uncoated AgNPs was investigated in a study by Mohamad-Kasim et al [ 75 ] based on the measurement of polydispersity index (PdI) and zeta potential (ZP) (mV). The results showed that the PDI value of PEG-coated AgNPs was smaller than the uncoated AgNPs, which demonstrated better size distributions of the AgNPs modified with organic polymer ligands.…”

Silver Nanoparticles Stabilized by Oligomeric Hyperbranched Ionic Liquid: Structure and Antimicrobial Properties

“…It is worth noting that today there are many methods of synthesizing nanoparticles of adjustable size, but the problem of controlling their spatial distribution, i.e. stabilizing their surface to prevent further aggregation, remains unsolved [6][7][8][9].…”

“…As an alternative to PVP, polyethylene glycol (PEG) is often used to stabilize silver nanoparticles. In work [9], the authors used chemical and biological methods of synthesis of AgNP using PEG. It was established that the AgNP stabilized by PEG had sizes of 40-47 nm and demonstrated a high antimicrobial activity.…”