Interrupted versus uninterrupted novel oral anticoagulant peri‐implantation of cardiac device: A single‐center randomized prospective pilot trial

Abstract

Despite the paucity of bleeding events, data from this pilot study suggest that uninterrupted NOAC therapy for CIED implantation appears to be as safe as NOAC interruption and does not increase bleeding complications.

Oral anticoagulants in cardiac electronic devices implantation – case and recent publications review

“…In the case of NOAC therapy, data about procedure-related bleeding complications around the time of cardiac device implantation were not enough, so it is recommended to interrupt NOAC therapy before the surgery, without heparin bridging [13] . In March 2018, Ricciardi et al published the first large randomized trial that compares the effects of continuing with interruption NOAC therapy, without heparin bridging before the CIED implantation [21] .…”

Safety and efficacy of uninterrupted versus minimally interrupted periprocedural DOACs for implantation of cardiac devices in patients with AF

“…There was no difference in other bleeding complications. No thrombotic events were observed in either of the two groups …”

“…In this issue of PACE, Ricciardi et al. report a prospective, randomized, single‐center study that aimed to directly compare interrupted versus uninterrupted NOAC therapy in patients with AF before CIED . A total of 101 patients were enrolled in this trial.…”

“…6 versus uninterrupted NOAC therapy in patients with AF before CIED. 7 A total of 101 patients were enrolled in this trial. One clinically significant pocket hematoma occurred in the uninterrupted NOAC group and none in the interrupted group (P = 0.320).…”

“…No thrombotic events were observed in either of the two groups. 7 The authors must be congratulated for designing and conducting this RCT. Despite the fact that this was a well-conducted trial, it is not well specified in the methods of the study which was the indication for OAT in these patients (AF, deep venous thrombosis, or pulmonary embolism).…”