Intersectin multidomain adaptor proteins: Regulation of functional diversity

A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling

“…The Intersectin family is a scaffold protein containing multiple modular domains such as the Eps15 homology, coiled-coil, SH, Dbl homology, and pleckstrin homology domains. Numerous Intersectin-binding proteins have been identified and linked to various biological functions, such as neurodegeneration via the JNK/MAPK pathway (37,38). The GAREM2-Intersectin 1 complex may mediate neuronal function in the brain.…”

Crystal structure of human Intersectin-2L C2 domain

“…ITSN (also known as Ese-1, EHSH-1, Dap-160) is an evolutionarily conserved scaffolding protein found in diverse metazoan organisms ranging from nematodes to mammals [1][2][3]. There are two ITSN genes in mammals, ITSN-1 and ITSN-2, which have high identity in sequence.…”

Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2

“…24 A recent study further suggested that ITSNs play a role in nascent clathrin-coated pit (CCP) assembly. 25 On the other hand, caseine kinase (CK2) is a highly conserved serine/threonine kinase with a broad subcellular localization.…”