Intersession Reliability of Hoffmann Reflex Gain and Presynaptic Inhibition in the Human Soleus Muscle

Hayes, Bradley T.; Hicks-Little, Charlie A.; Harter, Rod A.; Widrick, Jeffrey J.; Hoffman, Mark A.

doi:10.1016/j.apmr.2009.07.023

Cited by 11 publications

(13 citation statements)

References 25 publications

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“…The ratio between the H-reflex and M-wave represents the percentage of depolarized motoneurons in response to Ia-afferent activation (Tucker et al, 2005; Zehr, 2002). Another discrete variable that is often measured is the peak slope of the H-reflex recruitment curve, which is used to estimate the rate of change in motoneuron pool excitability in response to the increase of Ia-afferent input to the motoneuron pool (Christie et al, 2004; Funase et al, 1994a; Hayes et al, 2009). A third discrete variable, which has also been used to estimate the excitability of the lowest threshold motoneurons, is the stimulation intensity or threshold where the H-reflex first appears and the H-reflex recruitment curve begins to increase (Funase et al, 1994b).…”

Section: Introductionmentioning

confidence: 99%

Functional principal component analysis of H-reflex recruitment curves

Kipp

Johnson

Hoffman

2011

Journal of Neuroscience Methods

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The primary purpose of this study was to use Functional Principal Component Analysis (FPCA) to analyze Hoffman-reflex (H-Reflex) recruitment curves. Smoothed and interpolated recruitment curves from 38 participants were used for analysis. Standard methods were used to calculate three discrete variables (i.e, Hmax/Mmax ratio, Hth, Hslp). FPCA was then used to extract principal component functions (PCF’s) from the processed recruitment curves. PCF scores were calculated to determine how much each PCF contributed to an individuals’ recruitment curve. The analysis extracted three PCF’s, and three sets of PCF scores. Correlation analyses and systematic variation in the PCF scores indicated that the scores for the first PCF were primarily correlated to H-reflex threshold (Hth) and that the scores for the second and third PCF’s were correlated to H-reflex magnitude (Hmax/Mmax ratio) and slope (Hslp), respectively. In addition, results from the FPCA indicated that the first PCF explained 56.0% of the variance between all H-reflex recruitment curves, whereas the second and third PCF’s explained 24.1% and 13.0%, respectively. The high correlations indicate FPCA-derived PCF’s capture similar physiological information as the standard discrete variables and suggest that application of FPCA to H-reflex recruitment curves could be used in future studies to complement traditional analyses that investigate excitability of the motoneuron pool.

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Section: Introductionmentioning

confidence: 99%

Functional principal component analysis of H-reflex recruitment curves

Kipp

Johnson

Hoffman

2011

Journal of Neuroscience Methods

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“…These position changes can lead to alterations in the activity of type I afferents, thus affecting the level of PI [4,5,6]. These types of changes are closely associated with the variations in the neural aspects of the monosynaptic reflex pathway.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, presynaptic mechanisms have been proposed to alter the H-reflex without any corresponding effect on the MN pool itself. PI of the Ia afferent and presynaptic suppression of the H-reflex has shown to be affected by the activation of remote muscle afferents [6].…”

Section: Introductionmentioning

confidence: 99%

“…The degree of depression (% depression) of the second H-reflex produced relative to the first H-reflex was compared. that the mechanisms influencing the change in the Hreflex must have been presynaptic in origin [6].…”

Section: Introductionmentioning

confidence: 99%

“…One study examined the intersession reliability of H-reflex gain and PI in the human soleus muscle of healthy subjects [6]. The study found the measures of PI and H-reflex gain (H slope/M slope) to be consistent and reliable day-to-day.…”

Section: Introductionmentioning

confidence: 99%

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Reliability of Presynaptic Inhibition in Patients with Diabetic Peripheral Neuropathy

Palmer

Hong

2012

International Journal of Neuroscience

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There has been rising interest in evaluating spinal reflex activity within the clinical population, however no study has yet investigated the reliability of presynaptic inhibition (PI) on patients with diabetic peripheral neuropathy (DPN). Because neuropathy is closely related to central nervous system modification, it is important to understand the mechanism of spinal reflex activity in the DPN population. Therefore, the purpose of the study was to evaluate the reliability of PI in patients with DPN. Eight participants (58.24 ± 6.38 yrs.) diagnosed with either type I or type II diabetes and peripheral neuropathy were recruited for the study. Each subject's H-reflex was measured using an EMG to elicit and record a series of 10 paired reflex depression trials. Reliability was measured by calculating Intra Class Correlation Coefficients (ICCs) with a 95% confidence interval. The results showed excellent reliability in both intraday (0.94) and interday (0.88) reliability. Therefore, analyzing PI in the central nervous system allows for an accurate evaluation of spinal cord circuitry in a non-invasive manner.

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Modulation of H-reflex and V-wave responses during dynamic balance perturbations

Nevanperä

Walker

et al. 2023

Exp Brain Res

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Motoneuron excitability is possible to measure using H-reflex and V-wave responses. However, it is not known how the motor control is organized, how the H-reflex and V-wave responses modulate and how repeatable these are during dynamic balance perturbations. To assess the repeatability, 16 participants (8 men, 8 women) went through two, identical measurement sessions with ~ 48 h intervals, where maximal isometric plantar flexion (IMVC) and dynamic balance perturbations in horizontal, anterior–posterior direction were performed. Soleus muscle (SOL) neural modulation during balance perturbations were measured at 40, 70, 100 and 130 ms after ankle movement by using both H-reflex and V-wave methods. V-wave, which depicts the magnitude of efferent motoneuronal output (Bergmann et al. in JAMA 8:e77705, 2013), was significantly enhanced as early as 70 ms after the ankle movement. Both the ratio of M-wave-normalized V-wave (0.022–0.076, p < 0.001) and H-reflex (0.386–0.523, p < 0.001) increased significantly at the latency of 70 ms compared to the latency of 40 ms and remained at these levels at latter latencies. In addition, M-wave normalized V-wave/H-reflex ratio increased from 0.056 to 0.179 (p < 0.001). The repeatability of V-wave demonstrated moderate-to-substantial repeatability (ICC = 0.774–0.912) whereas the H-reflex was more variable showing fair-to-substantial repeatability (ICC = 0.581–0.855). As a conclusion, V-wave was enhanced already at 70 ms after the perturbation, which may indicate that increased activation of motoneurons occurred due to changes in descending drive. Since this is a short time-period for voluntary activity, some other, potentially subcortical responses might be involved for V-wave increment rather than voluntary drive. Our results addressed the usability and repeatability of V-wave method during dynamic conditions, which can be utilized in future studies.

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Intersession Reliability of Hoffmann Reflex Gain and Presynaptic Inhibition in the Human Soleus Muscle

Cited by 11 publications

References 25 publications

Functional principal component analysis of H-reflex recruitment curves

Functional principal component analysis of H-reflex recruitment curves

Reliability of Presynaptic Inhibition in Patients with Diabetic Peripheral Neuropathy

Modulation of H-reflex and V-wave responses during dynamic balance perturbations

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