Interstitial Brachytherapy Guided Intensity Modulated Radiation Therapy in Cervical Carcinoma: A Dosimetric Study

Sharma, Dayanand; Subramani, V.; Rath, G.K.; Ganesh, T; Julka, Pramod Kumar; Basu, Kabya; Bahl, Amit; Natanasabapathi, Gopishankar

doi:10.1016/j.ijrobp.2007.07.2133

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…According to Sharma et al ( 10 ), interstitial implantation-guided afterloading radiotherapy is notably superior to conventional afterloading radiotherapy. In interstitial implantation, the radiation dose to the target area is homogeneously distributed with high coverage, reducing the volume and dose of radiation in normal tissues, including the bladder and rectum.…”

Section: Discussionmentioning

confidence: 99%

Intensity-modulated radiotherapy combined with iodine-125 seed implantation in non-central recurrence of cervical cancer: A case report and literature review

Feng¹,

Hu²,

Jin³

et al. 2017

Oncology Letters

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Recurrent cervical cancer is a clinically complex disease that is difficult to treat. There are numerous treatment options, but the results achieved by each are poor. External-beam radiation therapy of the pelvic lymph drainage area, in combination with intracavitary afterloading or the interstitial implantation of a radiation source (i.e., brachytherapy), are the current standard radiotherapy regimens used in high-risk clinical targets. However, there are few reports concerning the use of iodine-125 (125I) seed implantation brachytherapy in recurrent cervical cancer, and the effects of treatment and adverse reactions have not yet been systematically evaluated. In the present study one such case is reported, in which the patient was successfully treated with intensity-modulated radiotherapy (IMRT) in combination with 125I seed implantation. The patient, a 47-year-old woman, was initially diagnosed with International Federation of Gynecology and Obstetrics stage IB1 cervical cancer, and received a radical hysterectomy, left lateral adnexectomy and pelvic lymph node dissection. A follow-up examination 23 months later revealed vaginal invasion and a solitary lump in the cervical stump with a maximum diameter of 38 mm. The patient was subsequently diagnosed with recurrent cervical cancer and was treated with six cycles of docetaxel and nedaplatin chemotherapy, alongside IMRT and interstitial 125I seed implantation. At the point of manuscript submission, the patient's progression-free survival time was 33 months and long-term adverse reactions were acceptable. The response of this patient indicates that 125I seed implantation could be used as a complementary treatment for recurrent cervical cancer and may also prove to be a reliable means for the comprehensive treatment of primary cervical cancer, as the patient had characteristics similar to primary cervical cancer, although this hypothesis could not be confirmed in the present study.

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Section: Discussionmentioning

confidence: 99%

Intensity-modulated radiotherapy combined with iodine-125 seed implantation in non-central recurrence of cervical cancer: A case report and literature review

Feng¹,

Hu²,

Jin³

et al. 2017

Oncology Letters

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“…Alternative means of radiotherapy dose escalation have also been described, including high‐dose‐rate (HDR) brachytherapy13, 14 and external beam radiotherapy approaches15. HDR boost has been prospectively compared with the standard LDR technique, without evidence of compromised disease control or survival13.…”

Section: Discussionmentioning

confidence: 99%

Author's reply: Systematic review of exercise training or percutaneous transluminal angioplasty for intermittent claudication (Br J Surg 2012; 99: 16–28)

Frans

Koelemay

2012

British Journal of Surgery

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Objectives Tandem placement as part of low‐dose‐rate (LDR) brachytherapy boost for cervical cancer may be complicated by uterine perforation. The objective of this study was to describe a 10‐year experience of using intraoperative ultrasound guidance in an attempt to minimize the risk of uterine perforation. Methods Operative and inpatient records were reviewed to identify cases in which intraoperative ultrasound guidance was employed in order to assist tandem placement, and to determine whether clinical or radiographic findings subsequently suggested uterine perforation. Demographic factors were collected in order to determine the baseline risk of perforation within this population. Results Between 1998 and 2008, 71 patients underwent 110 ultrasound‐guided placements of tandem applicators. The median age was 48 (range, 26–88) years, and 20% were older than 60 years. Disease stage was FIGO IB1 (n = 10), IB2 (n = 13), IIA (n = 4), IIB (n = 19), IIIA (n = 2), IIIB (n = 16), IVA (n = 5) and IVB (n = 2). The median gravidity was 3 (range 1–10) and median parity was 3 (range 0–10). Seven patients had a preimplant history of pelvic infection, four had a history of intrauterine contraceptive device use, and 10 had a prior history of Cesarean section delivery. Only one patient experienced infection that may have been attributable to tandem placement‐associated uterine perforation. At median survivor follow‐up of 34 months, 19 patients had died. The estimated 3‐year disease‐free and overall survival rates for the entire population were 60% and 66%, respectively. Conclusions Within the present population, intraoperative ultrasound guidance of tandem placement was associated with no confirmed cases of uterine perforation. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.

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Interstitial Brachytherapy Guided Intensity Modulated Radiation Therapy in Cervical Carcinoma: A Dosimetric Study

Cited by 2 publications

References 14 publications

Intensity-modulated radiotherapy combined with iodine-125 seed implantation in non-central recurrence of cervical cancer: A case report and literature review

Intensity-modulated radiotherapy combined with iodine-125 seed implantation in non-central recurrence of cervical cancer: A case report and literature review

Author's reply: Systematic review of exercise training or percutaneous transluminal angioplasty for intermittent claudication (Br J Surg 2012; 99: 16–28)

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