Interstitial granulomatous dermatitis with plaques

Interstitial granulomatous dermatitis with arthritis

“…Tomasini and Pippione 3 also reported 17 cases with annular plaques. In addition, 4 cases with erythematous plaques with arthritis associated with the clinical and serologic findings of an autoimmune disease had been described by Aloi et al [2][3][4] The arthritis accompanying these skin lesions may appear before, during, or many years after the onset of the cutaneous lesions. The joint involvement is characteristically symmetrical which often includes the fingers, wrists, elbows, and shoulders.…”

“…However, in our case, complete regression of the lesions occurred despite continuing drug intake, suggesting that drug consumption did not play a role in the pathogenesis of the eruption. 3,[6][7][8] Rheumatoid neutrophilic dermatitis (RND) is a rare cutaneous manifestation of severe seronegative rheumatoid arthritis that usually presents as erythematous papules, plaques, and nodules. Cutaneous lesions are asymptomatic, occurring during flares of arthritis, and tend toward spontaneous resolution with improvement of the underlying joint disease.…”

“…However, patients with different clinical pictures have been reported since then. [2][3][4] Herein we describe a case of IGDA presenting with erythematous annular papules and plaques, without the rope sign.…”

Interstitial Granulomatous Dermatitis Associated With the Use of Tumor Necrosis Factor α Inhibitors

“…Patients with the previously mentioned diseases, particularly RA, are known to have granulomatous diathesis. [13][14][15][16] However, the close association between the development of skin lesions after the initiation of anti-TNF-␣ therapy and, most important, the clearance or improvement of the skin lesions on discontinuation of TNF-␣ inhibitors suggests a role for the medication and the development of cutaneous lesions.…”

“…5 Interstitial granulomatous dermatitis (IGD) has been associated with various systemic disorders, most commonly RA, lupus erythematosus, systemic vasculitis, and lymphoproliferative disorders. [11][12][13][14][15] Various names have been used to designate this entity, including IGD with arthritis, atypical granuloma annulare, linear granuloma annulare, and Churg-Strauss granuloma. Clinically, some patients develop linear cords or plaques on the lateral aspect of the trunk or extensor extremities; however, the clinical lesions may be variable.…”