Interstitial Iodine 125 and Concomitant Cisplatin Followed by Hyperfractionated External Beam Irradiation for Malignant Supratentorial Glioma

Fontanesi, James; Clark, W C; Weir, Alva B.; Barry, A.; Kumar, Parvesh; Miller, April D.; Eddy, T.; Tai, Douglas L.; Kun, L.

doi:10.1097/00000421-199310000-00008

Cited by 5 publications

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“…Sometimes radiotherapy was combined with chemotherapy regimens [109,118,125,138] or hyperthermia [145], or was given after seed implantation [108]. …”

Section: Reviewmentioning

confidence: 99%

“…Many different dose combinations of percutaneous radiotherapy and iodine-125 brachytherapy have been given in the primary therapy setting; 45Gy whole brain radiotherapy and 100-280Gy (15-30cGy/h) brachytherapy boost [ 47 ], 59.4Gy (1.8Gy, 5×/week) or 40Gy (2Gy, 2×/day) and a high activity brachytherapy boost of 50Gy [ 137 ], but most percutaneous and temporary seed dose were 60Gy [ 139 , 141 ]. Sometimes radiotherapy was combined with chemotherapy regimens [ 109 , 118 , 125 , 138 ] or hyperthermia [ 145 ], or was given after seed implantation [ 108 ].…”

Section: Reviewmentioning

confidence: 99%

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Iodine-125 brachytherapy for brain tumours - a review

et al. 2012

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Iodine-125 brachytherapy has been applied to brain tumours since 1979. Even though the physical and biological characteristics make these implants particularly attractive for minimal invasive treatment, the place for stereotactic brachytherapy is still poorly defined.An extensive review of the literature has been performed, especially concerning indications, results and complications. Iodine-125 seeds have been implanted in astrocytomas I-III, glioblastomas, metastases and several other tumour entities. Outcome data given in the literature are summarized. Complications are rare in carefully selected patients.All in all, for highly selected patients with newly diagnosed or recurrent primary or metastatic tumours, this method provides encouraging survival rates with relatively low complication rates and a good quality of life.

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“…Sometimes radiotherapy was combined with chemotherapy regimens [109,118,125,138] or hyperthermia [145], or was given after seed implantation [108]. …”

Section: Reviewmentioning

confidence: 99%