Interstitial lung disease after receiving the mRNA-based COVID-19 vaccine tozinameran

Risk of newly diagnosed interstitial lung disease after COVID-19 and impact of vaccination: a nationwide population-based cohort study

“…Although these previous studies demonstrated an association between COVID-19 and ILD, the actual estimated incidence and risk of clinically relevant ILD Another important finding of our study is that COVID-19 vaccination can decrease the risk of post-COVID-19 ILD at the population level, demonstrating the preventive role of COVID-19 vaccination on this disastrous post-COVID-19 complication. However, at the individual level, there have been some concerns that the COVID-19 vaccine could cause or aggravate ILD (33)(34)(35)(36). Although some cases were successfully recovered with corticosteroid treatments (33)(34)(35), one study in which 37% had underlying pre-diagnosed ILD, reported the mortality rate was 15% (35).…”

“…However, at the individual level, there have been some concerns that the COVID-19 vaccine could cause or aggravate ILD (33)(34)(35)(36). Although some cases were successfully recovered with corticosteroid treatments (33)(34)(35), one study in which 37% had underlying pre-diagnosed ILD, reported the mortality rate was 15% (35). Accordingly, based on the findings of a previous study that has demonstrated the safety of the vaccine (37) and our research, maintaining a positive position on COVID-19 vaccination against post-COVID-19 ILD, a balanced understanding of the relationship between COVID-19 vaccination and ILD risk, is needed.…”

Interstitial Lung Disease With Respiratory Failure After COVID-19 mRNA Vaccination

“…We searched for recent reports of COVID-19 mRNA vaccine-related DI-ILD [7][8][9][10][11][12][13][14]. The characteristics of these patients include the appearance of respiratory symptoms soon after vaccination, onset of disease during the first or second vaccination period, high levels of KL-6 and SP-D (range 214-4084 U/mL and 73.1-675.5 ng/mL, respectively), an organizing pneumonia pattern on chest CT, a high percentage of lymphocytes in BAL fluid, and high responsiveness to steroids.…”

COVID-19 and interstitial lung diseases: A multifaceted look at the relationship between the two diseases

“…To date, case-based information has been accumulated, starting with the first case report of vaccine-related ILD induced by an mRNA vaccine [ 174 ]. These cases have consistently shown that ILD occurred within 1-10 days after the first or second shot of the vaccine and sometimes improved spontaneously [ 175 , 176 , 177 ] but sometimes was accompanied by respiratory failure and treated with corticosteroid (methylprednisolone 0.5-1mg/kg and/or pulse therapy) [ 177 , 178 , 179 , 180 , 181 , 182 ]. The major radiological findings are GGO and consolidation represented by an HP or OP pattern [ 175 , 181 ].…”

“…These cases have consistently shown that ILD occurred within 1-10 days after the first or second shot of the vaccine and sometimes improved spontaneously [ 175 , 176 , 177 ] but sometimes was accompanied by respiratory failure and treated with corticosteroid (methylprednisolone 0.5-1mg/kg and/or pulse therapy) [ 177 , 178 , 179 , 180 , 181 , 182 ]. The major radiological findings are GGO and consolidation represented by an HP or OP pattern [ 175 , 181 ]. Histopathological lymphocytic alveolitis, or OP, was proven in some of these cases [ 181 , 182 ].…”