Interstitial lung disease and risk of mortality: 11-year nationwide population-based study

Choi, Won-Il; Park, S. H.; Dauti, Sonila; Park, B. J.; Lee, C. W.

doi:10.5588/ijtld.17.0167

Cited by 7 publications

(7 citation statements)

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“…On the other hand, it is possible that we could underestimated the incidence of ILD, because of inaccurate data especially in asymptomatic patients with ILD, Also, ILD outcomes should be affected by treatment, a variable that we could not include in our study. Nevertheless previous studies using database data in USA [42] and in Asia [41] reported similar results. Although SNHDD have some limitations, it has a great advantage that it is mandated by the National Public Health System, and it includes almost 100% of admission in Spain and it is periodically audited.…”

Section: Discussionsupporting

confidence: 68%

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Characteristics and outcomes of patients hospitalized with interstitial lung diseases in Spain, 2014 to 2015

Pedraza-Serrano¹,

Jiménez-García²,

López‐de‐Andrés³

et al. 2019

Medicine

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Section: Discussionsupporting

confidence: 68%

“…They also found that lung cancer and bacterial pneumonia influenced on IHM in patients with idiopathic pulmonary fibrosis. In a recent Korean study, based on ICD codes like ours, Choi et al [41] also observed that patients with ILD have a significantly higher risk of death than matched controls.…”

Section: Discussionmentioning

confidence: 60%

Characteristics and outcomes of patients hospitalized with interstitial lung diseases in Spain, 2014 to 2015

Pedraza-Serrano¹,

Jiménez-García²,

López‐de‐Andrés³

et al. 2019

Medicine

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“…The presence of fibrosing interstitial pneumonia in RA patients is associated with a lower survival rate than that of RA alone [34], and CTD-ILD has a poorer prognosis than idiopathic interstitial pneumonia [19]. ILD-only also revealed higher mortality than non-ILD control [35]. In contrast, several studies have shown opposite or neutral results in relation to survival [36–40].…”

Section: Discussionmentioning

confidence: 99%

Lung Cancer development and mortality in interstitial lung disease with and without connective tissue diseases: a five-year Nationwide population-based study

et al. 2019

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Background Connective tissue disease associated with interstitial lung disease (CTD-ILD) and interstitial lung disease (ILD) alone have same pathological and imaging backgrounds. However, the differences between lung cancer development and the mortality risk between these two conditions are unclear. Incidence of primary lung cancer and all-cause mortality were studied between interstitial lung disease patients with and without connective tissue disease. Methods Data were extracted from the Korean National Health Insurance Research Database in 2009. A total of 12,787 cases of ILD without idiopathic pulmonary fibrosis and 2491 cases of CTD-ILD were diagnosed in 2009. The cohort was followed up until June 30, 2014. Incident lung cancers and all-cause mortality were ascertained. Results The overall incidence of lung cancer was 165.7 and 161.8 per 10,000 person-years in the CTD-ILD and ILD-only, respectively (rate ratio, 1.08; 95% confidence interval, 0.89–1.30). CTD-ILD patients in the 40–49 and 50–59 years old age groups had lung cancer incidence rates of 92.5 and 139.2, which were 2.0 and 1.7 times higher than those in the ILD-only, respectively. All-cause mortality was significantly higher in the CTD-ILD group compared to ILD-only group in patients aged 50–79 years. All-cause mortality of women in the 50–59, 60–69 and 70–79 age groups was 2.0, 1.8, and 1.4 times higher in the CTD-ILD group than in the ILD-only group, respectively. Conclusions CTD-ILD patients aged < 60 years had a higher lung cancer incidence than ILD-only patients in the same age group. Furthermore, CTD-ILD patients aged 50–79 years had higher all-cause mortality than ILD-only patients in the same age group.

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“…Patients with ILD are often asymptomatic until the lesion progresses significantly. Interstitial pulmonary abnormality (ILA), which is considered to be an early lesion of interstitial lung disease, has a higher mortality rate than patients without ILA [ 3 ] as well as ILD [ 4 ]. Furthermore, in patients with ILD, a study using health insurance claim data found that lung cancer incidence is higher than chronic obstructive pulmonary disease (COPD) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for interstitial lung disease: a 9-year Nationwide population-based study

et al. 2018

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BackgroundUnderstanding the risk factors that are associated with the development of interstitial lung disease might have an important role in understanding the pathogenetic mechanism of interstitial lung disease as well as prevention. We aimed to determine independent risk factors of interstitial lung disease development.MethodsThis was a retrospective cohort study with nationwide population-based 9-year longitudinal data. We selected subjects who were aged > 40 years at cohort entry and with a self-reported history of cigarette smoking. Cases were selected based on International Classification of Diseases codes. A cohort of 312,519 subjects were followed until December 2013. We used Cox regression analysis to calculate the hazard ratios (HRs) for interstitial lung disease development.ResultsInterstitial lung disease developed in 1972 of the 312,519 subjects during the 9-year period. Smoking (HR: 1.2; 95% confidence interval [CI]: 1.1–1.4), hepatitis C (HR: 1.6; 95% CI: 1.1–2.3), history of tuberculosis (HR: 1.5; 95% CI: 1.1–1.9), history of pneumonia (HR: 1.6; 95% CI: 1.3–2.0), and chronic obstructive pulmonary disease (HR: 1.8; 95% CI: 1.6–2.1), men (HR: 1.9; 95% CI: 1.7–2.1) were significantly associated with the development of interstitial lung disease. The risk of interstitial lung disease development increases with age, and the risk was 6.9 times higher (95% CI: 5.9–8.0) in those aged over 70 than in their forties.ConclusionsSmoking, hepatitis C, history of tuberculosis, history of pneumonia, chronic obstructive pulmonary disease, male sex, and older age were significantly associated with interstitial lung disease development.

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Interstitial lung disease and risk of mortality: 11-year nationwide population-based study

Abstract: ILD patients had a significantly higher risk of death than matched controls, after adjustment for potential confounders and comorbidities.

Cited by 7 publications

References 0 publications

Characteristics and outcomes of patients hospitalized with interstitial lung diseases in Spain, 2014 to 2015

Characteristics and outcomes of patients hospitalized with interstitial lung diseases in Spain, 2014 to 2015

Lung Cancer development and mortality in interstitial lung disease with and without connective tissue diseases: a five-year Nationwide population-based study

Risk factors for interstitial lung disease: a 9-year Nationwide population-based study

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