Interstitial lung disease in infancy

Balasubramanian, Sundaram; Janakiraman, Lalitha; Ganesh, Ramaswamy; Deenadayalan, M.; Naidu, Radhika K.

doi:10.1007/s12098-007-0113-z

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…These findings indicated a high percentage of HCMV infection in patients with unresolved pneumonia. For anatomical classification of pneumonia with acute HCMV infection, the percentage of interstitial pneumonia and bronchiolitis cases with acute HCMV infection was high, similar to a previous report (Table 2) [23]. …”

Section: Resultssupporting

confidence: 88%

Urine real-time polymerase chain reaction detection for children virus pneumonia with acute human cytomegalovirus infection

et al. 2014

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BackgroundHuman cytomegalovirus (HCMV) is an important pathogen of viral pneumonia in children. The diagnosis of acute HCMV infection is complicated and difficult.MethodsClinical and laboratory data of 6063 hospitalized children with respiratory infection and 509 with respiratory virus infection alone were retrospectively analyzed. Urine and respiratory specimens of 186 hospitalized children with pneumonia were also prospectively collected. Real-time polymerase chain reaction (PCR) and a chemiluminescent assay were used to detect HCMV DNA copy number, the pp65 gene, and HCMV IgM.ResultsThe patients with respiratory virus infection alone and those with pulmonary HCMV infection (n = 422) were mostly children aged <6 months old (82.91%, 422/509). The accuracy of urine HCMV DNA (82.32%) was higher than that of HCMV IgM (67.78%), indicating that PCR of urine samples is suitable for determining pediatric acute pulmonary HCMV infection. There was no significant difference in detecting HCMV DNA or the pp65 gene between urinary and respiratory specimens (P > 0.05) in 186 pediatric pneumonia cases. The accuracy of the pp65 gene measured in urine for determining acute pulmonary HCMV infection was the highest (93.01%).ConclusionsOur study shows a novel method for investigating acute pulmonary HCMV infection in children by using real-time PCR and non-invasive samples. This study also highlights the superiority and potential use of the pp65 gene as an important target for the diagnosis of acute pulmonary HCMV infection.

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Section: Resultssupporting

confidence: 88%

Urine real-time polymerase chain reaction detection for children virus pneumonia with acute human cytomegalovirus infection

et al. 2014

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“…Thirty three studies reported morbidity, treatment and/or outcomes associated with chILD (Supplementary material, S2). Thirteen studies described chILD disorders as a group and 20 studies described specific chILD disorders.…”

Section: Resultsmentioning

confidence: 99%

“…Other studies from developed countries that reported mortality included patient groups with variable periods of follow‐up, extending to 17 or 18 years of age. Two studies from India (excluded from Table ), with patients aged less than two years, reported mortality rates of 33% and 75% . For studies conducted in developed countries with cohorts spanning childhood and adolescence, mortality ranged from 6% to 19% (median, 13%).…”

Section: Resultsmentioning

confidence: 99%

“…Descriptions of clinical features were generally limited to presenting symptoms and signs, most commonly dyspnoea, tachypnoea, hypoxemia, cyanosis, digital clubbing, and failure to thrive. 10,11,17,18,22 Severe respiratory deficit that limited physical activity was reported 20 and recurrent respiratory infections were a component of the morbidity profile of chILD (14.5% of cases 21 ). chILD also occurred as a co-morbidity associated with other diseases (53% of cases 12 , 29% of cases 21 ).…”

Section: Morbidity Treatment and Outcomes Associated With Childmentioning

confidence: 99%

“…2 For chILD disorders overall mortality ranged from 6% to 30% (Table 4). The study with the highest reported mortality 2 was comprised of a patient group from the USA and Canada with onset of diffuse lung disease at less patients aged less than two years, reported mortality rates of 33% 22 and 75%. 17 For studies conducted in developed countries with cohorts spanning childhood and adolescence, mortality ranged from 6% to 19% (median, 13%).…”

Section: Morbidity Treatment and Outcomes Associated With Childmentioning

confidence: 99%

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Childhood interstitial lung disease: A systematic review

et al. 2015

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Automated tissues characterization helps to diagnosis the various diseases including Interstitial lung diseases (ILD). The various features and the several classifiers are used in categorize the different layers depend on the pattern presented in the image. The different types of diseases may occur in the lungs and some of the diseases happen to leave the scars. These scars can be found in the High Resolution Computed Tomography (HRCT) and have different pattern. The different diseases cause the different pattern in the images and these is classified using the efficient classifier that helps to diagnosis the diseases. In this paper, review for the many researches regarding to the classification of the different pattern from the Computed Tomography (CT) images is presented. The evaluation of the efficiency of the methods in terms of classifier and database used for the research is made. The Deep Convolution Neural Network (CNN) provides the promising classifier efficiency compared to the other researches for different pattern. In general, there are five types of pattern is classified: Healthy, ground glass, honeycomb, Fibrosis, and emphysema.

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50 years of pediatric pulmonology: Progress and future

2013

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Development of Pediatric Pulmonology as a speciality in India is steadily improving over past few decades. Present profile of Indian pediatric chest services include: asthma, recurrent infections, bronchiectasis, etc. It is expected to change and the emerging pulmonary illnesses include: human immunodeficiency virus (HIV infection) associated pulmonary illnesses, cystic fibrosis, primary ciliary dyskinesia, bronchopulmonary dysplasia, interstitial lung diseases, gastroesophageal reflux diseases, neuromuscular illnesses, sleep disorders, disorders due to malformations and opportunistic pulmonary infections. Respiratory infections constitute major load in pediatric outpatient services and are the leading cause of mortality in under-five children. To reduce morbidity and mortality due to respiratory tract infections, Indian Academy of Pediatrics (IAP) has developed Respiratory Tract Infection Group Education Module (RTIGEMS). After initial increase in prevalence of asthma, it seems to have stabilized now but going by the numbers, it will remain a major health problem in India. Diagnosis of pulmonary tuberculosis was always a challenge to pediatricians and with emergence of drug resistant tuberculosis, it is even more challenging. Presently few centers are providing specialized Pediatric pulmonology services in India. There is a need to develop more centers to enhance services including (a) assessment of pulmonary physiology by performing pulmonary function testing in all age groups, (b) improving diagnostic and therapeutic role of bronchoscopy and bronchoalveolar lavage, (c) sweat testing, (d) molecular diagnostics for various respiratory illnesses, and (e) utilizing advance imaging and minimally invasive technologies for diagnosis and treatment of respiratory illnesses. At present there is no degree course in Pediatric Pulmonology in India. Initially middle level pediatricians wanting to pursue their career in pediatric pulmonology should undergo training in existing centers. Trained persons should develop a network to collect data and answer relevant research questions.

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Interstitial lung disease in infancy

Abstract: CMV Infection was the commonest cause of ILD in infancy in our study. However, the consequences on long term follow up in these infants need to be ascertained.

Cited by 5 publications

References 7 publications

Urine real-time polymerase chain reaction detection for children virus pneumonia with acute human cytomegalovirus infection

Urine real-time polymerase chain reaction detection for children virus pneumonia with acute human cytomegalovirus infection

Childhood interstitial lung disease: A systematic review

50 years of pediatric pulmonology: Progress and future

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