Interstitial Lung Disease in Polymyositis and Dermatomyositis: Clinical Features and Prognosis as Correlated with Histologie Findings

Tazelaar, Henry D.; Viggiano, Robert W.; Pickersgill, Judith; Colby, Thomas V.

doi:10.1164/ajrccm/141.3.727

Cited by 349 publications

(213 citation statements)

References 16 publications

Supporting

Mentioning

198

Contrasting

Unclassified

Order By: Relevance

“…Several studies on the histopathology of ILD-PM/DM have demonstrated various histological patterns, such as UIP, NSIP, BOOP and DAD, and emphasised their prognostic significance [13,[25][26][27]. However, limited data are available on the histopathology of ILD-ADM. LEE et al [7] recently reported three cases of acute ILD-ADM with a histological finding of DAD, which was associated with poor outcome; whilst COTTIN et al [13] described three patients with chronic ILD-ADM who showed NSIP with a good prognosis [13].…”

Section: Discussionmentioning

confidence: 99%

Interstitial lung diseases associated with amyopathic dermatomyositis

Suda¹,

Fujisawa²,

Enomoto³

et al. 2006

Eur Respir J

152

116

View full text Add to dashboard Cite

The aim of the present study was to clarify the clinical characteristics and prognosis of patients with interstitial lung disease (ILD) associated with amyopathic dermatomyositis (ILD-ADM).The study consisted of 14 consecutive patients with ILD-ADM. Patients were classified into two categories, acute/subacute and chronic forms, according to the clinical presentation of ILD. The clinical features, responsiveness to therapy, and prognosis between the two forms were compared.Nine ILD-ADM patients were categorised as the acute/subacute form, and five as the chronic form. Arterial oxygen tension was significantly lower in the acute/subacute ILD than chronic ILD patients. On high-resolution computed tomography, ground-glass opacities were frequently found in the two forms, but consolidation was more common in acute/subacute ILD than chronic ILD. Bronchoalveolar lavage analysis showed higher numbers of total cells and lymphocytes in acute/subacute ILD than chronic ILD. Histologically, the most common finding was nonspecific interstitial pneumonia in the two forms, while diffuse alveolar damage was only found in acute/ subacute ILD. Acute/subacute ILD was generally resistant to therapy, while chronic ILD responded well. Notably, the mortality of acute/subacute ILD was much higher than that of chronic ILD (67 versus 0%, respectively).In conclusion, interstitial lung disease associated with amyopathic dermatomyositis includes two different forms, the acute/subacute and chronic forms, with distinct prognoses.

show abstract

Section: Discussionmentioning

confidence: 99%

Interstitial lung diseases associated with amyopathic dermatomyositis

Suda¹,

Fujisawa²,

Enomoto³

et al. 2006

Eur Respir J

152

116

View full text Add to dashboard Cite

show abstract

“…Patients with BOOP generally have a more favorable prognosis compared to those with diffuse alveolar lesions or interstitial pneumonia. 25,26 In our patients, there was one patient with clinical findings consistent with BOOP who had a good outcome after corticosteroid therapy. The presence of pulmonary hypertension is reported in the literature and is associated to interstitial pulmonary disease.…”

Section: Discussionmentioning

confidence: 66%

Síndrome antissintetase anti-Jo-1

Shinjo¹,

Levy‐Neto²

2010

Rev. Bras. Reumatol.

View full text Add to dashboard Cite

Objective: Given a lack of population-based studies, we report an epidemiological-clinic study of anti-Jo-1 antisynthetase syndrome (ASS). Patients and Methods: To study a retrospective cohort of a single-center from 1980 to 2010. Clinical-laboratory and demographic data were obtained from medical files. All patients fulfilled the Bohan and Peter criteria (1975) and presented anti-Jo-1, articular, muscle and lung involvement. Eighteen patients with anti-Jo-1 ASS were analyzed. Results: The mean age at disease onset was 39.9 ± 15.7 years and average disease duration was 9.7 ± 7.0 years. All subjects were white, and 94.4% were female. Constitutional symptoms occurred in 50 % of cases. There was cutaneous and gastrointestinal tract involvement in 66.6% and 55.6% of cases, respectively. No cases manifested neurologic or cardiac involvement. Half of the patients showed incipient pneumopathy, ground-glass opacities and basal pulmonary fibrosis. There was one case of tuberculosis, three of herpes zoster and one of non-Hodgkin lymphoma. One death occurred due to sepsis shock (hospital bronchopneumonia). All patients received prednisone (1mg/kg/day) and 12 (66.7%) participants received methyl prednisolone pulse therapy (1g/day, 3 days). Various immunosuppressants were used as corticosteroid tapers, depending on tolerance, side effects and/or refractoriness. Although disease relapse (clinical and/or laboratory) occurred in 87.5% of cases, 12 out of 16 patients (75%) were in disease remission at study endpoint. Conclusion: In the present study, almost all patients were white females and the disease relapse rate was high.

show abstract

“…Three major groups can be identified: bronchiolitis obliterans with organizing pneumonia (BOOP), usual or nonspecific interstitial pneumonia, and diffuse alveolar damage. The histologic appearance of interstitial lung disease in patients with polymyozitis and dermatomyozitis is a prognostic factor (13). Diffuse alveolar damage and usual interstitial pneumonia are poor prognostic subtypes, with only a 33% 5-years survival rate (13).…”

Section: Discussionmentioning

confidence: 99%

“…The histologic appearance of interstitial lung disease in patients with polymyozitis and dermatomyozitis is a prognostic factor (13). Diffuse alveolar damage and usual interstitial pneumonia are poor prognostic subtypes, with only a 33% 5-years survival rate (13). However, BOOP and nonspecific interstitial pneumonia have better prognosis.…”

Section: Discussionmentioning

confidence: 99%

İnterstisyel Akciğer Hastalığını Taklit Eden Pulmoner Amiloidoz

...

2012

Tftr

View full text Add to dashboard Cite

Interstitial Lung Disease in Polymyositis and Dermatomyositis: Clinical Features and Prognosis as Correlated with Histologie Findings

Cited by 349 publications

References 16 publications

Interstitial lung diseases associated with amyopathic dermatomyositis

Interstitial lung diseases associated with amyopathic dermatomyositis

Síndrome antissintetase anti-Jo-1

İnterstisyel Akciğer Hastalığını Taklit Eden Pulmoner Amiloidoz

Contact Info

Product

Resources

About