Interstitial Magnetic Resonance Lymphography: Comparative Animal Study of Gadofluorine 8 and Gadolinium Diethylenetriamine-Pentaacetic Acid

Shimada, Morio; Yoshikawa, Kohki; Suganuma, Tsunetoku; Kayanuma, Hideki; Inoue, Yusuke; Ito, Kuniko; Senoo, Atsushi; Hayashi, Sanshin

doi:10.1097/00004728-200307000-00036

Cited by 17 publications

(21 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gadofluorine is a micellular contrast agent composed of a surfactant with a highly hydrophobic perfluoroalkyl tail and a hydrophilic Gd 3þ chelating headgroup and has been shown to be especially successful for MR lymphography (158)(159)(160) and improved detection of atherosclerotic plaques (81,161). Barkenhausen et al studied the aortic arch of hyperlipidemic rabbits with MRI before and after the administration of gadofluorine (81).…”

Section: Micellular Contrast Agentsmentioning

confidence: 99%

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

et al. 2006

View full text Add to dashboard Cite

In the field of MR imaging and especially in the emerging field of cellular and molecular MR imaging, flexible strategies to synthesize contrast agents that can be manipulated in terms of size and composition and that can be easily conjugated with targeting ligands are required. Furthermore, the relaxivity of the contrast agents, especially for molecular imaging applications, should be very high to deal with the low sensitivity of MRI. Lipid-based nanoparticles, such as liposomes or micelles, have been used extensively in recent decades as drug carrier vehicles. A relatively new and promising application of lipidic nanoparticles is their use as multimodal MR contrast agents. Lipids are amphiphilic molecules with both a hydrophobic and a hydrophilic part, which spontaneously assemble into aggregates in an aqueous environment. In these aggregates, the amphiphiles are arranged such that the hydrophobic parts cluster together and the hydrophilic parts face the water. In the low concentration regime, a wide variety of structures can be formed, ranging from spherical micelles to disks or liposomes. Furthermore, a monolayer of lipids can serve as a shell to enclose a hydrophobic core. Hydrophobic iron oxide particles, quantum dots or perfluorocarbon emulsions can be solubilized using this approach. MR-detectable and fluorescent amphiphilic molecules can easily be incorporated in lipidic nanoparticles. Furthermore, targeting ligands can be conjugated to lipidic particles by incorporating lipids with a functional moiety to allow a specific interaction with molecular markers and to achieve accumulation of the particles at disease sites. In this review, an overview of different lipidic nanoparticles for use in MRI is given, with the main emphasis on Gd-based contrast agents. The mechanisms of particle formation, conjugation strategies and applications in the field of contrast-enhanced, cellular and molecular MRI are discussed.

show abstract

Section: Micellular Contrast Agentsmentioning

confidence: 99%

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

et al. 2006

View full text Add to dashboard Cite

show abstract

“…For the interstitial MRL, the use of several T 1 agents have been reported. Extracellular agents such as gadopentate dimeglumine can be used for MRL, although they demonstrated nonspecific distribution and fast elimination . Micelle‐forming agents, such as gadofluorine 8 and gadofluorine P, are also used for MRL.…”

mentioning

confidence: 99%

PEG‐poly(L‐lysine)‐based polymeric micelle MRI contrast agent: Feasibility study of a Gd‐micelle contrast agent for MR lymphography

Akai

Shiraishi

Yokoyama

et al. 2017

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

“…Compared with T2‐negative contrast agents, T1‐positive contrast agents offer a higher SNR and a better anatomic resolution in MR lymphography. In addition, T1‐shortening contrast agents result in an enhancement of both the lymph nodes and the lymphatic vessels (5, 7, 9). However, sufficient and uniform visualization of nodal sizes is crucial for evaluating the detailed internal anatomy and function of lymph nodes, and especially for differentiating benign lymph nodes from malignant ones.…”

Section: Discussionmentioning

confidence: 99%

“…Although the exact mechanism behind the retention of contrast agents in the lymph nodes is unknown, the small molecular agents taken up by the lymph nodes were recognized in the extracellular space rather than in the macrophage of the lymph nodes (5). Therefore, washout in the periphery of the nodes and rapid contrast extravasation inherent to the small molecular agent are evident (16, 17).…”

Section: Discussionmentioning

confidence: 99%

“…Several researchers have described the use of T1‐shortening blood pool agents for systemic lymph node display, including gadofluoramide (4–6), P760 and P792 (7), MS‐325 (8), and macromolecular Gd chelates such as Gd‐based dendritic polymers (9–12), Gd‐liposomes (13, 14), and Gd‐based linear polymers (15). These contrast agents are retained in the lymph nodes for a long period of time, and thus MRI can depict tumor invasion in the lymph nodes.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Gd [DTPA‐bis (2‐aminoethoxy) ethane] polymeric contrast agent with gadodiamide injection for interstitial MR lymphography: Experimental study with rabbits

Zhou¹,

Guo²,

Yu³

et al. 2005

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose:To compare the differences between macromolecular and small molecular contrast agents in interstitial magnetic resonance (MR) lymphography. Materials and Methods:In two groups of rabbits (N ϭ 12 each), 0.5-mL volumes of 0.5 M and 0.1 M gadodiamide, respectively, were injected subcutaneously into the dorsal feet of both hind legs. After a 24-hour interval, 0.5 mL of Gd [DTPA-bis (2-aminoethoxy) ethane] polymeric contrast agent (Gd-poly-DTPA-EOEA) injection (0.1 M) was injected into the same sites in each rabbit. T1-weighted three-dimensional gradient-echo and maximum intensity projection (MIP) images were obtained before and after the administration of each agent. The nodal maximum short-axis diameter (MSAD) and signal-to-noise ratio (SNR) at each time point were measured. Postmortem measurements of nodal MSADs were also performed. The nodal MSAD measurements obtained by MR lymphography were compared with the postmortem measurements. As an additional control experiment, six rabbits received a subcutaneous injection of 0.5 mL of 0.1 M gadodiamide at the same sites as those described above. This procedure was repeated after a 24-hour interval to determine whether the first injected gadodiamide had any effect on the performance of the subsequently injected agent, by comparing the differences in nodal MSADs obtained by MR lymphography after each injection.Results: Gd-poly-DTPA-EOEA showed a significantly longer enhancement plateau compared to gadodiamide. In comparison with postmortem measurements, nodal measurements by MR lymphography with Gd-poly-DTPA-EOEA at the peak-enhancement phase revealed no significantly different MSADs (P Ͼ 0.05), whereas nodal measurements by MR lymphography with gadodiamide showed significantly smaller MSADs (P Ͻ 0.05). A comparison of the nodal MSADs measured in two gadodiamideenhanced MR examinations after the 24-hour interval showed no significant difference (P Ͼ 0.05). Conclusion:Interstitial MR lymphography with polymeric Gd-poly-DTPA-EOEA enhancer enables more sufficient and reliable visualization of lymph nodes compared to small molecular gadodiamide.

show abstract

Interstitial Magnetic Resonance Lymphography: Comparative Animal Study of Gadofluorine 8 and Gadolinium Diethylenetriamine-Pentaacetic Acid

Abstract: These studies indicated that G8 was more suitable than Gd-DTPA as a contrast agent for interstitial MRL up to 90 minutes.

Cited by 17 publications

References 10 publications

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

PEG‐poly(L‐lysine)‐based polymeric micelle MRI contrast agent: Feasibility study of a Gd‐micelle contrast agent for MR lymphography

Comparison of Gd [DTPA‐bis (2‐aminoethoxy) ethane] polymeric contrast agent with gadodiamide injection for interstitial MR lymphography: Experimental study with rabbits

Contact Info

Product

Resources

About