Interstitial photodynamic therapy: diagnostic measurements and treatment in experimental malignant rat tumors

Stenberg, Maria; Thompson, Marcelo Soto; Johansson, Thomas; Pålsson, Sara; Klinteberg, Claes af; Andersson‐Engels, Stefan; Stenram, Unne; Svanberg, Sune; Svanberg, Katarina

doi:10.1117/12.409325

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…1. The development of this concept has been pursued in incremental steps 14,15 with promising experimental 16 and clinical results. 17 In the previous system 14 it was possible to measure the therapeutic light flux in the lesion but the system construction did not allow the measurements of other parameters.…”

Section: Introductionmentioning

confidence: 99%

Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

Thompson¹,

Johansson²,

Johansson³

et al. 2005

Appl. Opt.

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A system for interstitial photodynamic therapy with ␦-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photobleaching, and a relatively constant global tissue oxygen saturation level during the treatment.

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Section: Introductionmentioning

confidence: 99%

Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

Thompson¹,

Johansson²,

Johansson³

et al. 2005

Appl. Opt.

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“…A successful PDT procedure requires providing an adequate amount of light from the source to the target and ensuring homogeneous distribution of light (15). A light delivery system must be used in conjunction with advanced dosimetric software for its efficient utilization, in which measured diagnostic signals are fed into a dose distribution calculation program (40)(41)(42)(43). In the illumination, the accepted approach is to deliver a threshold dose, which is a minimum dose adequate to cause direct cell death, delivered to a target tissue volume (15).…”

Section: Jarvi Et Al Further Reported Comparative Poltsmentioning

confidence: 99%

Photodynamic Therapy : An Overview and Insights into a Prospective Mainstream Anticancer Therapy

VİTHANAGE

C.D.

DE.

et al. 2022

Journal of the Turkish Chemical Society Section A: Chemistry

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Photodynamic therapy (PDT) procedure has minimum invasiveness in contrast to conventional anticancer surgical procedures. Although clinically approved a few decades ago, it is not commonly used due to its poor efficacy, mainly due to poor light penetration into deeper tissues. PDT uses a photosensitizer (PS), which is photoactivated on illumination by light of appropriate wavelength and oxygen in the tissue, leading to a series of photochemical reactions producing reactive oxygen species (ROS) triggering various mechanisms resulting in lethal effects on tumor cells. This review looks into the fundamental aspects of PDT, such as photochemistry, photobiological effects, and the current clinical applications in the light of improving PDT to become a mainstream therapeutic procedure against a broad spectrum of cancers and malignant lesions. The side effects of PDT, both early and late-onset, are elaborated on in detail to highlight the available options to minimize side effects without compromising therapeutic efficacy. This paper summarizes the benefits, drawbacks, and limitations of photodynamic therapy along with the recent attempts to achieve improved therapeutic efficacy via monitoring various cellular and molecular processes through fluorescent imagery aided by suitable biomarkers, prospective nanotechnology-based targeted delivery methods, the use of scintillating nanoparticles to deliver light to remote locations and also combining PDT with conventional anticancer therapies have opened up new dimensions for PDT in treating cancers. This review inquires and critically analyses prospective avenues in which a breakthrough would finally enable PDT to be integrated into mainstream anticancer therapy.

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“…By monitoring the amount of light passing between the fiber tips it is possible to model the light dose distribution throughout the tumor. The system was evaluated in the treatment of experimental tumors in rats, 45,46 and was later used in early treatment of solid hu-man tumors. [47][48][49] Photographs from a treatment session are included in Fig.…”

Section: Interstitial Pdt For Prostate Cancermentioning

confidence: 99%

Photodynamic therapy: superficial and interstitial illumination

Bendsöe

2010

J. Biomed. Opt

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Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different challenges facing the two modalities of PDT-superficial and interstitial. They thus serve as good examples to illustrate the entire field of PDT in oncology. PDT is discussed based on the Lund University group's over 20 yr of experience in the field. In particular, the interplay between optical diagnostics and dosimetry and the delivery of the therapeutic light dose are highlighted. An interactive multiple-fiber interstitial procedure to deliver the required therapeutic dose based on the assessment of light fluence rate and sensitizer concentration and oxygen level throughout the tumor is presented.

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Interstitial photodynamic therapy: diagnostic measurements and treatment in experimental malignant rat tumors

Cited by 6 publications

References 9 publications

Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

Photodynamic Therapy : An Overview and Insights into a Prospective Mainstream Anticancer Therapy

Photodynamic therapy: superficial and interstitial illumination

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