Interstitial photodynamic therapy with rotating and reciprocating optical fibers

Tanaka, Hideo; Hashimoto, Kenji; Yamada, Isao; Masumoto, Kazuma; Ohsawa, Takayuki; Murai, Mutsuhiko; Hirano, Tôru

doi:10.1002/1097-0142(20010501)91:9<1791::aid-cncr1198>3.0.co;2-9

Cited by 25 publications

(4 citation statements)

References 28 publications

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“…By stepwise retracting the optical fibres, the entire tumour volume can be treated. Until now this technique seems to be mainly applicable for palliative indications as an exact calculation of the light distribution is still rather difficult even though good clinical results have been reported [21].…”

Section: Discussionmentioning

confidence: 99%

Experimental evaluation of possible side effects of intra‐operative photodynamic therapy on rabbit blood vessels and nerves

et al. 2003

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Our results have shown that mTHPC mediated intra-operative PDT used with a maximal treatment protocol (very high doses and very short drug-light intervals) has significant histological impact onto all tissue structures, but did not show any clinical symptoms in rabbits. mTHPC mediated intra-operative PDT seems to be a promising and a safe treatment option which could complement existing treatment modalities in order to improve total survival rate of tumour patients.

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Section: Discussionmentioning

confidence: 99%

Experimental evaluation of possible side effects of intra‐operative photodynamic therapy on rabbit blood vessels and nerves

et al. 2003

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“…No recurrence of the verrucous carcinoma lesion was found after a follow-up period of six months. They suggested that new topical ALA-PDT protocol composed of multiple threeminute fractionated irradiations with a light emitting diode (LED) red light at 635 +5 nm for a total of 1000 s after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia [21,22].…”

Section: Verrucouscarcinomamentioning

confidence: 99%

Photodynamic therapy: A new modality treatment in pre-cancer and cancer patients

Velpula¹,

Lingam²

2014

Int J Case Rep Images

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Introduction: Photodynamic therapy (PDt) is a new modality of therapy being used for the diagnosis and treatment in pre-cancer and cancer patients and various skin diseases. Photodynamic therapy is a powerful lightinitiated photochemical reaction, involving the use of a photoactive dye (photosensitizer) activated by light of a specific wavelength in the presence of oxygen. this leads to the formation of oxygen free radicals which are toxic, which can damage proteins, lipids, nucleic acids and other components. Application of photodynamic therapy in dentistry is growing rapidly for the use of oral pre-cancers and cancer lesions, bacterial and fungal infections. Photodynamic antimicrobial chemotherapy (PAct) has been efficacious in the management of periodontal infections, peri-implantitis, endodontic infections and oral bio-films formation. the absence of genotoxic and mutagenic effects and no risk of developing resistance to its antimicrobial action made its use important.

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“…This is achieved by having the fiber tip polished at 45 degrees or attached with a micro prism to direct the optical beam to the side. To cover a macroscopically large tissue area as typically required in photodynamic therapy (PDT), such a side-emitting fiber is inserted into the distal end of target tissue and slowly pulled out while it is rotated [2,3]. However, this scanning technique increases the procedure time and requires skilled operator expertise.…”

Section: Introductionmentioning

confidence: 99%

Polyethersulfone optical fibers with thermally induced microbubbles for custom side-scattering profiles

Shabahang¹,

Forward²,

Yun³

2019

Opt. Express

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Polyethersulfone (PES) optical fibers are drawn and thermally processed in order to generate variable side-illumination profiles. The thermal treatment allows microbubbles to be formed in an outer layer of the PES fiber, providing light scattering with controllable amplitudes (0.25-2.5 cm −1 ). Several fibers with different scattering profiles, such as uniform axial irradiation and multiple irradiation spots, are demonstrated. A small microbubbleinduced scattering spot on the surface may be used for side-coupling of ambient light into the fiber. These mechanically flexible all-PES fibers with custom-designable scattering profiles may be useful for spatially tuned delivery of light for various applications, including phototherapy.

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Interstitial photodynamic therapy with rotating and reciprocating optical fibers

Cited by 25 publications

References 28 publications

Experimental evaluation of possible side effects of intra‐operative photodynamic therapy on rabbit blood vessels and nerves

Experimental evaluation of possible side effects of intra‐operative photodynamic therapy on rabbit blood vessels and nerves

Photodynamic therapy: A new modality treatment in pre-cancer and cancer patients

Polyethersulfone optical fibers with thermally induced microbubbles for custom side-scattering profiles

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