Interstudy reproducibility of three‐dimensional volume‐selective fast spin echo magnetic resonance for quantifying carotid artery wall volume

Varghese, Anitha; Crowe, Lindsey A.; Mohiaddin, Raad H.; Gatehouse, Peter; Yang, Guang; Nott, David; McCall, James M.; Firmin, David N.; Pennell, Dudley J.

doi:10.1002/jmri.20249

Cited by 29 publications

(23 citation statements)

References 20 publications

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“…This is reflected by the improved detection of complex atherosclerotic plaque at 3T, as validated by histology (36), and the increased SNR, CNR, and improved image quality of the carotid images at 3T (21) as compared to 1.5T. In the current study we evaluated a GRE sequence with 0.46 mm ϫ 0.46 mm ϫ 2 mm spatial resolution, which is comparable to that employed in recent studies at 1.5T (28,29).…”

Section: Discussionmentioning

confidence: 96%

“…FSE sequences with multiple contrast weightings are commonly used to meet these requirements, and some reports have shown reliable results with GRE sequences (27). Recent studies have shown the reproducibility of a 3D volume-selective FSE sequence in both patients with known atherosclerotic disease (28) and asymptomatic patients (29). While most prior work on carotid vessel wall imaging was performed at 1.5T using FSE techniques, the present study was conducted at 3T using a spoiled GRE (SPGRE) imaging sequence.…”

Section: Discussionmentioning

confidence: 97%

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Assessment of the carotid artery by MRI at 3T: A study on reproducibility

Dehnavi

Doornbos

Tamsma

et al. 2007

Magnetic Resonance Imaging

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Purpose:To examine the reproducibility of carotid artery dimension measurements using 3T MRI. Materials and Methods:Ten healthy volunteers underwent three scans on two occasions for assessment of total vessel wall area (TVWA), total luminal area (TLA), and minimum (MinT) and maximum (MaxT) vessel wall thickness. A double inversion-recovery (IR) fast gradient-echo (FGRE) sequence was used on a commercial 3T system. During the first visit the subjects were scanned twice. The third scan was performed at least four days later. One observer traced all scans, and a second observer retraced the first scan series. Conclusion:With the use of a commercial 3T MR system, TVWA, TLA, and wall thickness measurements of the carotid artery can be assessed with good reproducibility.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Assessment of the carotid artery by MRI at 3T: A study on reproducibility

Dehnavi

Doornbos

Tamsma

et al. 2007

Magnetic Resonance Imaging

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show abstract

“…Most work has been performed in the carotid artery and aorta, because of its closeness to the surface and larger size, respectively. Studies with carotid MRI demonstrated an interstudy reproducibility of 4.4% 85 . A number of serial studies in humans have assessed CMR in the longitudinal measurement of aortic and carotid atheroma [86][87][88][89][90] .…”

Section: Cardiovascular Magnetic Resonancementioning

confidence: 94%

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Schoenhagen¹,

Tuzcu²

2008

Arq. Bras. Cardiol.

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SummaryCAD remains a major global cause of morbidity and mortality. Comprehensive drug development programs of novel pharmacological treatment strategies frequently utilize traditional mortality/morbidity endpoints studies and additional surrogate endpoints trials. This parallel approach allows an assessment of efficacy several years in advance of the availability of data from clinical endpoint trials. Several atherosclerosis imaging markers have been introduced into these drug-development strategies, including angiography, carotid ultrasound, IVUS, MRI, and CT. This review will discuss the current status of atherosclerosis imaging as an endpoint in progression/regression trials, with an emphasis on evidence-based data. In addition to a discussion of the results of individual imaging modalities, the emerging data comparing different modalities and approaches are presented.

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“…An additional limitation is that only one viewer was used to analyze all datasets so that no data were available on interobserver variability with this technique. However, previous work has shown the interstudy variability to be of the order of 4.5% (12,13).…”

Section: Discussionmentioning

confidence: 90%

“…In general, the benefits of reduced scan time and improved resolution need to be weighed against the consequent reduction in SNR, and the final protocol will depend on the desired clinical application. 3D carotid wall imaging also has good reproducibility (12), although this has not yet been reproduced in patients with carotid atherosclerosis (28). Finally, 3D data have the advantage that any slice orientation can be retrospectively displayed by selecting appropriate 3D voxels from it, and this can be most helpful if, for example, the carotid arteries are not parallel.…”

Section: Discussionmentioning

confidence: 99%

Comparison of 2D and multislab 3D magnetic resonance techniques for measuring carotid wall volumes

Keenan

Grasso

Locca

et al. 2008

Magnetic Resonance Imaging

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Purpose: To compare a multislab three-dimensional volume-selective fast spin-echo (FSE) magnetic resonance (MR) sequence with a routine two-dimensional FSE sequence for quantification of carotid wall volume. Materials and Methods:One hundred normal subjects (50 men, mean age 44.6 years) underwent carotid vessel wall MR using 2D and 3D techniques. Carotid artery total vessel volume, lumen volume, wall volume, and wall/outer wall (W/OW) ratio were measured over 20 contiguous slices. Two-(2D) and three-dimensional (3D) results were compared. Results:The mean difference between 2D and 3D datasets (as a percentage of the mean absolute value) was 1.7% for vessel volume, 4.9% for lumen volume, 4.7% for wall volume, and 5.8% for W/OW ratio. There was good correlation between 2D and 3D models for total vessel volume (R 2 ϭ 0.93, P Ͻ 0.001), lumen area (R 2 ϭ 0.92, P Ͻ 0.001), and wall volume (R 2 ϭ 0.77, P Ͻ 0.001). The correlation for the W/OW ratio was weaker (R 2 ϭ 0.30; P Ͻ 0.001). The signalto-noise ratio (SNR) for the 3D technique was 2.1-fold greater than for the 2D technique (P Ͻ 0.001). When using the 3D sequence, scan time was reduced by 63%. Conclusion:Multislab volume selective 3D FSE carotid arterial wall imaging performs similarly to a conventional 2D technique, but with over twice the SNR and substantially reduced scan time. CARDIOVASCULAR MAGNETIC RESONANCE (MR) is a good technique for assessing atherosclerosis in the carotid artery, with much development over the last 15 years in plaque characterization and assessment of the structure and function of the arterial wall (1-6). Quantitative carotid wall imaging typically requires a stack of two-dimensional (2D) images, which can be contoured and analyzed. Acquisition protocols vary, but scan times of the order of 1 hour are common so as to cover an adequate length of the carotid artery with contiguous slices. Long scan times limit the applicability of the technique. As scan times increase, patient comfort and acceptability decrease, and patient movement increases, leading to image degradation from movement artifact (7). Long scan times also limit the feasibility of using carotid MR in large clinical studies. To reduce the scan time, a localized three-dimensional (3D) fast spinecho (FSE) sequence for carotid artery imaging has been developed and validated (8 -13).In conventional 3D imaging, rather than a single slice, a slab of tissue is excited by the radiofrequency (RF) pulse. Spatial encoding is performed in 3D by using additional phase encoding in the direction perpendicular to the selected slab, along with an additional dimension of Fourier transformation for image reconstruction (14). The 3D images have an inherently higher signal-to-noise ratio (SNR), so fewer cardiac cycles are needed than with 2D to produce similar image quality at the same voxel size (8,15). In theory, the SNR advantage of 3D over 2D is ͌N, where N is the number of 3D phase-encode steps in the partition direction. Using perpendicular 90°and 180°selection gradients, the 3D slab can ...

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Interstudy reproducibility of three‐dimensional volume‐selective fast spin echo magnetic resonance for quantifying carotid artery wall volume

Cited by 29 publications

References 20 publications

Assessment of the carotid artery by MRI at 3T: A study on reproducibility

Assessment of the carotid artery by MRI at 3T: A study on reproducibility

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Comparison of 2D and multislab 3D magnetic resonance techniques for measuring carotid wall volumes

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