Intersubject Synchronisation Analysis of Brain Activity Associated with the Instant Effects of Acupuncture: An Fmri Study

Jin, Lu; Sun, Jinbo; Xu, Zhibo; Yang, Xuejuan; Liu, Peng; Qin, Wei

doi:10.1136/acupmed-2016-011327

Cited by 10 publications

(11 citation statements)

References 39 publications

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“…To our knowledge, this is the first study to explore the differences between instant and sustained effect of head acupoint in depression. Acupuncture treatment produces both instant and sustained effects, [16][17][18] our study indicated that EA at GV20 could first instantly activated bilateral postcentral gyri, right calcarine gyrus, right cuneus. The bilateral postcentral gyri was the hub in the somatosensory network, which identified by early functional connectivity studies.…”

Section: Discussionmentioning

confidence: 61%

The Instant and Sustained Effect of Electroacupuncture in Postgraduate Students with Depression: An fMRI Study

Wei¹,

Chen²,

Guo³

et al. 2021

NDT

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Objection: This study was a primary study to evaluate the instant and sustained effect of electroacupuncture (EA) at GV20 (Baihui) in postgraduate students with mild depression by using a special flexible head coil. Methods: A total of 20 postgraduate students with mild depression underwent EA stimulation at GV20 and 3 phases of resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Phase I: Preparation (before needle insertion); Phase II: during EA; Phase III: 15 minutes after needle removal. The Rs-fMRI data were processed using DPABI and SPSS 25. Results: 1) ReHo values showed significantly differences in the right posterior cingulate cortex, right calcarine gyrus, right angular gyrus, right precuneus, right cuneus, and bilateral postcentral gyri among Phase I, Phase II and Phase III; 2) Relative to the Phase I, increased brain activity in the Phase II was observed in the bilateral postcentral gyri, right calcarine gyrus, right cuneus. Compared with the Phase II, decreased brain activity in the Phase III was observed in the right precuneus, right posterior cingulate cortex, right angular gyrus. Relative to the Phase I, Significantly increased brain activity in the Phase III was observed in the right calcarine gyrus, right cuneus, and bilateral postcentral gyri. While decreased ReHo values were found in the right posterior cingulate cortex, right angular gyrus, right precuneus; and 3) Correlation analysis showed that the ReHo values of multiple brain regions in Phase I and Phase III were significantly correlated with the VAS and HRSD-17 scores. Conclusion: This study focuses on the instant and sustained effect in postgraduate students with depression. Our study showed that instant effect produced by EA stimulation at GV20 firstly induced changes in somatosensory and visual area, and then, sustained effect (Phase III) have a higher intensity and more extensive than instant effects. Meanwhile, we provide a visualization way to study the instant effects of head acupoints by using a flexible head coil.

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Section: Discussionmentioning

confidence: 61%

The Instant and Sustained Effect of Electroacupuncture in Postgraduate Students with Depression: An fMRI Study

Wei¹,

Chen²,

Guo³

et al. 2021

NDT

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“…Comparisons between ReHo and ALFF values (effective acupuncture versus. sham acupuncture sessions) were performed using the paired sample t test (Jin et al., 2018; Qiu et al., 2012; Zhu et al., 2015). Significance was indicated by p = .001 at the voxel level (uncorrected) and p < .05 at the cluster level (family‐wise error correction).…”

Section: Methodsmentioning

confidence: 99%

“…We attempted to explore the involved cerebral areas by comparing the changes of ReHo and ALFF values between posteffective acupuncture and postsham acupuncture. For the aim of this study to explore the cerebral changes induced by acupuncture on SP3, we selected unilateral acupuncture on the right side (relevant to the dominant hemisphere) according to the experimental design of the previous studies (Jin et al., 2018; Qiu et al., 2012). We believed that the findings in the present study will be useful to further understand the effects of acupuncture on the SP3 point on different cerebral areas.…”

Section: Introductionmentioning

confidence: 99%

Cerebral areas affected by unilateral acupuncture on SP3 in healthy volunteers: An explorative resting‐state fMRI study

Wang

Yang

et al. 2021

Brain and Behavior

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Objective The study aimed to explore the cerebral areas with changes in regional homogeneity (ReHo) and amplitude of low‐frequency fluctuation (ALFF) values induced by effective acupuncture on the Taibai (SP3) point. Methods In the study, 15 healthy right‐handed volunteers (seven males and eight females, 20–35 years old) were enrolled. The average ages of the subjects were 28.0 ± 4.24 years for males and 27.4 ± 3.65 years for females. A 3.0T magnetic resonance imaging (MRI) system was used to perform resting‐state functional MRI scan after sham and effective acupuncture on the SP3 point. The differences in cerebral ReHo and ALFF values between posteffective acupuncture and postsham acupuncture were compared using the SPM 12 software. Results ReHo values of bilateral BA18, cuneus, and BA17, along with BA41, BA22, postcentral gyrus, and BA7 on the right side, were decreased by effective SP3 acupuncture. The ALFF values of bilateral BA 30 and left parahippocampal area were increased, whereas the values of bilateral BA18, BA19, cuneus, posterior cingulate gyrus, and BA7, along with the right superior occipital lobule, postcentral gyrus, and left precuneus, were decreased. Conclusions The most dominant cerebral areas affected by SP3 acupuncture were bilateral visual‐related cortices (lingual gyrus, cuneus, and calcarine), along with the unilateral postcentral gyrus and superior parietal lobule. These findings may be potential explanations for the available clinical reports concerning the efficacy of SP3 acupuncture. Further clinical and experimental studies on SP3 acupuncture are required.

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“…One of the focuses of this research is tbfMRI employed to explore the changes in brain activation during the acupuncture stimulation or a period after stimulation [28][29][30][31][32][33] . These studies last for a shorter time taking healthy volunteers or patients as subjects.…”

Section: De Nitions and Conceptsmentioning

confidence: 99%

“…A small number, one or two, of acupoints are selected in these studies, and a one-time acupuncture administration is given in one experimental program. These studies usually aim to discuss the instant effects [31] and sustained effects [32] of acupuncture. According to the theory of TCM, acupuncture may induce long-lasting post-administration effects [33] .…”

Section: De Nitions and Conceptsmentioning

confidence: 99%

Acupuncture Mechanism Studies Employing Task-based fMRI: A Scoping Review Protocol

Yan¹,

Sheng²,

Wang³

et al. 2020

Preprint

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Background: Acupuncture is a widely used alternative and complementary therapy. Functional Magnetic Resonance Imaging (fMRI) is an important technique to explore the underlying mechanism of acupuncture, and the task-based fMRI can reflect the instant effects or sustained effects of acupuncture in the brain. This scoping review aims to summarize the characteristics of acupuncture mechanism studies employing Task-based fMRI and conclude a reference for future studies.Methods/design: This review will follow the Guidance for Conducting Systematic Scoping Reviews. Eligible articles will be collected from 6 databases (PubMed, Embase, Cochrane, CNKI, WanFang and VIP) with the related keywords such as “Acupuncture” and “fMRI” and those articles should be published from the establishment of the database to June 30th, 2020. Each research step will involve at least two reviewers. The PRISMA-ScR (Preferred Reporting Items for Systemic Reviews and Meta-Analysis Extension for Scoping Reviews) will be used to organize the review.Discussion: This review aims to clarify the extent of acupuncture mechanism studies employing task-based fMRI. It is supposed to make a critical evaluation or to propose quality requirements for future studies by summarizing the objectives and designs of eligible studies. What’s more, directional suggestions will be provided for further studies.Scoping review registration: Open Science Framework https://osf.io/zjrdc/.

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Intersubject Synchronisation Analysis of Brain Activity Associated with the Instant Effects of Acupuncture: An Fmri Study

Abstract: The ISS analysis considered the sustained effect of acupuncture and uncovered additional information not shown by GLM analysis. We suggest that ISS may be a suitable approach to investigate the brain responses associated with the instant effects of acupuncture.

Cited by 10 publications

References 39 publications

The Instant and Sustained Effect of Electroacupuncture in Postgraduate Students with Depression: An fMRI Study

The Instant and Sustained Effect of Electroacupuncture in Postgraduate Students with Depression: An fMRI Study

Cerebral areas affected by unilateral acupuncture on SP3 in healthy volunteers: An explorative resting‐state fMRI study

Acupuncture Mechanism Studies Employing Task-based fMRI: A Scoping Review Protocol

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