Intertriginous granular parakeratosis

Focal Acral Hyperkeratosis with Intracorneal Retention of Keratohyalin Granules

“…[7] To our knowledge retention of keratohyalin granules had never been describe-ed in FAH and could merely represent a reaction pattern to external irritation (shaving) as suggested by others for GP. [8] Alternatively, retention of keratohyalin granules could relate to a primary defect of cornification in patients with FAH and if reproducible could potentially serve as a histopathological discriminator from AKE.…”

Axillary Granular Parakeratosis

“…Northcutt et al 1 speculated that a contact allergen, likely found in deodorants or antiperspirants, is responsible for the eruption. Other authors 3,7 have questioned this theory, citing unilateral distribution and occurrence of the eruption outside the axillae as evidence to the contrary. Mehregan et al 3 proposed that mechanical irritation in the setting of the humid environment of the intertriginous areas might lead to a protective proliferation of epidermis.…”

“…[1][2][3][4][5][6][7][8][9] Reported therapeutic options have included discontinuation of deodorant or changing deodorants. Topical modalities have included steroids, antifungals, antibiotics, vitamin D derivatives, and retinoids.…”

“…Extra-axillary sites included the groin, 2,3 inter-and inframammary areas, 2,4 perianal area, 2 and the abdomen. 2 For this reason, the alternative terms granular parakeratosis 2,4 and intertriginous granular parakeratosis 3 have been proposed.…”

Granular Parakeratosis in a Child

“…Subsequently, other authors demonstrated that GP could involve other cutaneous folds, so the term GP now seems more appropriate to define this peculiar entity which typically affects adults, mainly women beyond their 5th decade [2][3][4]. We describe for the first time a case of axillary GP in a young girl.…”