Interval timing and midfrontal delta oscillations are impaired in Parkinson’s disease patients with freezing of gait

Bosch, Taylor J.; Barsainya, Richa; Ridder, Andrew; Santosh, K. C.; Singh, Anneliese A.

doi:10.1007/s00415-021-10843-9

Cited by 9 publications

(14 citation statements)

References 58 publications

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“…Similar to our previous reports, altered network measures existed in the lower frequency band for PD versus healthy subjects, and PDFOG+ versus PDFOG−. 6,7 Furthermore, lower frequency midfrontal clustering coefficient correlated with patient-reported severity of FOG.…”

Section: Discussionsupporting

confidence: 87%

“…This finding coincides with our previous work demonstrating deficits in midfrontal low frequency oscillations in individuals with FOG. 6,7…”

Section: Resultsmentioning

confidence: 99%

“…Based on our previous reports showing altered midfrontal theta activity during motor and cognitive tasks in PD and PDFOG+, we focused our analysis on the theta frequency band and selected the midfrontal location as a provincial hub. 6,7,30,33 Theta activity in the midfrontal cortical region has been observed during cognitive tasks and motor tasks that require attention or cognitive load. 42 Furthermore, we previously observed alterations in midfrontal theta activity during cognitive tasks and dual tasks (i.e., motor tasks with cognitive challenge) in PD and PDFOG+ groups.…”

Section: Discussionmentioning

confidence: 99%

“…6,26 Disease and FOG severity in PD participants were assessed via the motor part of the Unified Parkinson’s Disease Rating Scale 27 and FOG questionnaire, respectively. 28 Similar to our previous studies, 6,7,26 PDFOG+ were grouped if they met both of the following criteria: (i) participants confirmed they had problems starting, stopping, and turning during walking; (ii) their FOGQ (number 3) score was >0, suggestive of at least 1 FOG episode in the past month. Characteristics of all the participants have been described in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…32 Based on our previous work, we focused our analysis on the theta (4-7 Hz) frequency band and selected the midfrontal Cz channel for nodal analysis. 6,7,30,33…”

Section: Methodsmentioning

confidence: 99%

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Functional Connectivity in Patients With Parkinson’s Disease and Freezing of Gait Using Resting-State EEG and Graph Theory

Bosch

Espinoza

Mancini

et al. 2022

Neurorehabil Neural Repair

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Background Although many studies have shown abnormalities in brain structure and function in people with Parkinson’s disease (PD), we still have a poor understanding of how brain structure and function relates to freezing of gait (FOG). Graph theory analysis of electroencephalography (EEG) can explore the relationship between brain network structure and gait function in PD. Methods Scalp EEG signals of 83 PD (42 PDFOG+ and 41 PDFOG−) and 42 healthy controls were recorded in an eyes-opened resting-state. The phase lag index was calculated for each electrode pair in different frequency bands, but we focused our analysis on the theta-band and performed global analyses along with nodal analyses over a midfrontal channel. The resulting connectivity matrices were converted to weighted graphs, whose structure was characterized using strength and clustering coefficient measurements, our main outcomes. Results We observed increased global strength and increased global clustering coefficient in people with PD compared to healthy controls in the theta-band, though no differences were observed in midfrontal nodal strength and midfrontal clustering coefficient. Furthermore, no differences in global nor midfrontal nodal strength nor global clustering coefficients were observed between PDFOG+ and PDFOG− in the theta-band. However, PDFOG+ exhibited a significantly diminished midfrontal nodal clustering coefficient in the theta-band compared to PDFOG−. Furthermore, FOG scores were negatively correlated with midfrontal nodal clustering coefficient in the theta-band. Conclusion The present findings support the involvement of midfrontal theta oscillations in FOG symptoms in PD and the sensitivity of graph metrics to characterize functional networks in PDFOG+.

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Section: Discussionsupporting

confidence: 87%

“…This finding coincides with our previous work demonstrating deficits in midfrontal low frequency oscillations in individuals with FOG. 6,7…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…32 Based on our previous work, we focused our analysis on the theta (4-7 Hz) frequency band and selected the midfrontal Cz channel for nodal analysis. 6,7,30,33…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Functional Connectivity in Patients With Parkinson’s Disease and Freezing of Gait Using Resting-State EEG and Graph Theory

Bosch

Espinoza

Mancini

et al. 2022

Neurorehabil Neural Repair

Self Cite

View full text Add to dashboard Cite

show abstract

Leveraging Handwriting Impairment as a Biomarker for Early Parkinson’s Disease Diagnosis

Chacko,

Rizk,

Santosh

2024

Communications in Computer and Information Science

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Cerebellar oscillatory dysfunction during lower-limb movement in Parkinson’s disease with freezing of gait

2023

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Interval timing and midfrontal delta oscillations are impaired in Parkinson’s disease patients with freezing of gait

Abstract: doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.

Cited by 9 publications

References 58 publications

Functional Connectivity in Patients With Parkinson’s Disease and Freezing of Gait Using Resting-State EEG and Graph Theory

Functional Connectivity in Patients With Parkinson’s Disease and Freezing of Gait Using Resting-State EEG and Graph Theory

Leveraging Handwriting Impairment as a Biomarker for Early Parkinson’s Disease Diagnosis

Cerebellar oscillatory dysfunction during lower-limb movement in Parkinson’s disease with freezing of gait

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