Interventions for adherence with oral chemotherapy in hematological malignancies: A systematic review

Kavookjian, Jan; Wittayanukorn, Saranrat

doi:10.1016/j.sapharm.2014.08.006

Cited by 26 publications

(37 citation statements)

References 37 publications

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“…In general, medication adherence research highlights patients' adherence with medication regimen and administration, but not on the influence of side effect self-management on medication adherence. 17,18 A better understanding of the complex relationships between medication adherence, medication side effects, and patients' self-management of side effects is needed to design and develop targeted interventions for improving adherence to OAAs. The purpose of this pilot study was to explore how patient self-reported severity of OAA-related side effects and perceived effectiveness of side effect self-management were associated with adherence to OAAs, using capecitabine as the example.…”

Section: Introductionmentioning

confidence: 99%

<p>Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents</p>

Jiang¹,

Wickersham²,

Zhang³

et al. 2020

PPA

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Purpose: There are growing concerns about patients' adherence to oral anticancer agents (OAAs), and the need for patients to engage in self-management of OAA-related side effects. We assessed associations among adherence, severity of side effects, and effectiveness of self-management of side effects in patients taking capecitabine. Methods: Adherence to capecitabine at 6 weeks was measured by the Medication Event Monitoring System among 50 patients with gastrointestinal cancers. Severity of side effects related to capecitabine and effectiveness of self-management of side effects were captured using the Modified Self-Care Diary at the time of enrollment and weekly for 6 weeks. Spearman's correlation, Mann-Whitney U-tests, and multiple linear regression were conducted, p<0.05. Results: Overall mean adherence rate was 85.4±14.1%. Adherence rate was not significantly correlated to the mean severity of total side effects at any time point and was correlated with the mean effectiveness of self-management of total side effects only at week 2 (rho=0.29, p=0.04). However, adherence rate was associated with the mean severity of one specific side effect, diarrhea, at 6 weeks (rho=0.36, p=0.01) and marginally correlated to the mean effectiveness of self-management of diarrhea at 6 weeks (rho=0.28, p=0.05). Mean severity of diarrhea at 6 weeks was an independent predictor of adherence rate (b=4.97, p=0.01), with the control of age (b=0.52, p=0.002), number of outpatient medications (b=1.12, p=0.007), health literacy (b=2.53, p=0.04), diagnosis of colorectal cancer (b=11.6, p=0.03), and capecitabine in combination with other chemotherapies (b=16.8, p=0.001) in the model. Conclusion: This pilot study suggests ongoing examination of both severity and effectiveness of self-management of side effects in future studies of adherence to OAAs is merited. There is a need for future studies with larger sample sizes that explore the complex relationships among adherence, severity of side effects, and effectiveness of self-management of side effects in OAA therapy.

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Section: Introductionmentioning

confidence: 99%

<p>Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents</p>

Jiang¹,

Wickersham²,

Zhang³

et al. 2020

PPA

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“…İncelediğimiz çalışmalar, çok farklı örneklem büyüklüğünde ve sürelerinde gerçekleştirilmesine rağmen, sonuçlar kanser hastalarında ilaç uyumunda problem yaşanabildiğini göstermiştir. Literatürdeki çalışmalar, kronik hastalarda uzun dönem tedavide ilaç uyumunun %50-70 oranında olduğunu göstermektedir 11,28,29 . Weingard ve arkadaşlarının 1999-2007 yılları arasında oral kemoterapik ilaç kullanımıyla ilgili 508 vakanın incelediği çalışmada, yanlış ilaç kullanımına bağlı; hastaların %2,4'ünde ölüm, %4,1'inde hastaneye yatış ve %80,7'sinde minimal zarar geliştiği görülmüştür.…”

Section: Discussionunclassified

Oral Antikanser İlaç Kulanan Kanser Hastalarında Telefon ile Yapılan İzlemin İlaç Uyumuna Etkisi: Sistematik Derleme

Çakmak

Kapucu

2018

Hacettepe Üniversitesi Hemşirelik Fakültesi Dergisi

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Kanser görülme sıklığının artması ile beraber, tedavi yöntemleri de gelişmiştir. Bu gelişmelerden biride kemoterapik ilaçların oral formlarının artmasıdır. Bu çalışmada, oral antikanser ilaç kullanan kanser hastalarında telefon ile yapılan izlemin ilaç uyumuna etkisinin sistematik olarak incelenmesi amaçlanmıştır. Gereç ve Yöntem: Oral antikanser ilaç kullanan kanser hastalarında telefon ile yapılan izlemin ilaç uyumuna etkisini ortaya koyabilmek için, 2007 ile 2017 Ocak tarihleri arasında yayınlanmış 4858 çalışma taranmıştır. Araştırma kriterlerine uyan yedi çalışma incelenmiştir. Seçilen araştırmalar, türlerine göre Joanna Briggs Enstitüsü (JBI) eleştirel değerlendirme listelerine göre değerlendirilmiştir. Bulgular: Araştırmada incelenen yedi çalışmanın (prospektif çalışma: 1, tanımlayıcı çalışma: 2, Kohort çalışma: 1, randomize kontrollü çalışma: 1, yarı deneysel çalışma: 2) kalitesi orta derecede bulunmuştur. İncelenen makalelerde hastaların ilaç uyumunu etkileyici faktörlerin ve uyumun ölçülmesine yönelik yöntemlerin belirsiz ve ortak olmadığı saptanmıştır. Ayrıca çalışmalarda ilaç uyumu oranları, hasta örneğine, ilaç türüne, takip periyoduna, değerlendirme ölçüsüne ve uyum hesaplanmasına bağlı olarak çeşitlilik gösterdiği belirlenmiştir. Sonuç: Telefon ile izlemin oral kemoterapi kullanan hastalarda ilaç uyumunu artırma konusunda kanıtlar sınırlı kalmaktadır. İleride yapılacak kaliteli çalışmalara ihtiyaç vardır. Sağlık ekibi hasta eğitimi, hastaların tedavi planlarını gözden geçirmek ve belgelemek, oral kemoterapi ilaç kullanımı uyumu için rutin hasta izlemi konularında standart prosedürler geliştirmelidir.

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“…Nonadherence is problematic for several reasons. Treatment adherence is one of the most salient predictors of patient survival, and poor adherence can result in drug resistance (Kavookjian & Wittayanukorn, 2015), low response rate (Marin et al, 2010), earlier and more frequent disease progression (Kavookjian & Wittayanukorn, 2015), and, ultimately, a greater risk of death (Richardson, Shelton, Krailo, & Levine, 1990). Nonadherence may also negatively affect healthcare providers' ability to determine treatment safety and efficacy (Ruddy et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, poor adherence contributes to increased healthcare costs and can lead to worsening of disease and decreased overall patient survival (Bestvina et al, 2014; Servick, 2014; Soria et al, 2011). Rates of adherence to OAMs are often less than 80%, with 10% of patients with cancer documented as not having refilled their OAM prescriptions (Kavookjian & Wittayanukorn, 2015; Puts et al, 2014; Spoelstra & Given, 2011; Streeter, Schwartzberg, Husain, & Johnsrud, 2011). …”

mentioning

confidence: 99%

The Association Between Patient-Reported and Objective Oral Anticancer Medication Adherence Measures: A Systematic Review

Atkinson¹,

Rodríguez²,

Gordon³

et al. 2016

ONF

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Problem Identification Oral anticancer medication (OAM) use has been steadily increasing, leading to several patient benefits. A notable challenge for nurses is accurate monitoring of patient OAM regimens because nonadherence is associated with poor health outcomes and decreased survival. Currently, no gold standard measure of OAM adherence exists. The authors conducted a systematic review of the association between objective and patient-reported measures of OAM adherence. Literature Search A systematic electronic literature search was conducted using PubMed, EMBASE, Scopus, PsycINFO®, Cochrane Library, Web of Science, and CINAHL® databases through November 2014. Data Evaluation Articles were independently reviewed to determine whether they included an original characterization of the level of association between objective and patient-reported measures of OAM adherence. Synthesis From a total of 11,135 articles retrieved, eight studies met inclusion criteria. Objective adherence was primarily assessed using pill counts or Medication Event Monitoring System (MEMSCap™). Patient-reported adherence was most commonly assessed using study-specific questionnaires. Significant positive correlations were observed between objective and patient-reported adherence across most studies, with three studies reporting higher rates of adherence via patient reporting. Conclusions Despite variation in the OAMs and measures used, patient-reported adherence rates were equal to or higher than objective adherence measures across studies. Social desirability bias may be a concern; however, given the significant concordance observed, using patient-reported methods in future studies of OAM adherence may be justified. Implications for Nursing This review provides evidence to support nursing use of patient-reported measures to accurately monitor OAM adherence and potentially improve the quality of patient–provider communication.

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Interventions for adherence with oral chemotherapy in hematological malignancies: A systematic review

Cited by 26 publications

References 37 publications

<p>Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents</p>

<p>Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents</p>

Oral Antikanser İlaç Kulanan Kanser Hastalarında Telefon ile Yapılan İzlemin İlaç Uyumuna Etkisi: Sistematik Derleme

The Association Between Patient-Reported and Objective Oral Anticancer Medication Adherence Measures: A Systematic Review

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