Interventions for minimal change disease in adults with nephrotic syndrome

Glomerular disease search filters for Pubmed, Ovid Medline, and Embase: a development and validation study

“…We developed unique filters for PubMed, Ovid Medline, and Embase. We obtained the search terms used for filter development from the following sources: US National Library of Medicine (NLM) medical subject heading (MeSH) thesaurus using Medline MeSH browser [ 22 ], Medline permuted index [ 23 ], Emtree thesaurus [ 24 ], SNOMED clinical terms, nephrology textbooks [ 25 ], clinical practice guidelines [ 26 , 27 ], systematic reviews [ 28 - 33 ], website glossaries, and clinician and librarian opinion. All terms considered potentially useful by any member of our team were included.…”

“…To illustrate the potential effectiveness of validated filters in PubMed, we selected six independent nephrologists from a directory of Canadian nephrologists provided by the Royal College of Physicians and Surgeons of Canada to execute a search for a unique predetermined clinical question. We formulated six clinical questions, each which could be answered by a recent corresponding systematic review [ 28 - 33 ]. These systematic reviews were then used as a reference source for relevant articles on the given topic.…”

Nephrotic syndrome in adults: symptoms and management

“…The quality of the evidence from the few RCTs that examine the treatment of the first episode of MCD in adults with NS with corticosteroids is low (Table S24 and Table S25 271,[279][280][281] ). These RCTs only include a small number of participants and have various study limitations that place them at a high risk of bias.…”

Chapter 5: Minimal-change disease in adults

“…However, patients treated with prednisone went into remission more rapidly; 12 of 14 treated patients were in complete remission before 2 months, compared to 6 of 14 controls. 124 , 136 …”