Interventions for preventing critical illness polyneuropathy and critical illness myopathy

Hermans, Greet; Jonghe, Bernard De; Bruyninckx, Frans; Berghe, Greet Van den

doi:10.1002/14651858.cd006832.pub2

Cited by 99 publications

(118 citation statements)

References 62 publications

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“…They were also at risk of hypoventilation and type 2 respiratory failures. 22,23 Similar findings were reported in patients with severe head trauma. 24,25 In our cohort, patients with neurological diseases constituted the highest proportion of readmissions.…”

Section: Discussionsupporting

confidence: 82%

Characteristics of patients readmitted to intensive care unit: a nested case-control study

et al. 2014

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Section: Discussionsupporting

confidence: 82%

Characteristics of patients readmitted to intensive care unit: a nested case-control study

et al. 2014

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“…In addition, corticosteroids are the main determinants of impaired ability to exercise at 3 months in patients with critical illness myopathy [5]. After the first case report of profound frailty in asthma patients treated with corticosteroids and neuromuscular blocking agents [45], many similar findings were reported indicating that these two substances [28,46] contribute to CIP/CIM or ICUAW. In animal studies, denervated and steroid-treated animals showed muscle changes similar to those observed in critical patients [47].…”

Section: Risk Factors For Icuawmentioning

confidence: 94%

Skeletal Muscle Dysfunction in Critical Illness

Iida¹,

Sakuma²

2017

Physical Disabilities - Therapeutic Implications

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Despite improvements in critical illness survival rates with recent developments in medical care, many patients still have long-term physical disabilities following stays in the intensive care unit (ICU). Critical illness-induced muscle weakness, so-called ICU-acquired weakness (ICU-AW), is a common occurrence in approximately 50% of critically ill patients in the ICU requiring mechanical ventilation for >7 days. ICU-AW contributes to increases in duration of mechanical ventilation and lengths of ICU and hospital stays and may persist among survivors for several years after discharge. Risk factors for ICU-AW include systemic inflammatory responses, severe sepsis, muscle inactivity, hyperglycemia, and use of neuromuscular blockers. Thus, the development of muscle wasting is suggested to be associated with pathophysiological alterations leading to an imbalance between muscle proteolysis and proteosynthesis through several cellular signaling networks. This chapter presents a review of the literature regarding critical illness-induced muscle wasting and describes potential treatment of excessive muscle catabolism.

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“…Protein and energy depletion that can occur in critical illness has been associated with poorer functional outcomes for patients including muscle weakness (Vivodtzev et al, 2014), myopathy and polyneuropathy (Hermans et al, 2014). The prevalence of malnutrition is substantial and although a universally accepted approach to determining malnutrition is lacking, it is estimated that 15-60% of adults might be malnoursished (White et al, 2012).…”

Section: Nutritional Statusmentioning

confidence: 99%