Interventions for preventing neuropathy caused by cisplatin and related compounds

Albers, James W.; Chaudhry, Vinay; Donehower, Ross C.; Cavaletti, Guido

doi:10.1002/14651858.cd005228

Cited by 40 publications

(63 citation statements)

References 28 publications

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“…There are some reports related to preventative compounds against cisplatin induced neuropathy but the data are insufficient to conclude determination of any neuroprotective agent's to date [5,6]. Acetyl-L-carnitine (ALC) is a member of the family of carnitines, a group of natural compounds that have an essential role in intermediary metabolism and facilitates the entry and exit of essential fatty acids from the mitochondria [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Acetyl-l-Carnitine on Cisplatin Cytotoxicity and Oxidative Stress in Neuroblastoma

et al. 2009

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The most widely used platinum-derived drug is cisplatin in neuroblastoma (NB) chemotherapy, which is severely neurotoxic. Acetyl-L-Carnitine (ALC) is a natural occurring compound with a neuroprotective activity in several experimental paradigms. The aim of this study was to determine the effects of ALC on cisplatin induced cytotoxicity and oxidative stress in NB cells. SH-SY5Y (N-Myc negative) and KELLY (N-Myc positive) human NB cell lines were used. Cisplatin induced apoptosis was assessed by using a Cell Death Detection ELISA(PLUS) kit. Lipid peroxidation levels were determined by HPLC analysis. Glutathione levels were determined spectrophotometrically. ALC was used prophylactic or after cisplatin application. The level of cisplatin doses were determined in both type of NB cells at which 50% cell death occurred along with synchronized apoptosis induced. Prophylactic 10 and 50 micromol of ALC concentrations were decreased cisplatin induced lipid peroxidation compared to controls that normally exhibited apoptosis especially in SH-SY5Y cells. Cisplatin caused oxidative stress through decreasing glutathione levels in both cell types. ALC were effectively inhibited the increase in cisplatin induced oxidized glutathione and lipid peroxidation formation in NB cells. We suggested that prophylactic ALC would be a useful agent for cisplatin induced toxicity in NB cells.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Acetyl-l-Carnitine on Cisplatin Cytotoxicity and Oxidative Stress in Neuroblastoma

et al. 2009

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“…A 2013 Cochrane Database Systematic Review on preventing cisplatin-induced neuropathy reported that although studies of amifostine, calcium plus magnesium, glutathione, and vitamin E reported borderline benefits in patients as assessed by subjective measures, none had been shown to improve quantitative measures of nerve function [45]. At the same time, the utility of currently available quantitative measures for assessing cancer-related neuropathy has not been established; it is not clear whether there is a strong correlation between symptoms and quantitative measures [46].…”

Section: Peripheral Neuropathy Ototoxicity and Raynaud-like Phenomenamentioning

confidence: 99%

“…There are 2 small controlled studies that have reported significant reductions in symptoms using 300 to 600 mg of vitamin E daily, although they did not use a validated scale [47,48]. The Cochrane review pooled the results of these 2 studies are reported a lower rate of neuropathy in the vitamin E-treated group when compared with controls, as measured by a total neuropathy scale at trial end (9 of 29 receiving vitamin E compared with 25 of 33 controls, risk ratio = 0.41, 95% CI: 0.23-0.73) [45]. The small size of these trials and the failure to use a placebo-controlled design limits the meaningfulness of these results.…”

Section: Peripheral Neuropathy Ototoxicity and Raynaud-like Phenomenamentioning

confidence: 99%

Quality of life among testis cancer survivors

Gilligan

2015

Urologic Oncology: Seminars and Original Investigations

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“…& Several other compounds have been evaluated in CIPN models, and some of them deserve to be mentioned because they could represent interesting candidates for future clinical testing [43,44]. & Acetyl-L-carnitine has shown promising results in several animal models of CIPN induced by oxaliplatin, cisplatin, paclitaxel, and vincristine.…”

Section: Other Compoundsmentioning

confidence: 99%

Chemotherapy-Induced Neuropathy

Cavaletti

Alberti

Frigeni

et al. 2010

Curr Treat Options Neurol

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Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most severe and unpredictable side effects of modern anticancer treatment. In recent years, a clear understanding of the importance of an integrated approach to CIPN has become evident, and efforts are increasing to better characterize its features and to identify more accurate methods to report and grade its occurrence. The clinically relevant impact of CIPN on cancer patients has been known for a long time, but knowledge of its pathogenetic aspects is still very limited. This incomplete knowledge is one of the major limitations in identifying targets for evidence-based neuroprotective strategies. Nevertheless, several studies have been devoted to the prevention or at least the effective treatment of symptoms secondary to peripheral nerve damage and to the early identification of patients at high risk of developing severe CIPN. Unfortunately, none of these studies has been successful and the optimal management of CIPN patients is still an unmet clinical need. Therefore, the modification of chemotherapy is currently the only available approach to limit the severity of neuropathy in the vast majority of patients. The indications for treatment modification are not universally accepted and they can differ among the various drugs. Generally, treatment modification should be considered as soon as symptoms and signs impair the daily life activities of the patient, but the possibility of a delayed worsening of CIPN after treatment withdrawal ("coasting") should always be considered, and delay of modification decisions should be avoided.

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Interventions for preventing neuropathy caused by cisplatin and related compounds

Cited by 40 publications

References 28 publications

Protective Effects of Acetyl-l-Carnitine on Cisplatin Cytotoxicity and Oxidative Stress in Neuroblastoma

Protective Effects of Acetyl-l-Carnitine on Cisplatin Cytotoxicity and Oxidative Stress in Neuroblastoma

Quality of life among testis cancer survivors

Chemotherapy-Induced Neuropathy

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