Interventions for preventing oral mucositis for patients with cancer receiving treatment

Worthington, Helen V; Clarkson, Jan E; Bryan, Gemma; Furness, Susan; Glenny, Anne‐Marie; Littlewood, Anne; McCabe, Martin; Meyer, Stefan; Khalid, Tasneem

doi:10.1002/14651858.cd000978.pub4

Cited by 70 publications

(34 citation statements)

References 280 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…46 Similarly, oral or intravenous glutamine can reduce the severity of mucositis, but clinical evidence for its efficacy in preventing infections is lacking. 47,48 Without any specific interventions, mucosal damage starts to heal just before, or with the recovery of granulocytes in peripheral blood (PB), 49 as neutrophil recruitment to the site of mucosal injury may occur up to a week before recovery of neutrophils in PB. 50,51 Reconstitution of the innate cellular immune system…”

Section: Recovery Of Mucosal Injurymentioning

confidence: 99%

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

2016

View full text Add to dashboard Cite

Infection is the leading cause of non-relapse mortality after allogeneic haematopoietic cell transplantation (HCT). This occurs as a result of dysfunction to the host immune system from the preparative regimen used prior to HCT, combined with a delay in reconstitution of the donorderived immune system after HCT. In this article, we elaborate on the process of immune reconstitution post-HCT that begins with the innate system and is followed by recovery of adaptive immunity. Simultaneously, we describe how the tempo of immune reconstitution influences the risk of various infections. We explain some of the key differences in immune reconstitution and the consequent risk of infections in recipients of peripheral blood stem cell, bone marrow or umbilical cord blood grafts. Other factors that impact on immune recovery are also highlighted. Finally, we allude to various strategies that are being tested to enhance immune reconstitution post-HCT.

show abstract

Section: Recovery Of Mucosal Injurymentioning

confidence: 99%

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

2016

View full text Add to dashboard Cite

show abstract

“…73 A total of 131 studies with 10 514 randomised participants were included. Nine interventions, in which there was more than one trial in the meta-analysis, were found to have some benefit with regard to preventing or reducing the severity of mucositis associated with cancer treatment, and aloe vera was involved in one of them.…”

Section: Aloe Vera Anti-inflammatory and Gastrointestinal Actionsmentioning

confidence: 99%

Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials

Williamson

Coppens²,

Serra-Majem

et al. 2011

Food Funct.

View full text Add to dashboard Cite

We assess the evidence for health benefits of three commonly consumed plant food supplements (PFS), green tea, isoflavone and aloe vera, based on published systematic reviews of randomised controlled trials (RCTs). Whilst the potential benefits of green tea have been reported in a wide range of health areas, it is only in the area of the metabolic syndrome that the number of RCTs is approaching sufficient to judge such efficacy. Isoflavone supplements are widely used, and RCTs indicate that they affect bone resorption at lower doses in postmenopausal women undergoing estrogen-related bone loss, but this is only translated to attenuation of bone loss at higher doses of isoflavones. A systematic review on RCTs concluded that the effects of isoflavones on hot flashes in postmenopausal women were highly variable and no conclusions could be drawn. Despite the popularity of aloe vera as a PFS, the evaluation of its efficacy as a coadjuvant therapy for certain metabolic or digestive pathologies remains scarce; it constitutes a typical example of a naturally occurring ingredient whose efficacy in topical applications presupposes its efficacy in systemic applications. Nevertheless, its possible toxic effects on oral consumption call for caution in its utility as a PFS. Since 2007, efficacy evaluation of PFS in Europe has been covered by European Union Nutrition and Health Claims legislation. The European Food Safety Authority has adopted an approach relying on RCTs, while medicinal effects are accepted based on traditional use. In general, there are insufficient RCTs for claims to be made, and conclusive results on PFS should be obtained in the future by conducting studies with more homogeneous populations, by using supplements with optimised and measured bioavailability, and by conducting larger RCTs.

show abstract

“…(10) La mucositis es la reacción inflamatoria que tiene lugar en el epitelio de todo el tracto gastrointestinal, desde la boca hasta el ano, a consecuencia de los tratamientos antineoplásicos tales como la radioterapia, la quimioterapia o el trasplante de médula ósea, siendo muy frecuente en los tratamientos de los procesos oncohematológicos. (11) En la cavidad oral, con la presencia de mucositis, se ven reflejados, los cambios que ocurren en todo el recubrimiento mucoso. (6) Debemos destacar, que el paladar blando, la mucosa yugal, los labios y el piso de boca, son más vulnerables al daño tóxico directo por ser áreas de mucosa no queratinizada, si se compara con las encías, superficie dorsal de lengua y paladar duro.…”

Section: Mucositisunclassified

“…En conclusión, la crioterapia parece ser efectiva en la prevención de la mucositis inducida por quimioterapia y en concreto por los fármacos 5-FU, melfalán y edatrexato. (11)…”

Section: Modificadores De La Respuesta Biológicaunclassified

“…Aparte de esta función directa de barrera, parece ser que el sucralfato ejerce una acción protectora de la mucosa de forma indirecta al incrementar la producción local de prostaglandina E2, conduciendo a un aumento en la producción de mucus y bicarbonato y a un incremento del flujo sanguíneo y de la actividad mitótica de la mucosa. (11) Todos estos efectos justificarían la utilidad de este fármaco en la prevención y tratamiento de la mucositis asociada a quimioterapia y radioterapia. En dos estudios piloto se han observado resultados positivos tras el uso de sucralfato en mucositis inducida por quimioterapia Igualmente los resultados preliminares de un ensayo en fase III sugieren superioridad de una solución de sucralfato frente a una solución de difenhidramina + antiácidos + lidocaína.…”

Section: Sucralfatounclassified

See 1 more Smart Citation

Posibles efectos profilácticos del té verde en mucositis por tratamiento quimioterápico

Barilaro¹

View full text Add to dashboard Cite

La mucositis oral es uno de los efectos secundarios más frecuentes del tratamiento oncológico. Puede causar la interrupción del tratamiento, afectar la calidad de vida e incluso el fracaso de la terapia. El objetivo de este trabajo es determinar la efectividad clínica del té verde en la prevención y/o tratamiento de la mucositis en pacientes con cáncer bajo tratamiento quimioterápico. Se realizó un estudio transverso en pacientes que concurrieron para recibir quimioterapia al Servicio de Oncología del Hospital “Alejandro Korn”. La muestra estuvo representada por 100 pacientes a los que se les realizó, antes del tratamiento oncológico, una terapia básica profiláctica por medio del Índice de O’Leary y enseñanza de cepillado. Se dividió la muestra en 2 grupos de 50 pacientes cada uno, grupo A: se les indicó colutorios de té verde y grupo B: de control. En el grupo A se observó que 84% (42/50) presentaron mucositis siendo el grado más frecuente el G1a. En el grupo B se observó que 26% (13/50) presentaron mucositis siendo el grado más frecuente el G1a. Los resultados permitirían establecer que, para la muestra estudiada, el colutorio de té verde disminuiría la prevalencia y el grado de las mucositis provocadas por quimioterapia.

show abstract

Interventions for preventing oral mucositis for patients with cancer receiving treatment

Cited by 70 publications

References 280 publications

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials

Posibles efectos profilácticos del té verde en mucositis por tratamiento quimioterápico

Contact Info

Product

Resources

About