Interventions to chronic prostatitis/Chronic pelvic pain syndrome treatment. Where are we standing and what's next?

Santharam, Madanraj Appiya; Khan, Farhan Ullah; Naveed, Muhammad; Ali, Usman; Ahsan, Muhammad Zaeem; Khongorzul, Puregmaa; Shoaib, Rana Muhammad; Ihsan, Awais Ullah

doi:10.1016/j.ejphar.2019.172429

Cited by 20 publications

(22 citation statements)

References 177 publications

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“…The current methods of treating CP/ CPPS include antibiotics, alpha blockers, phosphodiesterase inhibitors, 5-α reductase inhibitors and so on (4). Additionally, physiotherapy has been shown to be effective in relieving symptoms of CP/CPPS, such as acupuncture (5), low-intensity extracorporeal shock wave therapy (Li-ESWT) (6) and circumcision (4).…”

Section: Introductionmentioning

confidence: 99%

Study on the relationship between sex hormone changes and erectile dysfunction in patients with chronic prostatitis/chronic pelvic pain syndrome

et al. 2021

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Background: To investigate the relationship between serum sex hormones and erectile dysfunction (ED), changes in erectile function and sex hormones were studied in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).Methods: A total of 171 patients with CP/CPPS who met the inclusion criteria from January 2016 to June 2019 were retrospectively analyzed. The level of patient's testosterone (TT), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), premature ejaculation diagnostic tool (PEDT) score and international index of erectile function (IIEF-5) score were separately observed and compared.Results: Among 171 eligible patients, 131 (76.61%) cases were diagnosed as ED and 40 (23.39%) cases were normal. Between the ED and No-ED groups, the PRL and PEDT score were statistically significant (P<0.01) based on the test results. ED-dependent and PEDT-dependent receiver operating characteristic (ROC) analysis and decision curve analysis (DCA) were performed on different degrees of ED to determine the predictive performance and clinical applicability. The results showed that PRL can better predict the possibility of ED in CP/CPPS patients than PEDT.Conclusions: For CP/CPPS patients, the Prolactin level decreases as the degree of ED increases.Prolactin can be used as a predictor to better predict the possibility of ED in CP/CPPS patients.

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Section: Introductionmentioning

confidence: 99%

Study on the relationship between sex hormone changes and erectile dysfunction in patients with chronic prostatitis/chronic pelvic pain syndrome

et al. 2021

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“…Local inflammation of the prostate, abnormal neurological function, and mental health problems can all cause the local excitability of α receptors. This then causes up-regulation of the expression of urethral subtype receptors, causing urine reflux to the prostate resulting in chemical infection of the prostate (19,20). About 90% of the receptors in the prostate are type α1 androgenic (21,22) receptors, which are widely distributed in the smooth muscle of the prostate matrix, the posterior membrane of the urethral mucosa, and the capsule.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis: α-adrenergic receptor blockers in chronic prostatitis

Deng¹,

Du²,

Zhou³

et al. 2021

Ann Palliat Med

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Background: Prostatitis seriously endangers the health of men. While they have been widely used in recent years, there remains a lack of systematic evaluation of the clinical efficacy of α-receptor blockers (α-RBs)/α-adrenergic receptor blockers (α-ARBs) in its treatment. Based on this, this study was developed to systematically evaluate the clinical effect of α-ARB in the treatment of prostatitis.Methods: Randomized controlled trials (RCTs) studying α-RBs or α-ARBs, placebos, or other measures to treat prostatitis were searched in Cochrane Library, PubMed, Embase, and CBM databases from establishment to December 2020. The quality of included articles was evaluated using the Cochrane System Review Manual and Jadad tools, and a meta-analysis was performed using Review Manager 5.3 software. Results: A total of six articles meeting the requirements were found and included 450 patients. Metaanalysis showed that the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score [mean difference (MD) =−1.76, 95% confidence interval (CI): (−3.35 to −0.17), and P=0.03], pain score [MD =−2.24, 95% CI: (−3.65 to −0.83), and P=0.002], voiding symptom score [MD =−1.21, 95% CI: (−2.06 to −0.35), and P=0.006], and quality of life score [MD =−1.40, 95% CI: (−1.48 to −1.33), and P<0.00001] for patients in the experimental group were lower in contrast to those in the control group after the treatment.Discussion: The use of α-ARB could significantly improve the treatment effect of patients with prostatitis and improve their quality of life.

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“…[ 9 – 10 ] Modern medical interventions for CP mainly include alpha-blockers, antibiotics, analgesics, and multimodal therapy. [ 11 – 13 ] However, its therapeutic effect is limited, and there is currently no good strategy to relieve the symptoms of CP/CPPS. Anti-inflammatory drugs to treat CP are easy to cause serious side effects of gastrointestinal and cardiovascular diseases, and the efficacy is not significant.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and safety of acupuncture combined with traditional Chinese medicine in the treatment of chronic prostatitis

Lin

et al. 2021

Medicine

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Objective: Chronic prostatitis (CP) is a common disease in the outpatient department of males and urology. Clinical studies have found that acupuncture combined with traditional Chinese medicine (TCM) has achieved good results in treating CP, but its efficacy and safety are not completely clear. This study aimed to investigate the efficacy and safety of acupuncture combined with TCM in the treatment of CP. Methods: Randomized controlled trials of acupuncture combined with TCM in treating CP were screened by searching PubMed, Embase, Cochrane Library, CNKI, etc. The retrieval time was from the database establishment date to March 31, 2021. The Cochrane Collaborative Risk Bias Assessment tool was used to evaluate literature's methodological quality of the literature. The RevMan5.4 software was used for the meta-analysis of outcome indicators. The TSA v0.9 software was used for sequential trial analysis (TSA) of effectiveness. Results: In this study, 19 related randomized controlled trial studies were included, with a total of 1831 cases. The results of the meta-analysis showed that acupuncture combined with TCM could significantly improve the clinical efficacy of CP (OR = 3.76, 95%CI: 2.82 to 5.02, P < .00001), reduce the total score of The National Institutes of Health chronic prostatitis symptom index (MD = −4.00, 95%CI: −4.67 to 3.33, P < .00001), and improve patients’ urination symptoms (MD = −1.10, 95%CI: −1.23 to −0.97, P < .00001), alleviated the pain symptoms of patients (MD = −2.38, 95%CI: −2.41 to −2.35, P < .00001), improved the quality of life of patients (MD = −1.69, 95%CI: −1.97 to −1.41, P < .00001), decreased the scores of TCM symptoms of patients (MD = −2.39, 95%CI: −3.45 to −1.33, P < .00001), and did not increase the adverse reactions of patients (MD = 1.09, 95%CI: 0.57 to 2.06, P = .8). The results of publication bias showed that this study was not affected by publication bias, and the conclusion was reliable. TSA showed that acupuncture combined with TCM was effective in treating CP. Conclusion: Acupuncture combined with TCM is safe and effective for alleviating CP. It can be used as an effective treatment for chronic prostatitis in the clinic. Registration number: DOI 10.17605/OSF.IO/Z8FJM.

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Interventions to chronic prostatitis/Chronic pelvic pain syndrome treatment. Where are we standing and what's next?

Cited by 20 publications

References 177 publications

Study on the relationship between sex hormone changes and erectile dysfunction in patients with chronic prostatitis/chronic pelvic pain syndrome

Study on the relationship between sex hormone changes and erectile dysfunction in patients with chronic prostatitis/chronic pelvic pain syndrome

Systematic review and meta-analysis: α-adrenergic receptor blockers in chronic prostatitis

Effectiveness and safety of acupuncture combined with traditional Chinese medicine in the treatment of chronic prostatitis

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