Intervertebral discs degeneration and methods of its biological correction

Vasilyeva, I. G.; Khyzhnyak, Mykhaylo; Shuba, Irina; Gafiychuk, Yu. G.

doi:10.25305/unj.88759

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…The use of NP material selected at the time of microdiscectomy may be one of the approaches to obtaining cells for in vitro cultivation. However, the possibility of introducing autologous cultured cells or implants after surgery in IVDs is debatable [16]. The simplest approach to repair degenerating IVD using autologous cultured cells is the injection of cells grown ex vivo [17].…”

Section: Implantation Of Autologous Cultured Cellsmentioning

confidence: 99%

“…Despite the positive results of the use of injection methods of IDD therapy in humans, when a toxic microenvironment is formed, there is a decrease in the supply of glucose and oxygen nutrients, as well as an "acidification" of the environment, and the question remains of how long the expression of a genetically engineered construct is possible under these conditions [16].…”

Section: Gene Modificationsmentioning

confidence: 99%

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High-Tech Methods of Cytokine Imbalance Correction in Intervertebral Disc Degeneration

Shnayder,

Ashhotov,

Trefilova

et al. 2023

IJMS

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An important mechanism for the development of intervertebral disc degeneration (IDD) is an imbalance between anti-inflammatory and pro-inflammatory cytokines. Therapeutic and non-therapeutic approaches for cytokine imbalance correction in IDD either do not give the expected result, or give a short period of time. This explains the relevance of high-tech medical care, which is part of specialized care and includes the use of new resource-intensive methods of treatment with proven effectiveness. The aim of the review is to update knowledge about new high-tech methods based on cytokine imbalance correction in IDD. It demonstrates promise of new approaches to IDD management in patients resistant to previously used therapies, including: cell therapy (stem cell implantation, implantation of autologous cultured cells, and tissue engineering); genetic technologies (gene modifications, microRNA, and molecular inducers of IDD); technologies for influencing the inflammatory cascade in intervertebral discs mediated by abnormal activation of inflammasomes; senolytics; exosomal therapy; and other factors (hypoxia-induced factors; lysyl oxidase; corticostatin; etc.).

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Section: Implantation Of Autologous Cultured Cellsmentioning

confidence: 99%

Section: Gene Modificationsmentioning

confidence: 99%

High-Tech Methods of Cytokine Imbalance Correction in Intervertebral Disc Degeneration

Shnayder,

Ashhotov,

Trefilova

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Наименее изученными остаются вопросы строения межклеточного вещества МПД и содержание химических элементов в них при дегенеративных процессах. Дегенерация МПД происходит гораздо раньше, чем других тканей позвоночного двигательного сегмента (ПДС), первые однозначные ее признаки в поясничном отделе позвоночника обнаружены в возрастной группе 11-16 лет [5][6][7].…”

Section: Introductionunclassified

Macro- and microelement content of intervertebral discs in hernias of the lumbar spine

Kochkartaev¹,

Shatursunov²,

Данилова³

et al. 2020

ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS

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Intervertebral discs degeneration and methods of its biological correction

Cited by 2 publications

References 36 publications

High-Tech Methods of Cytokine Imbalance Correction in Intervertebral Disc Degeneration

High-Tech Methods of Cytokine Imbalance Correction in Intervertebral Disc Degeneration

Macro- and microelement content of intervertebral discs in hernias of the lumbar spine

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