Intestinal abnormalities in murine giardiasis

Ferguson, Anne; Gillon, J.; Thamery, D. Al

doi:10.1016/0035-9203(80)90049-8

Cited by 18 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The criteria used to evaluate these effects are villus height, crypt depth and intraepithelial lymphocyte counts, all of which have been shown to be indirect measures of local intestinal cell-mediated immunity (Ferguson & MacDonald, 1977). The changes in the intestinal mucosa found to be associated with both G. muris and S. muris are similar to those described by previous workers for G. muris (Roberts-Thomson, Stevens, Mahmoud & Warren, 1976;Ferguson, Gillon & Al Tharnery, 1980). Evidence that these intestinal changes may be incidental to the immune response to G. muris comes from experiments with congenitally athymic mice in which it was found that the reduction in villus: crypt ratio was more severe in normal BALB/c (nu/ + ) than in nude (nu/nu) mice (Roberts-Thomson & Mitchell, 1978).…”

Section: W)supporting

confidence: 61%

“…As a result of all the evidence available it has been suggested that changes in the architecture of the small intestine during infections with intestinal flagellates result from the combined effects of damage to the enterocytes by the parasites and local cell-mediated responses (Ferguson et al 1980). The role of intra-epithelial lymphocytes in the immune response to intestinal flagellates is unclear but an increase in numbers does occur at the same time as the parasites begin to be eliminated.…”

Section: W)mentioning

confidence: 99%

See 1 more Smart Citation

Immunological aspects ofGiardia murisandSpironucleus murisinfections in inbred and outbred strains of laboratory mice: a comparative study

Brett

Cox

1982

Parasitology

View full text Add to dashboard Cite

The intestinal flagellates, Giardia muris and Spironucleus muris, cause similar infections in CBA mice as determined by trophozoite and cyst counts. Both parasites occur all along the small intestine with G. muris, being mainly present in the anterior part and S. muris towards the posterior. The early stages of infection are similar in all strains of mice examined and peak levels of both trophozoites and cysts occur 1-2 weeks after infection. All strains of mice overcome the infection but the rate of recovery varies considerably between strains, being most rapid in BALB/c and slowest in A and C57BL.B10. Outbred mice are more variable in their recovery than inbred mice. After recovery, mice are partially resistant to reinfection with the homologous but not the heterologous parasite. Resistance to reinfection with S. muris is greatest in those strains that eliminate the primary infection most rapidly. Giardia muris and S. muris cause similar changes in the mucosa of the small intestine of BALB/c mice with increased intra-epithelial lymphocyte counts from 3 weeks onwards corresponding with the start of the elimination of the parasites from the gut. A reduction in villus height and increase in crypt depth is also characteristic of these infections.

show abstract

Section: W)supporting

confidence: 61%

Section: W)mentioning

confidence: 99%

Immunological aspects ofGiardia murisandSpironucleus murisinfections in inbred and outbred strains of laboratory mice: a comparative study

Brett

Cox

1982

Parasitology

View full text Add to dashboard Cite

show abstract

“…The turnover of cells, i.e., the cellular nutrient content, is greatly accelerated in the murine model infected with G. muds. Ferguson et al [76] have shown a production rate of cells that is two-fold greater, without any elongation of the villi, in chronically infected mice. Acute infection significantly increased the production rates of crypt cells and cell renewal [76].…”

Section: Fecal Loss Of Endogenous Nutrients In Giardiasismentioning

confidence: 97%

“…Ferguson et al [76] have shown a production rate of cells that is two-fold greater, without any elongation of the villi, in chronically infected mice. Acute infection significantly increased the production rates of crypt cells and cell renewal [76]. The exfoliation of mucosal tissue, then, appears to be accelerated by giardial infections.…”

Section: Fecal Loss Of Endogenous Nutrients In Giardiasismentioning

confidence: 97%

Giardiasis: Nutritional Implications

Solomons¹

1982

Clinical Infectious Diseases

View full text Add to dashboard Cite

The debate about the pathogenicity of Giardia lamblia in man has ended, and the issues regarding the prevalence of clinical and subclinical infections and their nutritional impact have become the foremost considerations. Giardiasis can produce steatorrhea, maldigestion, and malabsorption of carbohydrates and of vitamins A and B 12 • The mechanisms of the absorptive dysfunction are not clear, but morphological abnormalities of the intestinal mucosa and/or bacterial overgrowth might playa role. Severe clinical giardiasis can cause "failure to thrive" in young children, but the impact, if any, of subclinical giardiasis on growth in general populations is not well defined. Proteinenergy malnutrition appears to predispose to giardial infection, perhaps because of the accompanying hypochlorhydria, immunosuppression, and altered gastrointestinal flora. The lack of a sensitive and noninvasive diagnostic test for human giardial infection limits the investigation of the nutritional correlates of giardiasis.

show abstract

Immunodepressed Animals as Models for Intestinal Protozoan Infections

Rose¹

1982

Animal Models in Parasitology

View full text Add to dashboard Cite

Intestinal abnormalities in murine giardiasis

Cited by 18 publications

References 0 publications

Immunological aspects ofGiardia murisandSpironucleus murisinfections in inbred and outbred strains of laboratory mice: a comparative study

Immunological aspects ofGiardia murisandSpironucleus murisinfections in inbred and outbred strains of laboratory mice: a comparative study

Giardiasis: Nutritional Implications

Immunodepressed Animals as Models for Intestinal Protozoan Infections

Contact Info

Product

Resources

About