Intestinal and Circulating MicroRNAs in Coeliac Disease

Felli, Cristina; Baldassarre, Antonella; Masotti, Andrea

doi:10.3390/ijms18091907

Cited by 29 publications

(22 citation statements)

References 43 publications

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“…Recent reports have demonstrated that specific miRNAs are modulated in duodenal mucosa affected by CD. The miRNAs dysregulated during the development of CD could be potentially involved in the pathogenesis of CD [6]. Overexpression or downregulation of several miRNAs could potentially stimulate or inhibit pathways related to the pathogenesis of CD.…”

Section: Introductionmentioning

confidence: 99%

Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review

et al. 2019

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Celiac disease (CD) is a multisystemic disorder with different clinical expressions, from malabsorption with diarrhea, anemia, and nutritional compromise to extraintestinal manifestations. Anemia might be the only clinical expression of the disease, and iron deficiency anemia is considered one of the most frequent extraintestinal clinical manifestations of CD. Therefore, CD should be suspected in the presence of anemia without a known etiology. Assessment of tissue anti-transglutaminase and anti-endomysial antibodies are indicated in these cases and, if positive, digestive endoscopy and intestinal biopsy should be performed. Anemia in CD has a multifactorial pathogenesis and, although it is frequently a consequence of iron deficiency, it can be caused by deficiencies of folate or vitamin B 12 , or by blood loss or by its association with inflammatory bowel disease (IBD) or other associated diseases. The association between CD and IBD should be considered during anemia treatment in patients with IBD, because the similarity of symptoms could delay the diagnosis. Vitamin B 12 deficiency is common in CD and may be responsible for anemia and peripheral myeloneuropathy. Folate deficiency is a well-known cause of anemia in adults, but there is little information in children with CD; it is still unknown if anemia is a symptom of the most typical CD in adult patients either by predisposition due to the fact of age or because biochemical and clinical manifestations take longer to appear.

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Section: Introductionmentioning

confidence: 99%

Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review

et al. 2019

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“…CD is a genetic autoimmune disorder mainly affecting the small intestine, elicited by an aberrant inflammatory response to dietary gluten proteins found in wheat, rye and barley [27,[162][163][164].…”

Section: Can Fecal Mirnas Be Celiac Disease Biomarkers Interacting Wimentioning

confidence: 99%

“…Additionally, more than 90% of human Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways contain genes that are targeted by at least one miRNA [19,25]. The partial or full complementarity of a miRNA with the mRNA target regulates the expression of target genes generally in a negative manner causing their degradation or translational inhibition [26,27]. Therefore, an upregulation of a specific miRNA generally leads to a lower expression of the protein encoded by its mRNA target, whereas the downregulation of a specific miRNA could lead to higher protein levels [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

“…The partial or full complementarity of a miRNA with the mRNA target regulates the expression of target genes generally in a negative manner causing their degradation or translational inhibition [26,27]. Therefore, an upregulation of a specific miRNA generally leads to a lower expression of the protein encoded by its mRNA target, whereas the downregulation of a specific miRNA could lead to higher protein levels [27][28][29][30]. Eukaryotic miRNAs are found in several body sites and fluids since they are secreted by most cells under both physiological and pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

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Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions

Sarshar

Scribano

Ambrosi

et al. 2020

Cancers

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Over the past decade, short non-coding microRNAs (miRNAs), including circulating and fecal miRNAs have emerged as important modulators of various cellular processes by regulating the expression of target genes. Recent studies revealed the role of miRNAs as powerful biomarkers in disease diagnosis and for the development of innovative therapeutic applications in several human conditions, including intestinal diseases. In this review, we explored the literature and summarized the role of identified dysregulated fecal miRNAs in intestinal diseases, with particular focus on colorectal cancer (CRC) and celiac disease (CD). The aim of this review is to highlight one fascinating aspect of fecal miRNA function related to gut microbiota shaping and bacterial metabolism influencing. The role of miRNAs as “messenger” molecules for inter kingdom communications will be analyzed to highlight their role in the complex host-bacteria interactions. Moreover, whether fecal miRNAs could open up new perspectives to develop novel suitable biomarkers for disease detection and innovative therapeutic approaches to restore microbiota balance will be discussed.

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“…So far, little is known about the presence of reliable circulating microRNA biomarkers to diagnose the disease or to monitor the progression or remission after a gluten-free diet. In order not to lengthen the present review with a detailed description of the studies dealing with this important pediatric disease, we collected and discussed the papers about circulating microRNAs and celiac disease in a recent paper [ 81 ].…”

Section: Circulating Micrornas In Plasma/serummentioning

confidence: 99%

Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases

Baldassarre

Felli

Prantera

et al. 2017

Genes

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MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Current studies have shown that miRNAs are also present in extracellular spaces, packaged into various membrane-bound vesicles, or associated with RNA-binding proteins. Circulating miRNAs are highly stable and can act as intercellular messengers to affect many physiological processes. MicroRNAs circulating in body fluids have generated strong interest in their potential use as clinical biomarkers. In fact, their remarkable stability and the relative ease of detection make circulating miRNAs ideal tools for rapid and non-invasive diagnosis. This review summarizes recent insights about the origin, functions and diagnostic potential of extracellular miRNAs by especially focusing on pediatric diseases in order to explore the feasibility of alternative sampling sources for the development of non-invasive pediatric diagnostics. We will also discuss specific bioinformatics tools and databases for circulating miRNAs focused on the identification and discovery of novel diagnostic biomarkers of pediatric diseases.

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Intestinal and Circulating MicroRNAs in Coeliac Disease

Cited by 29 publications

References 43 publications

Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review

Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review

Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions

Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases

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