Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

Abstract

Background: Intestinal fatty acid-binding protein 2 (FABP2) is expressed in enterocytes and binds saturated and unsaturated long-chain fatty acids. The FABP2 Ala54Thr polymorphism has been reported to effect lipid metabolism. The aim of the present study was to assess the relationship between this polymorphism and peripheral atherosclerosis combined with type 2 diabetes mellitus (T2DM) in an Egyptian population. Methods: The study was performed on 100 T2DM patients with peripheral atherosclerosis and 100 control subjects. The Ala54Thr polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism, whereas serum FABP2 levels were determined using ELISA. Fasting blood glucose, fasting serum insulin concentrations, HbA1c, lipid profile, body mass index (BMI) and systolic and diastolic blood pressure (SBP and DBP, respectively) were determined. Results: There was a higher frequency of the Thr54 allele among the patient group (P = 0.002). In Ala54/Thr54 heterozygotes and carriers of the rare Thr54/Thr54 genotype, there were significant increases in BMI and FABP2. Those with the Thr54/Thr54 genotype had significantly decreased high-density lipoprotein cholesterol (HDL-C) concentrations; in addition, those with the Thr54/Thr54 genotype had significantly higher SBP and DBP than subjects with the Ala54/Ala54 and Ala54/Thr54 genotypes. There was a positive correlation between FABP2 levels and BMI, SBP and DBP, and a negative correlation with HDL-C. Conclusions: The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied.

FABP2 Ala54Thr Polymorphism and Post-Training Changes of Body Composition and Biochemical Parameters in Caucasian Women

“…Fisher et al, (2006) showed that German women with the Thr54 allele have higher BMI and suggested that the Thr54 allele is an effect-modifier for BMI in females [ 13 ]. These results are supported by Khattab et al, (2017) who indicated that both the Ala54/Thr54 heterozygotes and carriers of the rare Thr54/Thr54 genotype had significantly higher BMI among an Egyptian population [ 24 ]. The presence of the Thr54/Thr54 homozygotes was also significantly associated with obesity in a study of 430 Caucasians of Greek ethnic origin.…”

“…Numerous investigators have also looked for associations between the specific FABP2 genotype and a variety of biochemical parameters [ 7 , 16 , 24 , 27 , 28 , 29 ]. Previously, Baier et al, (1995) revealed that the Thr54-containing protein may increase absorption and/or processing of fatty acids in the intestine, therefore increasing fat oxidation.…”

“…In a meta-analysis of 30 studies with 14,401 participants, the Thr54/Thr54 genotype was strongly associated with increased TC and LDL-C levels, as well as decreased HDL-C levels [ 16 ]. Khattab et al, (2017) confirmed that carriers of the Thr54/Thr54 genotype had decreased HDL-C concentrations [ 24 ]. Conversely, some studies have reported that lipid profiles do not significantly differ based on FABP2 genotype [ 27 , 28 ].…”

Alternating consumption of β‐glucan and quercetin reduces mortality in mice with colorectal cancer

“…HMGCS2 can also increase the heterotopic expression of cancer cells to enhance the vitality of cancer cells (Chen et al, ). Intestinal fatty acid binding protein 2 ( FABP2 ) is an intracellular protein, a highly specific marker of intestinal necrosis, expressed in intestinal epithelial cells and combined with saturated and unsaturated long‐chain fatty acids to participate in the absorption and transport of dietary fatty acids (Alharbi et al, ; Kano, Takahashi, Inoue, Tanaka, & Okita, ; Khattab, Abo‐Elmatty, Ghattas, Mesbah, & Mehanna, ). Gpt is a marker of hepatocyte injury, which is higher in patients with hepatitis than in healthy people (Sosa, Vidlak, Strachota, Pavlik, & Jerrells, ).…”

“…Some studies have shown that HMGCS2 may relate to the progression of cancer and play a key role in enhancing the phenotype of tumor migration, invasion, and metastasis through an independent metabolic mechanism in vitro. HMGCS2 can also increase the heterotopic expression of cancer cells to enhance the vitality of cancer cells (Chen et al, 2017).…”