Intestinal microbiomics and liver metabolomics insights into the preventive effects of chromium (III)-enriched yeast on hyperlipidemia and hyperglycemia induced by high-fat and high-fructose diet

Dietary succinate reduces fat deposition through gut microbiota and lipid metabolism in broilers

“…It can be assumed that succinate regulates lipid metabolism in broiler chickens by lowering their F/B ratio. We found that the growth of Lactobacillus in the cecum at the genus level was stimulated by succinate in the diet, similar to previous results ( Wang, et al, 2022a ). Lactobacillus is commonly used as a probiotic, with increased levels of bacteria promoting SCFAs production in the cecum.…”

Association between blood chromium and hepatic steatosis assessed by liver ultrasound transient elastography: National Health and Nutrition Examination Survey 2017–2020

“…Cr supplementation inhibits the activities of α-amylase and α-glucosidase, exerting a beneficial effect on postprandial blood glucose ( 28 , 29 ). In animal models of metabolic syndrome and T2DM, Cr supplementation inhibited hepatic gluconeogenesis by decreasing mRNA expression of fructose 1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase (G6Pase) and promoted hepatic glycogen synthesis by upregulating glucokinase (Gk) mRNA expression in the liver ( 32 – 34 ). In addition, Cr reduced the expression of CD36 in liver tissue and SMMC-7721 cells, thus decreasing the uptake of exogenous fatty acids, while increasing the levels of liver type fatty acid binding protein (L-FABP) mRNA in liver tissue, promoting fatty acid transport across cell membranes and into mitochondria, which enhanced hepatic fatty acid utilization ( 8 , 33 – 36 ).…”

“…Furthermore, Cr enhances cholesterol metabolism. In Kunming mice with metabolic syndrome, Cr supplementation promoted cholesterol transport and metabolism by upregulating the mRNA expression of apolipoprotein E (ApoE) and low-density lipoprotein receptor (LDLR) and suppressed cholesterol synthesis by upregulating cytochrome P450 7A1 (CYP7A1) mRNA expression ( 32 , 33 ). Finally, recent studies suggest that Cr supplementation significantly alteres the gut microbiome in animal models of T2DM and metabolic syndrome, leading to the improvement of glucose and lipid metabolism and the inhibition of liver lipid accumulation by the “gut-liver axis” ( 32 – 34 ).…”

Effects of the composition of food and medicine homologous ingredients complex supplementation on lipid metabolism and gut microbiota diversity in high‐fat diet‐induced obese mice

“…The main manifestation of fat metabolism in obesity is a general increase in blood lipid components such as TG, TC, LDL‐C, AST and ALT. Persistent hyperlipidaemia is positively correlated with abnormal lipid accumulation in the liver, ultimately leading to obesity (Wang et al ., 2022). In this study, HFD + M and HFD + H interventions significantly improved serum and liver lipid levels, liver tissue morphology and liver lipid droplet count in obese mice ( P < 0.001) (Figs 2 and 3).…”