Intestinal Microbiota Is Altered in Patients with Gastric Cancer from Shanxi Province, China

Qi, Yufeng; Sun, Junning; Ren, Laifeng; Cao, Xue-Ling; Dong, Jingcheng; Tao, Kai; Guan, Xuemei; Cui, Ya-Ni; Su, Wen Pang

doi:10.1007/s10620-018-5411-y

Cited by 62 publications

(44 citation statements)

References 32 publications

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“…Moreover, butyrate is a cooperative product of many symbiotic bacteria in the intestine. Many studies have confirmed that there was a variety of symbiotic bacteria in the intestine that can produce butyrate directly [34][35][36] . A small number of bacteria promote the growth of specific bacteria to increase the production of butyrate.…”

Section: Discussionmentioning

confidence: 99%

Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients

et al. 2021

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Accumulating evidence has shown many similarities and differences of gene profiles and pathways between pediatric and adult ulcerative colitis (UC) patients. In this study, we aimed to investigate the shared genes and pathways in intestinal tissues of pediatric and adult UC. Differentially expressed genes (DEGs) between pediatric and adult UC were identified via bioinformatic analysis of Gene Expression Omnibus datasets GSE87473 and GSE126124. Gene Ontology and pathway enrichment were used to analyze overlapped and distinguished DEGs. Gene Set Variation Analysis (GSVA) was utilized for contrast consistency. Mice colitis models were induced by dextran sulfate sodium (DSS) and Citrobacter rodentium. 2616 DEGs were screened out in intestinal tissues of adult UC compared with those of adult healthy controls, and 1195 DEGs in pediatrics.Same pathways between pediatric and adult UC were enriched using overlapped DEGs, mainly related to immune responses and metabolic processes, including butyrate metabolism, which was also identified by GSVA analysis. Of note, butyrate metabolism was the exclusive down-regulated pathway enriched by these two analyses, indicating that butyrate metabolism is one of the key pathways associated with both pediatric and adult UC. In addition, butyrate suppressed DSS-induced and Citrobacter rodentium-induced intestinal inflammation in mice. Therefore, the study revealed that butyrate metabolism was critical in both pediatric and adult UC. And butyrate suppressed colitis in mice, which provided a theoretical basis for the potential treatment of butyrate for UC patients.

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Section: Discussionmentioning

confidence: 99%

Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients

et al. 2021

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“…Fifty studies linked differences in the gut microbiome with colorectal cancer, three with breast cancer risk (79-81) and two with gastric cancer risk (82,83). Thirty-three articles used fecal samples as a proxy for the gut microbiome, while 22 articles used mucosal biopsies.…”

Section: Overall Significant Findingsmentioning

confidence: 99%

The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies

Huybrechts

Zouiouich

Loobuyck

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The microbiome has been hypothesized to play a role in cancer development. Because of the diversity of published data, an overview of available epidemiologic evidence linking the microbiome with cancer is now needed. We conducted a systematic review using a tailored search strategy in Medline and EMBASE databases to identify and summarize the current epidemiologic literature on the relationship between the microbiome and different cancer outcomes published until December 2019. We identified 124 eligible articles. The large diversity of parameters used to describe microbial composition made it impossible to harmonize the different studies in a way that would allow metaanalysis, therefore only a qualitative description of results could be performed. Fifty studies reported differences in the gut microbiome between patients with colorectal cancer and various control groups. The most consistent findings were for Fusobacterium, Porphyromonas, and Peptostreptococcus being significantly enriched in fecal and mucosal samples from patients with colorectal cancer. For the oral microbiome, significantly increased and decreased abundance was reported for Fusobacterium and Streptococcus, respectively, in patients with oral cancer compared with controls. Overall, although there was a large amount of evidence for some of these alterations, most require validation in high-quality, preferably prospective, epidemiologic studies.

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“…Related research is relatively scarce. A study from Shanxi Province, China, disclosed the bacteria community alteration in fecal may be associated with GC [ 13 ]. Our previous study showed that the lifestyle contributed greatly to the GC risk and gender difference [ 14 ], since diet and lifestyle were the pivotal factors in shaping the gut microbes.…”

Section: Introductionmentioning

confidence: 99%

Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer

Zhang

et al. 2020

Disease Markers

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Although intestinal microbial dysbiosis was confirmed to be associated with many chronic diseases and health status through complicated interaction with the host, the effect on gastric cancer was less studied. In this study, we sequenced the 16S rRNA and 18S rRNA genes of fecal bacteria and fungi, respectively, in 134 gastric cancer patients and 58 healthy controls matched by age and gender. Propensity score matching (PSM) was adopted for adjusting diet habits and lifestyle, and 44 patients and 44 healthy controls (matching population) were enrolled. Serum antibody to H. pylori and metabolites of the matching population were detected. The positive rates of antibody to H. pylori between the patients and the control group did not reach the statistical difference. LEfSe analysis indicated that bacteria were more stable than fungi when adjusting diet and lifestyle. Veillonella, Megasphaera, and Prevotella 7 genus and Streptococcus salivarius subsp. Salivarius, Bifidobacterium dentium, and Lactobacillus salivarius species in bacteria were related to the risk of gastric cancer and showed a good diagnostic value in distinguishing the patients from healthy controls. Streptococcus mitis showed a risk effect for gastric cancer; however, the effect turned into be protective after PSM. Serum L-alanine, L-threonine, and methionol were positively associated with Veillonella and Streptococcus and several fungi genus. Overall, our findings indicated that fecal microbiome constitution alteration may be associated with gastric cancer through influencing the amino acid metabolism.

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Intestinal Microbiota Is Altered in Patients with Gastric Cancer from Shanxi Province, China

Cited by 62 publications

References 32 publications

Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients

Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients

The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies

Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer

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