Intestinal Mucosal Characteristic Flora in Diarrhea with Intestinal Dampness-Heat Syndrome

Abstract

Background With the change of lifestyle and diet structure in our daily life, diarrhea with intestinal dampness-heat syndrome (IDHS) has become a multiple disease. Emerging evidence indicates that intestinal flora contributes to the occurrence and development of diarrhea. However, little is known about the effects of the intestinal mucosal characteristic flora and specific mechanism on diarrhea with IDHS. To evaluate the characteristic biomarkers role of intestinal mucosal flora in diarrhea with IDHS. Results Our study manifested that diarrhea with IDHS had the modulated effect on the diversity of intestinal mucosal flora, presented by the increasing Chao 1 and Observed species indexes and decreasing Simpson and Shannon indexes in the model group. The apparent dispersion between the control and model group indicated that diarrhea with IDHS altered the overall structure of the intestinal mucosal flora. The composition of the dominant bacteria was basically similar both at the phylum level and genus level before and after modelling, while the modeling led to change in the relative abundance of dominant bacteria at the species level, specially reflected in a significant decrease in the abundance of Lactobacillus gasseri and Lactobacillus salivarius in the model group. Conclusions To sum up, Lactobacillus gasseri and Lactobacillus salivarius could serve as potential biomarkers for diarrhea with IDHS of the intestinal mucosal flora in mice and the mechanism of diarrhea with IDHS might be attributed to the inhibition of the growth of Lactobacillus gasseri and Lactobacillus salivarius.