Intestinal Secretion: Stimulation by Peptides

Barbezat, G. O.; Grossman, Morton I.

doi:10.1126/science.174.4007.422

Cited by 267 publications

(73 citation statements)

References 13 publications

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“…In many cases, where hormones or other agents influence the electrolyte transport in this tissue, increased intracellular cyclic AMP levels have been associated with decreased absorption (21)(22)(23)(24)(25)(26)(27)(28). Therefore, it was of interest to measure the cyclic AMP levels for diabetic mucosa and compare them with normal levels.…”

Section: Cyclic Amp Levels In Diabetesmentioning

confidence: 99%

Diabetes mellitus: changes in the transport properties of isolated intestinal microvillous membranes.

Hopfer¹

1975

Proc. Natl. Acad. Sci. U.S.A.

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Isolated, small intestinal microvillous membranes from normal and acutely diabetic rats were compared with respect to D-glucose transport. D-Glucose was accumulated to a greater extent by diabetic membrane vesicles when supplied with energy in the form of a NaCl or a NaSCN gradient across the vesicle membrane. The difference appeared to be caused by an ability of the diabetic membranes to maintain a higher driving force for active D-glucose transport and not by changes in the glucose "carrier." Increasing the glucose-independent Na+_conductance of the membrane with monactin or gramicidin D reduced the active accumulation of D-glucose by membrane preparations from both control and diabetic groups. Concentrations of monactin and gramicidin D in the incubation medium of membrane vesicles from diabetic animals could be adjusted so that their D-glucose transport became indistinguishable from that of membranes from normal animals not treated with ionophores.

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Section: Cyclic Amp Levels In Diabetesmentioning

confidence: 99%

Diabetes mellitus: changes in the transport properties of isolated intestinal microvillous membranes.

Hopfer¹

1975

Proc. Natl. Acad. Sci. U.S.A.

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“…Vasoactive intestinal polypeptide (VIP), a hormone that is chemically related to glucagon and secretin (Said & Mutt, 1972), increases gut secretion (Barbezat & Grossman, 1971) and has been implicated as the diarrhoeal agent in certain disease states (Bloom, Polak & Pearse, 1973; Seif, Sadowski, Heni, Fischer, Bloom, & Polak, 1975). Glucagon has previously been shown to decrease absorption by the canine gut, at least partly.…”

Section: Introductionmentioning

confidence: 99%

Effects of vasoactive intestinal polypeptide on intestinal absorption and blood flow.

Mailman¹

1978

The Journal of Physiology

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SUMMARY1. Intestinal absorption and blood flow in anaesthetized dogs was determined after i.v. infusion of vasoactive intestinal polypeptide (VIP) (1-75-175 ng/min) to determine the contribution of the cardiovascular changes to transport.2. 22Na and 3H20 were utilized to determine the unidirectional fluxes of Na and H20 from saline perfused through the ileal lumen and the clearances of 3H20 were used to determine total and absorptive site blood flow.3. Net Na and H20 absorption were reversed to secretion by VIP at 175 ng/min due to a significant decrease in unidirectional absorptive fluxes and smaller increases in secretary fluxes.4. Arterial pressure and absorptive site blood flow were reduced in proportion to the changes in Na and H20 fluxes.5. Total and absorptive site blood flow decreased and the blood flow resistances increased.6. Prior treatment with guanethidine to suppress sympathetic effects did not greatly affect the responses to VIP. Prior treatment with atropine to suppress cholinergic effects inhibited most of the effects of VIP.7. Absorptive site blood flow was linearly related to absorptive fluxes of Na and H20 but with different slopes for results from atropinized dogs as compared to those from dogs given VIP alone or VIP plus guanethidine.8. It was concluded that VIP reduces gut absorption through a generalized cardiovascular effect and also through a mechanism which depends on the release of ACh by the gut.

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“…Vasoactive intestinal polypeptide (VIP), first isolated from the porcine small intestine (21), has a diverse biological activity not only in secretory processes such as inhibition of gastric acid secretion (15), stimulation of small intestine (2), and colonic ion transport. (17), but also in cardiovascular and respiratory systems (20).…”

mentioning

confidence: 99%

<b>RECEPTORS FOR VASOACTIVE INTESTINAL POLYPEPTIDE ON RAT DISPERSED PINEAL </b><b>CELLS </b>

et al. 1983

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The receptor for vasoactive intestinal polypeptide (VIP) was characterized using rat dispersed pineal cells. 1251-VIP binding to the cells was saturable, reversible, and temperature-dependent. Scatchard analysis of "SI-VIP binding indicated the presence of two classes of binding sites: a. high aflinity-low capacity site and a low affinityhigh capacity site. Each cell possessed 42,000 high aflinity binding sites with a dissociation constant (Kd) of 0.8 >< l0'9M, and 780,000 low afiinity binding sites with a K, of 32>< l0"9M, respectively. Norepinephrine did not inhibit 1251-VIP binding to the pineal cells. 1251-VIP binding was displaced by natural secretin with 1/ l00 the potency of unlabeled VIP. The potency of displacement of C-terminal and Nterminal fragments was lower than that of natural secretin. VIP stimulated cyclic AMP production of the pineal cells with dose-dependency. Half-maximal stimulation was detected at a concentration of l0'9M. This stimulatory efiect closely corresponded with the manner of binding by VIP to the pineal cells. These results clearly demonstrate that the functions of the pineal gland are regulated through a. dual (,8-adrenergic and VIPergic) control system.

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Intestinal Secretion: Stimulation by Peptides

Cited by 267 publications

References 13 publications

Diabetes mellitus: changes in the transport properties of isolated intestinal microvillous membranes.

Diabetes mellitus: changes in the transport properties of isolated intestinal microvillous membranes.

Effects of vasoactive intestinal polypeptide on intestinal absorption and blood flow.

<b>RECEPTORS FOR VASOACTIVE INTESTINAL POLYPEPTIDE ON RAT DISPERSED PINEAL </b><b>CELLS </b>

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