Intestinal staphylococcal small colony variants: a cause of medically unexplained physical symptoms?

Berstad, Arnold; Hauso, Olav; Valeur, Jørgen

doi:10.3402/mehd.v25.25817

Microbial Ecology in Health & Disease

2014

DOI: 10.3402/mehd.v25.25817

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Intestinal staphylococcal small colony variants: a cause of medically unexplained physical symptoms?

Arnold Berstad¹,

Olav Hauso²,

Jørgen Valeur³

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2016

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Cited by 2 publications

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“…If the abundance of lactic acid bacteria for some reasons is declining, their protective function will inevitably be reduced, and epithelial tissues become more prone to staphylococcal infection and to overgrowth of Candida albicans ( 2 ). We envisage that something similar is taking place in the intestines of irritable bowel syndrome (IBS) patients ( 3 ).…”

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confidence: 99%

Probiotic lactic acid bacteria – the fledgling cuckoos of the gut?

Berstad¹,

Raa²,

Midtvedt³

et al. 2016

Microbial Ecology in Health & Disease

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It is tempting to look at bacteria from our human egocentric point of view and label them as either ‘good’ or ‘bad’. However, a microbial society has its own system of government – ‘microcracy’ – and its own rules of play. Lactic acid bacteria are often referred to as representatives of the good ones, and there is little doubt that those belonging to the normal intestinal flora are beneficial for human health. But we should stop thinking of lactic acid bacteria as always being ‘friendly’ – they may instead behave like fledgling cuckoos.

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mentioning

confidence: 99%

Probiotic lactic acid bacteria – the fledgling cuckoos of the gut?

Berstad¹,

Raa²,

Midtvedt³

et al. 2016

Microbial Ecology in Health & Disease

Self Cite

View full text Add to dashboard Cite

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Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections

2016

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SUMMARYSmall colony variants (SCVs) were first described more than 100 years ago forStaphylococcus aureusand various coagulase-negative staphylococci. Two decades ago, an association between chronic staphylococcal infections and the presence of SCVs was observed. Since then, many clinical studies and observations have been published which tie recurrent, persistent staphylococcal infections, including device-associated infections, bone and tissue infections, and airway infections of cystic fibrosis patients, to this special phenotype. By their intracellular lifestyle, SCVs exhibit so-called phenotypic (or functional) resistance beyond the classical resistance mechanisms, and they can often be retrieved from therapy-refractory courses of infection. In this review, the various clinical infections where SCVs can be expected and isolated, diagnostic procedures for optimized species confirmation, and the pathogenesis of SCVs, including defined underlying molecular mechanisms and the phenotype switch phenomenon, are presented. Moreover, relevant animal models and suggested treatment regimens, as well as the requirements for future research areas, are highlighted.

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Intestinal staphylococcal small colony variants: a cause of medically unexplained physical symptoms?

Cited by 2 publications

References 6 publications

Probiotic lactic acid bacteria – the fledgling cuckoos of the gut?

Probiotic lactic acid bacteria – the fledgling cuckoos of the gut?

Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections

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