Intestinal-Type Adenocarcinoma of the Nasal Cavity and Paranasal Sinuses. A Clinicopathologic Study of 6 Cases

Abstract

The clinical and pathologic features of 6 cases of intestinal-type adenocarcinoma of the sinonasal region are presented. These cases were collected in a 17 year period (1972-1988) and account for less than 4% of malignancies of this region in our records for this period. All of the patients were men aged 48 to 82 years (mean, 54 years). Previous exposure to wood dust was reported in 1 case. Radiographic studies, especially computerized tomography, were of critical importance to delineate the extent of tumors. Nasal obstruction was the most common complaint. Duration of symptoms prior to diagnosis is available in 5 cases and ranged from 5 to 36 months (mean 18 months). Surgical treatment was performed in 4 patients (of palliative type in 2) followed by radiotherapy in 3. Histopathology revealed tubulo-papillary (5 cases) and mucinous (1 case) patterns. Follow-up is available in all patients (range 0 to 108 months), 50% of whom are still alive. In our series, only 1 patient has survived more than 5 years. Data pooled from the literature reveal that 53% of patients have experienced local recurrences following therapy, and 60% have died of their disease. Of these deaths, 80% occurred within 5 years of diagnosis.

Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance

“…We contend that subsequent genetic events, especially in the former, are most likely acquired during the progression as a result of locoregional and other epidemiological factors. [20][21][22][23][24][25][26][27] These results, along with the lack of any alteration in the seromucinous subtype, support a distinct pathway for the evolution and progression of the intestinal and primary colonic adenocarcinomas.…”

Paranasal sinus metastasis of breast cancer

“…Symptoms from metastatic involvement of the paranasal sinuses are usually vague and unspecific 3. Generally, patients present with facial pain, epistaxis, nasal swelling/obstruction2 – 5 and/or orbital symptoms such as proptosis, diplopia, decreased vision and ptosis 4 5. The pathogenesis of metastasis to the paranasal sinuses is unclear; neoplastic cells likely spread to the central nervous system and paranasal region through blood and lymphatic vessels.…”

Distant Metastases to Nasal Cavities and Paranasal Sinuses Case Series

“…It may be present with nasal or orbital symptoms. Nasal symptoms include epistaxis, nasal swelling, nasal obstruction and facial pain [4,5]. Orbital symptoms include proptosis, diplopia, decreased vision and ptosis [4,5].…”