Intoxicação experimental com as folhas de Jatropha gossypifolia (Euphorbiaceae) em ovinos

Oliveira, Laura Iglesias de; Jabour, Flávia Figueiraújo; Nogueira, Vivian A.; Yamasaki, Elise M.

doi:10.1590/s0100-736x2008000600003

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…The study of experimental poisoning in sheep showed that the intake of fresh plant leaves in a single dose of 40 g/kg was lethal to these animals [ 137 ]. The clinical and pathological picture in the experimental sheep was characterized by digestive, lung, and heart disturbances and also by slight regressive changes evidenced in hepatic and renal histological examinations [ 137 ].…”

Section: Toxicologymentioning

confidence: 99%

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

Félix-Silva

Giordani

Silva-Jr

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Jatropha gossypiifolia L. (Euphorbiaceae), widely known as “bellyache bush,” is a medicinal plant largely used throughout Africa and America. Several human and veterinary uses in traditional medicine are described for different parts and preparations based on this plant. However, critical reviews discussing emphatically its medicinal value are missing. This review aims to provide an up-to-date overview of the traditional uses, as well as the phytochemistry, pharmacology, and toxicity data of J. gossypiifolia species, in view of discussing its medicinal value and potential application in complementary and alternative medicine. Pharmacological studies have demonstrated significant action of different extracts and/or isolated compounds as antimicrobial, anti-inflammatory, antidiarrheal, antihypertensive, and anticancer agents, among others, supporting some of its popular uses. No clinical trial has been detected to date. Further studies are necessary to assay important folk uses, as well as to find new bioactive molecules with pharmacological relevance based on the popular claims. Toxicological studies associated with phytochemical analysis are important to understand the eventual toxic effects that could reduce its medicinal value. The present review provides insights for future research aiming for both ethnopharmacological validation of its popular use and its exploration as a new source of herbal drugs and/or bioactive natural products.

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Section: Toxicologymentioning

confidence: 99%

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

Félix-Silva

Giordani

Silva-Jr

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Na dose de 40g/ Kg todos os ovinos submetidos ao ensaio morreram, sendo os sintomas princiais diminuição do apetite até anorexia, fezes pastosas até líquidas, respiração dispnéica, taquicardia, apatia, decúbito e morte (OLIVEIRA, et al, 2008).…”

Section: Jatropha Gossypifoliaunclassified

FITOQUÍMICA E ATIVIDADES BIOLÓGICAS DO GÊNERO Jatropha: MINI-REVISÃO

Hirota¹,

Trevisan²,

Dias³

et al. 2010

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“…However, there are records of the use of Jatropha curcas as purgative by humans and animals causing intoxication (OLIVEIRA et al, 2008). The limitation of the use of this co-product as food is attributed to the presence of toxic, allergenic and anti-nutritional components (ABDALLA et al , 2008;MENDONÇA, 2010) such as curcina, diterpene esters (phorbol ester) and proteins with allergenic potential (OLIVEIRA; AKISUE, 2005).…”

Section: Introductionmentioning

confidence: 99%

Torta de pinhão-manso (Jatropha curcas): implicações hepatotóxicas

Honorato

Silva

Flores-Quintana

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

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Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation into animal diets. The objective of this study was to evaluate the hepatotoxicity of diets added with jatropha cake -JC (Jatropha curcas) in rats. Thirty-five (35) male Wistar adults rats (Rattus norvegicus) with initial weight of 352.1 ± 26.8 g were used. The animals were fed for 21 days with the diets: control, 10, 25, 40 and 50% JC. In the feeding with 50% JC the animals presented themselves prostrate and with piloerection. Development and survival decreased, since the inclusion of JC in diets increased. In rats submitted to 10 and 25% JC there was an increase of 17.52% in the hepatosomatic index in relation to the control group. Increase of JC in the rat diet promoted an increase in the activity of ALT and AST enzymes. Anatomic-histopathological evaluation demonstrated that, regardless of the levels tested, JC in rat diet causes hypertrophy of the hepatocytes, with a reduction in energy reserves. This study demonstrated that the use of JC resulted in decreased food intake, associated with weight loss due to the clinical pattern of toxicity, demonstrated by biochemical and histopathological changes in the liver. It was concluded that the inclusion of jatropha cake in rat feeding presents high hepatotoxic potential leading to lesions in the liver parenchyma. Keywords: Toxic. The hepatotoxicity. Animal feed. ResumoO pinhão-manso tem se destacado como oleaginosa potencial para a produção de biocombustível. A torta, coproduto da extração do óleo, poderia ser utilizada na alimentação animal. No entanto, algumas variedades de pinhão-manso são tóxicas, limitando sua incorporação em dietas animais. Objetivou-se neste estudo avaliar a hepatotoxicidade de dietas acrescidas de torta de pinhão-manso (Jatropha curcas) em ratos. Foram utilizados trinta e cinco (35) ratos Wistar (Rattus norvergicus) machos adultos com peso inicial de 352,1 ± 26,8 g. Os animais foram alimentados por 21 dias com as dietas: controle, 10, 25, 40 e 50% TPM. Na alimentação com 50% TPM os animais apresentaram-se prostrados e com piloereção. O desenvolvimento e a sobrevivência apresentaram diminuição conforme o aumento da inclusão de TPM nas dietas. Em ratos submetidos a 10 e 25% TPM houve aumento de 17,52% no índice hepatossomático em relação ao grupo controle. O aumento de TPM na dieta de ratos promoveu aumento da atividade das enzimas ALT e AST. A avaliação anatomo-histopatológica revelou que, independentemente dos níveis testados, a TPM na alimentação de ratos provoca hipertrofia dos hepatócitos, com redução das reservas energéticas. Este estudo demonstrou que a utilização de TPM resultou em diminuição do consumo de alimento associado à perda de peso devido ao quadro clínico de toxicidade demonstrado pelas alterações bioquímica e histopatológica no fígado. Conclui-se que a inclusão de torta de pinhão-manso ...

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Intoxicação experimental com as folhas de Jatropha gossypifolia (Euphorbiaceae) em ovinos

Cited by 10 publications

References 7 publications

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

FITOQUÍMICA E ATIVIDADES BIOLÓGICAS DO GÊNERO Jatropha: MINI-REVISÃO

Torta de pinhão-manso (Jatropha curcas): implicações hepatotóxicas

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