Intra‐ and inter‐individual variability in the mechanical properties of the human skin from in vivo measurements on 20 volunteers

Jacquet, Emmanuelle; Chambert, Jérôme; Pauchot, J.; Sandoz, Patrick

doi:10.1111/srt.12361

Cited by 30 publications

(20 citation statements)

References 30 publications

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“…Several skin models have been established for determining the penetration kinetics of drugs into the skin [40]. Due to intra-and inter-individual variability of the skin models, only limited standardized data are available [40,41]. In chronic inflammatory skin diseases, such as atopic dermatitis, the barrier function of the skin is disturbed and thus weakened [42].…”

Section: Discussionmentioning

confidence: 99%

Nanocrystals for Improved Drug Delivery of Dexamethasone in Skin Investigated by EPR Spectroscopy

et al. 2020

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Nanocrystals represent an improvement over the traditional nanocarriers for dermal application, providing the advantages of 100% drug loading, a large surface area, increased adhesion, and the potential for hair follicle targeting. To investigate their advantage for drug delivery, compared to a base cream formulation, dexamethasone (Dx), a synthetic glucocorticoid frequently used for the treatment of inflammatory skin diseases, was covalently linked with the paramagnetic probe 3-(carboxy)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (PCA) to DxPCA. To investigate the penetration efficiency between these two vehicles, electron paramagnetic resonance (EPR) spectroscopy was used, which allows the quantification of a spin-labeled drug in different skin layers and the monitoring of the drug release. The penetration behavior in excised healthy and barrier-disrupted porcine skin was monitored by EPR, and subsequently analyzed using a numerical diffusion model. As a result, diffusion constants and free energy values in the different layers of the skin were identified for both formulations. Dx-nanocrystals showed a significantly increased drug amount that penetrated into viable epidermis and dermis of intact (factor 3) and barrier-disrupted skin (factor 2.1) compared to the base cream formulation. Furthermore, the observed fast delivery of the spin-labeled drug into the skin (80% DxPCA within 30 min) and a successive release from the aggregate unit into the viable tissue makes these nanocrystals very attractive for clinical applications.

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Section: Discussionmentioning

confidence: 99%

Nanocrystals for Improved Drug Delivery of Dexamethasone in Skin Investigated by EPR Spectroscopy

et al. 2020

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“…Previous studies on the biomechanical properties of skin materials revealed that mechanical behavior was closely related to the collagen network of skin [21]. Jacquet et al [22] achieved skin stress-strain curves under di erent conditions by conducting uniaxial tensile tests on volunteers with di erent anatomical locations and di erent directions. Karimi et al [23] obtained the prelinear viscoelastic properties of rat back and abdominal skin under uniaxial loading.…”

Section: Finite Element Analysis Of the V-y Flapmentioning

confidence: 99%

Preoperative Evaluation of V-Y Flap Design Based on Computer-Aided Analysis

Yang

Peng

Yang

et al. 2020

Computational and Mathematical Methods in Medicine

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V-Y flap is widely used in plastic surgery as an important technique for reconstructing deformities and improving appearance. In this paper, a geometrical parameter model and finite element analysis were used to study the rationale of the proposed V-Y flap design and the preoperative evaluation of the V-Y flap design. First, a geometric parameter model of the V-Y flap was established to analyze the five key geometric relationships affecting the flap structure and obtain a reasonable plan for the V-Y flap design through the crossing constraint relationship. Second, in order to verify the effectiveness of the V-Y flap design, the suture and release states of the V-Y flap during surgery were evaluated based on a simulation model of the V-Y flap generated by finite element analysis software. The results revealed that the approach proposed in this paper provides a feasible method for clinical V-Y flap design.

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“…As in Jacquet et al (2017a), three physical parameters are identified from the stress-strain curve using a non-linear least squares method:…”

Section: Extensometrymentioning

confidence: 99%

“…One possibility consists in studying keloids by means of measurement devices dedicated to in vivo skin (de Rigal, 2002;Boyer et al, 2013;Dobrev, 2014;Jacquet et al, 2017b). These devices address in different ways the complexity tied to the skin properties -anisotropic viscous, hyperelastic and prestressed tissue (Xu et al, 2008) -and to the variability of the skin as a function of the body site, the age and the posture of individuals (Flynn et al, 2011;Jacquet et al, 2017a). Krusche and Worret (1995) have carried out suction tests on keloids at a macroscopic scale in order to evaluate an antikeloidal treatment.…”

Section: Introductionmentioning

confidence: 99%

Multimodal investigation of a keloid scar by combining mechanical tests in vivo with diverse imaging techniques

Chambert

Lihoreau

Joly

et al. 2019

Journal of the Mechanical Behavior of Biomedical Materials

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Keloids are pathologic scars, defined as fibroproliferative diseases resulting from abnormal wound responses, which grow beyond the original wound margins. They develop on specific pro-keloid anatomic sites frequently characterized by high stress states. The initiation and growth mechanisms of keloid are not well-understood. This study relates multimodal investigation of a keloid by using mechanical tests in vivo and imaging techniques. A single case composed of a keloid, the healthy skin surrounding the keloid, and the contralateral healthy skin on the upper arms of a woman has been investigated in extension and suction by using non-invasive devices dedicated to in vivo skin measurement. The thickness and microstructure of these soft tissues have been observed by echography, tomography and confocal microscopy. Displacement fields 1 have been obtained by using digital image correlation. Unlike healthy skin, keloid is not a well-defined multilayer structure: the frontier between epidermis and dermis disappears. The mechanical behavior of keloid is highly different from healthy skin one. The R-parameters have been deduced from suction curves. Physical parameters as tissue extensibility, initial and final tangent moduli have been identified from the stress-strain curves. The extensibility (respectively, initial rigidity) of keloid is highly lower (respectively, higher) than that of healthy skin. To compare the final rigidity of keloid versus healthy skin, further tests have to be performed with higher strain values.

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Intra‐ and inter‐individual variability in the mechanical properties of the human skin from in vivo measurements on 20 volunteers

Cited by 30 publications

References 30 publications

Nanocrystals for Improved Drug Delivery of Dexamethasone in Skin Investigated by EPR Spectroscopy

Nanocrystals for Improved Drug Delivery of Dexamethasone in Skin Investigated by EPR Spectroscopy

Preoperative Evaluation of V-Y Flap Design Based on Computer-Aided Analysis

Multimodal investigation of a keloid scar by combining mechanical tests in vivo with diverse imaging techniques

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