Relevance. Surgical interventions used in cardiovascular surgery often lead to the development of many different etiology and manifestations of purulent-septic complications. The development of this pathology worsens the course of the postoperative period and increases the duration of the patient's stay in the hospital. The range of these complications varies quite widely, which is explained by the different initial state of the patient's body, as well as the peculiarities of operations, care and treatment in the postoperative period.The purpose of this study is to study the frequency of occurrence of purulent-septic complications of mediastinal organs in surgery and to analyze the characteristics of this pathology.Materials and methods. In the course of this work, the analysis of foreign and domestic literature on the problem of the occurrence of purulent-septic complications of mediastinal organs in surgery was carried out.Results. The development of purulent-septic complications in cardiovascular surgery is due to a number of factors, among which it is necessary to note the presence of concomitant diseases, the peculiarities of some surgical interventions, inadequate antibacterial therapy. Due to the severity of the above factors, the development of many formidable purulent-septic diseases is possible. And unfortunately, even with timely treatment of the patient, the percentage of mortality from them remains quite high.Conclusion. Purulent-septic complications in cardiac surgery practice are a frequent phenomenon associated with a variety of risk factors. Such complications include mediastinitis, sepsis, pneumonia, urinary tract infections, local inflammatory reactions and much more. However, thanks to the knowledge of the causes of their occurrence and the features of the clinical course, it is possible to choose appropriate methods for correcting a particular condition at various stages of the patient's treatment.