Intra-coronary thrombus evolution during acute coronary syndrome: regression assessment by serial optical coherence tomography analyses

Amabile, Nicolas; Hammas, Sami; Veugeois, Aurélie; Caussin, Christophe

doi:10.1093/eurheartj/eht309.p3949

Cited by 5 publications

(8 citation statements)

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“…1 Although virtual histology-IVUS imaging may color an intracoronary thrombus, 2 we did not perform this procedure because it might not visualize areas lying behind microcalcifications due to acoustic shadowing. Because OFDI can detect a thrombus clearly, 3 we performed OFDI, which revealed a mass with attenuation, behind the calcification, which was suspected to be a red thrombus. There were no erosions noted from plaque rupture, but a red thrombus could have caused acute coronary syndrome.…”

Section: Discussionmentioning

confidence: 99%

A case with a large intracoronary mobile mass diagnosed with a calcified thrombus using optical frequency domain imaging and intravascular ultrasound

Kuno

Hashimoto

Imaeda

et al. 2017

SAGE Open Medical Case Reports

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Objectives:A calcified thrombus is rare, but needs to be recognized and to be differentiated from calcified nodule.Methods:We report a case of acute coronary syndrome and a large intracoronary mobile mass, which was identified as a calcified thrombus by optical frequency domain imaging and intravascular ultrasound.Results:Successful direct stenting indicated that mobile mass was a calcified thrombus, not a calcified nodule.Conclusions:Cardiologists should be aware that an intracoronary mobile mass could be a calcified thrombus. This diagnosis can be confirmed through the combined use of optical frequency domain imaging and intravascular ultrasound.

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Section: Discussionmentioning

confidence: 99%

A case with a large intracoronary mobile mass diagnosed with a calcified thrombus using optical frequency domain imaging and intravascular ultrasound

Kuno

Hashimoto

Imaeda

et al. 2017

SAGE Open Medical Case Reports

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“…To evaluate IST, we used two methods, IST score and maximum IST. The IST score was used as a semi-quantitative method to measure global IST throughout the stent [3,5,14,27,28]. This parameter has been reported to highly correlate with actual IST volume [3,5,14,27].…”

Section: [ ( F I G _ 3 ) T D $ F I G ]mentioning

confidence: 99%

“…The IST score was used as a semi-quantitative method to measure global IST throughout the stent [3,5,14,27,28]. This parameter has been reported to highly correlate with actual IST volume [3,5,14,27]. Kajander et al investigated feasibility and repeatability of volumetric stent thrombus measurements by OCT and reported that IST score has been highly correlated to actual thrombus volume (r = 0.95) [27].…”

Section: [ ( F I G _ 3 ) T D $ F I G ]mentioning

confidence: 99%

“…In [ ( F i g . _ 4 ) T D $ F I G ] fact, this relatively simple parameter was introduced as the method to measure thrombus volume by the expert review document of methodology, terminology, and clinical applications of OCT for the assessment of interventional procedures in the European Heart Journal [14], which has been also used as the primary endpoint volume [28] and the secondary endpoint of the study to evaluate thrombus volume [3,5]. To eliminate the impact of stent length, we evaluated averaged IST score.…”

Section: [ ( F I G _ 3 ) T D $ F I G ]mentioning

confidence: 99%

“…Optical coherence tomography (OCT) clearly visualizes atherothrombotic burden before and after primary PCI in ACS patients [3,4], and potentially enables us to monitor acute phase changes of intra-stent tissue (IST) including thrombus and plaque protrusion following initial treatment [5].…”

Section: Introductionmentioning

confidence: 99%

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Potent effect of prasugrel on acute phase resolution of intra-stent athero-thrombotic burden after percutaneous intervention to acute coronary syndrome

Tsukiyama

Kozuki

Shinke

et al. 2018

Journal of Cardiology

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Early Vascular Response to Ultrathin Biodegradable Polymer Sirolimus-Eluting Stents for the Treatment of ST-Elevation Myocardial Infarction After Plaque Rupture

et al. 2021

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Recent clinical studies suggest that newer-generation drug-eluting stents that combine ultrathin struts and nanocoating (biodegradable polymer sirolimus-eluting stents, BP-SES) could improve long-term clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). However, the early vascular response to BP-SES in these patients has not been investigated so far.We examined this response in 20 patients with STEMI caused by plaque rupture using frequency-domain optical coherence tomography (OCT) to understand the underlying mechanisms. Plaque rupture was diagnosed by OCT before PCI with BP-SES implantation was performed. OCT was again performed before the final angiography (post-PCI) and after 2 weeks (2W-OCT).BP-SES placement caused protrusion of atherothrombotic material into the stent lumen and incomplete stent apposition in all patients. After 2 weeks, incomplete stent apposition was significantly reduced (% malapposed struts: post-PCI 4.7 ± 3.3%; 2W-OCT 0.9 ± 1.2%; P < 0.0001), and the percentage of uncovered struts also significantly decreased (% uncovered struts: post-PCI; 69.8 ± 18.3%: 2W-OCT; 29.6 ± 11.0%, P < 0.0001). The maximum protrusion area of the atherothrombotic burden was significantly reduced (post-PCI 1.36 ± 0.70 mm 2 ; 2W-OCT 0.98 ± 0.55 mm 2 ; P = 0.004).This study on the early vascular responses following BP-SES implantation showed rapid resolution of atherothrombotic material and progression of strut apposition and coverage.(UMIN000041324)

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Intra-coronary thrombus evolution during acute coronary syndrome: regression assessment by serial optical coherence tomography analyses

Cited by 5 publications

References 0 publications

A case with a large intracoronary mobile mass diagnosed with a calcified thrombus using optical frequency domain imaging and intravascular ultrasound

A case with a large intracoronary mobile mass diagnosed with a calcified thrombus using optical frequency domain imaging and intravascular ultrasound

Potent effect of prasugrel on acute phase resolution of intra-stent athero-thrombotic burden after percutaneous intervention to acute coronary syndrome

Early Vascular Response to Ultrathin Biodegradable Polymer Sirolimus-Eluting Stents for the Treatment of ST-Elevation Myocardial Infarction After Plaque Rupture

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