Intracellular Zn2+ Release Modulates Cardiac Ryanodine Receptor Function and Cellular Activity

Abstract

We recently developed and validated a novel mathematical model for Ca handling and ionic currents in human ventricular myocytes that is more robust than previous models in recapitulating relative contributions of various repolarizing K currents, and in describing Ca cycling processes (Biophys J. 2009;96(3) S1:664a-665a). Here, we present intriguing results on some emergent proper-