Intracochleäre Medikamentenapplikation in Verbindung mit Cochleaimplantaten

Plontke, Stefan K.; Götze, G.; Rahne, Torsten; Liebau, Arne

doi:10.1007/s00106-016-0257-0

Cited by 5 publications

(4 citation statements)

References 62 publications

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“…Coating electrodes with dexamethasone significantly reduces the hearing loss caused by insertion trauma [135][136][137], limits fibrotic scars, and avoids electrical impedance increases [136,138]. In one pilot study, the safety of dexamethasone-eluting electrodes was demonstrated in a small patient group, and lower impedances were measured among the group of patients with dexamethasone-eluting cochlear implant electrodes [139].…”

Section: Future Directionsmentioning

confidence: 99%

Presbycusis: An Update on Cochlear Mechanisms and Therapies

Wang

Puel

2020

JCM

158

125

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Age-related hearing impairment (ARHI), also referred to as presbycusis, is the most common sensory impairment seen in the elderly. As our cochlea, the peripheral organ of hearing, ages, we tend to experience a decline in hearing and are at greater risk of cochlear sensory-neural cell degeneration and exacerbated age-related hearing impairments, e.g., gradual hearing loss, deterioration in speech comprehension (especially in noisy environments), difficulty in the localization sound sources, and ringing sensations in the ears. However, the aging process does not affect people uniformly; nor, in fact, does the aging process appear to be uniform even within an individual. Here, we outline recent research into chronological cochlear age in healthy people, and exacerbated hearing impairments during aging due to both extrinsic factors including noise and ototoxic medication, and intrinsic factors such as genetic predisposition, epigenetic factors, and aging. We review our current understanding of molecular pathways mediating ARHL and discuss recent discoveries in experimental hearing restoration and future prospects.

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Section: Future Directionsmentioning

confidence: 99%

Presbycusis: An Update on Cochlear Mechanisms and Therapies

Wang

Puel

2020

JCM

158

125

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“…Die rationale Grundlage für die Behandlung akuter cochleo-vestibulärer Störungen mit Kortikosteroiden ist aufgrund Ihrer Wirkung an den im Innenohr vorhandenen Glukokortikoid-und Mineralokortikoidrezeptoren gegeben [76]. Die protektive Wirkung von Kortikosteroiden konnte in Tiermodellen für verschiedene Traumata gezeigt werden: 1) akutes akustisches Trauma [77][78][79][80][81], 2) Aminoglykosidund Cisplatin-Ototoxizität [82,83], 3) Pneumokokken-Meningitis [84], 4) Autoimmunassoziierter Hörverlust [85,86], 5) Insertionstrauma bei CI-Implantation (Übersicht in: [87]).…”

Section: Kortikosteroideunclassified

“…Die Hauptindikationen betreffen die akute idiopathische sensorineurale Hörminderung ("Hörsturz"), Morbus Menière und Tinnitus. Aber auch weitere Indikationen sind im Fokus der präklinischen und klinischen Forschung [87,103].…”

Section: Lokale (Intratympanale) Therapieunclassified

Diagnostik und Therapie des Hörsturzes

Plontke

2017

Laryngo-Rhino-Otol

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This article reviews recent aspects of diagnostics, differential diagnostics and evidence in systemic and local therapy of idiopathic, sudden, sensorineural hearing loss (ISSHL). Since a number of disorders can be accompanied by sudden hearing loss a meaningful and targeted diagnostic strategy is of utmost importance. An important differential diagnosis of sudden hearing loss are intralabyrinthine schwannomas (ILS). The incidence of ILS is probably significantly underestimated. This may be due to the lack of awareness or lack of explicit search for an intralabyrinthine tumor on MRI or an inappropriate MRI technique ('head-MRI' instead of 'temporal bone-MRI' with too high slice thickness) for the evaluation of sudden hearing loss. Therefore, the request to the radiologist should specifically include the question for (or exclusion of) an ILS. With special MRI techniques, it is today possible to visualize an endolymphatic hydrops. The evidence in the therapy of ISSHL is - with respect to quality not quantity of studies - unsatisfying. The value of systemically (low dose) or intratympanically applied corticosteroids in the primary treatment of ISSHL is still unclear. In order to investigate the efficacy and safety of high dose corticosteroids in primary treatment for ISSHL a national, multicenter, three-armed, randomized, triple-blind controlled clinical trial is currently performed in Germany (http://hodokort-studie.hno.org/). After insufficient recovery of threshold with systemic therapy of ISSHL, intratympanic corticosteroid therapy appears to be associated with a significantly higher chance of improvement of hearing threshold than no therapy or placebo. Both, hearing gain and final hearing thresholds, however, appear to be independent of the start of secondary therapy. Based on the currently available data from clinical studies, no recommendation can be made with respect to type of corticosteroid and specifics of the intratympanic application protocol.

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“…[1][2][3]. Implantable devices have actually been used since the 1950s, when the first pacemaker was used to restore a normal heart rate by continuously pulsing only the ventricle [4]; then the evolution of implantable technology began leading to most recent implants such as Ocular and Cochlear implants [5][6][7]. Although biomedical implants do have great importance in advancing healthcare, they often require some expertise or a skilled technician to operate.…”

Section: Introductionmentioning

confidence: 99%

Wearable Skin Sensors and Their Challenges: A Review of Transdermal, Optical, and Mechanical Sensors

2020

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Wearable technology and mobile healthcare systems are both increasingly popular solutions to traditional healthcare due to their ease of implementation and cost-effectiveness for remote health monitoring. Recent advances in research, especially the miniaturization of sensors, have significantly contributed to commercializing the wearable technology. Most of the traditional commercially available sensors are either mechanical or optical, but nowadays transdermal microneedles are also being used for micro-sensing such as continuous glucose monitoring. However, there remain certain challenges that need to be addressed before the possibility of large-scale deployment. The biggest challenge faced by all these wearable sensors is our skin, which has an inherent property to resist and protect the body from the outside world. On the other hand, biosensing is not possible without overcoming this resistance. Consequently, understanding the skin structure and its response to different types of sensing is necessary to remove the scientific barriers that are hindering our ability to design more efficient and robust skin sensors. In this article, we review research reports related to three different biosensing modalities that are commonly used along with the challenges faced in their implementation for detection. We believe this review will be of significant use to researchers looking to solve existing problems within the ongoing research in wearable sensors.

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Intracochleäre Medikamentenapplikation in Verbindung mit Cochleaimplantaten

Cited by 5 publications

References 62 publications

Presbycusis: An Update on Cochlear Mechanisms and Therapies

Presbycusis: An Update on Cochlear Mechanisms and Therapies

Diagnostik und Therapie des Hörsturzes

Wearable Skin Sensors and Their Challenges: A Review of Transdermal, Optical, and Mechanical Sensors

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