Intracortical surface‐based MR diffusivity to investigate neurologic and psychiatric disorders: a review

Sampedro, Frederic; Kulisevsky, Jaime

doi:10.1111/jon.12930

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…Conversely, the GBSS-based framework used in this study provides the advantage of eliminating the requirement for smoothing. Furthermore, concerns were raised regarding the extensive computational time needed for cortical surface reconstruction with Freesurfer, as well as the necessity for rigorous quality control evaluation in surface-based analyzes ( 42 ).…”

Section: Methodsmentioning

confidence: 99%

“…The skeleton projection 1 https://github.com/daducci/AMICO the requirement for smoothing. Furthermore, concerns were raised regarding the extensive computational time needed for cortical surface reconstruction with Freesurfer, as well as the necessity for rigorous quality control evaluation in surface-based analyzes (42). GBSS was performed using the FMRIB Software Library version 6.0.3 (FSL) (43).…”

Section: Gbss Analysismentioning

confidence: 99%

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Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging

Arai,

Kamagata,

Uchida

et al. 2023

Front. Neurol.

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BackgroundCore symptoms of autism-spectrum disorder (ASD) have been associated with prefrontal cortex abnormalities. However, the mechanisms behind the observation remain incomplete, partially due to the challenges of modeling complex gray matter (GM) structures. This study aimed to identify GM microstructural alterations in adults with ASD using neurite orientation dispersion and density imaging (NODDI) and voxel-wise GM-based spatial statistics (GBSS) to reduce the partial volume effects from the white matter and cerebrospinal fluid.Materials and methodsA total of 48 right-handed participants were included, of which 22 had ASD (17 men; mean age, 34.42 ± 8.27 years) and 26 were typically developing (TD) individuals (14 men; mean age, 32.57 ± 9.62 years). The metrics of NODDI (neurite density index [NDI], orientation dispersion index [ODI], and isotropic volume fraction [ISOVF]) were compared between groups using GBSS. Diffusion tensor imaging (DTI) metrics and surface-based cortical thickness were also compared. The associations between magnetic resonance imaging-based measures and ASD-related scores, including ASD-spectrum quotient, empathizing quotient, and systemizing quotient were also assessed in the region of interest (ROI) analysis.ResultsAfter controlling for age, sex, and intracranial volume, GBSS demonstrated significantly lower NDI in the ASD group than in the TD group in the left prefrontal cortex (caudal middle frontal, lateral orbitofrontal, pars orbitalis, pars triangularis, rostral middle frontal, and superior frontal region). In the ROI analysis of individuals with ASD, a significantly positive correlation was observed between the NDI in the left rostral middle frontal, superior frontal, and left frontal pole and empathizing quotient score. No significant between-group differences were observed in all DTI metrics, other NODDI (i.e., ODI and ISOVF) metrics, and cortical thickness.ConclusionGBSS analysis was used to demonstrate the ability of NODDI metrics to detect GM microstructural alterations in adults with ASD, while no changes were detected using DTI and cortical thickness evaluation. Specifically, we observed a reduced neurite density index in the left prefrontal cortices associated with reduced empathic abilities.

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Section: Methodsmentioning

confidence: 99%

Section: Gbss Analysismentioning

confidence: 99%

Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging

Arai,

Kamagata,

Uchida

et al. 2023

Front. Neurol.

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“…Atrophy and altered microstructural integrity of the cortex can be captured with MRI outcome measures such as cortical thickness and mean diffusivity (MD), and may be a proxy of underlying neurodegeneration [25]. While PDD and DLB patients show more pronounced cortical atrophy and increased cortical MD compared to cognitively unimpaired elderly [26][27][28][29], PD patients show only subtle changes [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia

Frigerio

Laansma

Lin

et al. 2023

Transl Neurodegener

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Background Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders. In this study, we aimed to investigate the distribution of neurofilaments in the cerebral cortex of Parkinson’s disease (PD), PD with dementia (PDD) and dementia with Lewy bodies (DLB) donors, and its association with pathology load and MRI measures of atrophy and diffusivity. Methods Using a within-subject post-mortem MRI-pathology approach, we included 9 PD, 12 PDD/DLB and 18 age-matched control donors. Cortical thickness and mean diffusivity (MD) metrics were extracted respectively from 3DT1 and DTI at 3T in-situ MRI. After autopsy, pathological hallmarks (pSer129-αSyn, p-tau and amyloid-β load) together with neurofilament light-chain (NfL) and phosphorylated-neurofilament medium- and heavy-chain (p-NfM/H) immunoreactivity were quantified in seven cortical regions, and studied in detail with confocal-laser scanning microscopy. The correlations between MRI and pathological measures were studied using linear mixed models. Results Compared to controls, p-NfM/H immunoreactivity was increased in all cortical regions in PD and PDD/DLB, whereas NfL immunoreactivity was increased in the parahippocampal and entorhinal cortex in PDD/DLB. NfL-positive neurons showed degenerative morphological features and axonal fragmentation. The increased p-NfM/H correlated with p-tau load, and NfL correlated with pSer129-αSyn but more strongly with p-tau load in PDD/DLB. Lastly, neurofilament immunoreactivity correlated with cortical thinning in PD and with increased cortical MD in PDD/DLB. Conclusions Taken together, increased neurofilament immunoreactivity suggests underlying axonal injury and neurofilament accumulation in morphologically altered neurons with increased pathological burden. Importantly, we demonstrate that such neurofilament markers at least partly explain MRI measures that are associated with the neurodegenerative process.

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“…The copyright holder for this preprint this version posted August 13, 2022. ; https://doi.org/10.1101/2022.08.10.503440 doi: bioRxiv preprint Atrophy and altered microstructural integrity of the cortex can be captured with MRI outcome measures such as cortical thickness and mean diffusivity (MD), and may be a proxy of underlying neurodegeneration [56]. While PDD and DLB patients show more pronounced cortical atrophy and increased cortical MD compared to unimpaired elderly [8,12,16,64], PD patients show only subtle changes [41,57,60].…”

Section: Introductionmentioning

confidence: 99%

Cortical distribution of neurofilaments associates with pathological hallmarks and MRI measures of atrophy and diffusivity in Parkinson’s disease

Frigerio

Laansma

Lin

et al. 2022

Preprint

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Increased neurofilament levels in biofluids, commonly used as a proxy for axonal degeneration in the brain, have been found in Parkinson's disease (PD), PD with dementia (PDD) and dementia with Lewy bodies (DLB), and to correlate with MRI biomarkers. The aim of the current study was to unravel the regional distribution of cortical neurofilaments and their association with pathology load and MRI measures of atrophy and diffusivity in the post-mortem brain. Using a within-subject post-mortem MRI-pathology approach, we included 9 PD, 12 PDD/DLB and 18 age-matched control donors. Cortical thickness and mean diffusivity (MD) metrics were extracted respectively from 3DT1 and DTI at 3T in-situ MRI. After autopsy, pSer129 alpha-synuclein (pSer129-αSyn), p-tau, and amyloid-beta, together with neurofilament light-chain (NfL) and phosphorylated neurofilament medium- and heavy-chain (p-NfM/H) immunoreactivity were quantified in 7 cortical regions, and studied in detail with confocal-laser scanning microscopy. The correlations between MRI and pathological measures were studied using linear mixed models. Compared to controls, p-NfM/H immunoreactivity was increased in all cortical regions in PD and PDD/DLB, whereas NfL immunoreactivity was mainly increased in the parahippocampal and entorhinal cortex in PDD/DLB. NfL-positive neurons showed degenerative morphological features and axonal fragmentation. Increased p-NfM/H correlated with p-tau load, and NfL correlated with pSer129-αSyn but more strongly with p-tau load in PDD/DLB. Lastly, neurofilament immunoreactivity correlated with cortical thinning in PD and with increased cortical MD in PDD/DLB. Taken together, increased neurofilament immunoreactivity suggests underlying axonal injury and neurofilament accumulation in morphologically altered neurons with increasing pathological burden. Importantly, we demonstrate that such neurofilament markers at least partly explain MRI measures that are associated with the neurodegenerative process.

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Intracortical surface‐based MR diffusivity to investigate neurologic and psychiatric disorders: a review

Cited by 8 publications

References 29 publications

Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging

Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging

Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia

Cortical distribution of neurofilaments associates with pathological hallmarks and MRI measures of atrophy and diffusivity in Parkinson’s disease

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