Intracranial involvement by multiple myeloma

Lasocki, Arian; Gangatharan, Shane; Gaillard, Frank; Harrison, Simon J.

doi:10.1016/j.crad.2015.03.014

Cited by 19 publications

(16 citation statements)

References 29 publications

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“…This can be secondary to focal bone lesions or haematogenous dissemination, as in the brain. 19 MRI typically shows enhancement on the surface of the spinal cord and/or cauda equina (Figure 16). Lumbar puncture will provide the diagnosis of meningeal myelomatosis (malignant plasma cells in the cerebrospinal fluid), but if performed prior to MRI, it may cloud the MRI appearances due to post-lumbar puncture enhancement.…”

Section: Disease Complicationsmentioning

confidence: 99%

Multiple myeloma of the spine

2017

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Radiology provides a crucial clinical adjunct in patients with plasma cell disorders, in particular multiple myeloma, and its uses are evolving and expanding. This pictorial review illustrates the role of imaging throughout the patient's clinical course, with specific reference to recently updated international diagnostic criteria. At presentation, imaging optimises characterisation and staging of the plasma-cell disorder, while later in the course of the disease, its roles include the monitoring of disease progression, assessment of post-treatment response and the investigation of clinical deterioration.

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Section: Disease Complicationsmentioning

confidence: 99%

Multiple myeloma of the spine

2017

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“…7 A anemia é encontrada em 70% e a insuficiência renal por depósitos das cadeias leves ao nível dos túbulos coletores em 20% -40%. A hipercalcemia é a manifestação menos frequente, ocorrendo em 13%.…”

Section: Discussionunclassified

Vertigem como Manifestação Inaugural de Mieloma Múltiplo

Cardoso

Ribeiro

Amorim

et al. 2018

Gaz Med

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RESUMOO mieloma múltiplo é uma neoplasia maligna de células B, caracterizada pela proliferação descontrolada e clonal de plasmócitos. O envolvimento intracraniano é incomum. A vertigem e o desequilíbrio são manifestações extremamente raras e habitualmente tardias de mieloma múltiplo com extensão intracraniana. Este trabalho tem como objetivo a apresentação de um raro caso de um doente com 55 anos com queixas de vertigem como manifestação inaugural de mieloma múltiplo da fossa posterior em estádio avançado, enfatizando os aspetos clínicos, diagnósticos e terapêuticas efetuadas.

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“…Invasion of the CNS in PCL is rare and thought to be a result of a haematogenous spread [ 5 – 7 ]. The neurological manifestations are highly variable including cerebral symptoms, cranial neuropathy and spinal cord or nerve root affection [ 2 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Successful eradication of leptomeningeal plasma cell disease

Bruserud

Hansen

Vetti

et al. 2018

Oxford Medical Case Reports

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Plasma cell leukaemia (PCL) is a rare and aggressive form of malignant monoclonal gammopathy characterized by the presence of high levels of plasma cells in peripheral blood. Central nervous system involvement of PCL has no established treatment and an extremely poor prognosis. We here present a 59-year-old male patient diagnosed with PCL, initially treated with induction chemotherapy followed by autologous peripheral blood hematopoietic stem cell transplantation. After achieving a partial response, he relapsed and presented with leptomeningeal disease. He was then successfully treated with dexamethasone, pomalidomide, and an intrathecal combination of methotrexate, methylprednisolone and cytarabine. This cleared his cerebrospinal fluid from plasma cells achieving a durable partial response.

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Intracranial involvement by multiple myeloma

Cited by 19 publications

References 29 publications

Multiple myeloma of the spine

Multiple myeloma of the spine

Vertigem como Manifestação Inaugural de Mieloma Múltiplo

Successful eradication of leptomeningeal plasma cell disease

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