Intradermal pollen therapy during the attack

Specific Hyposensitization of Patients With Penicillin Allergy

“…However, a multitude of studies have substantiated the efficacy of the hyposensitization. In the early papers improvement by specific hyposensitization was reported in 80-90 per cent of pollen allergies (14,54,71). Similar results have been obtained in asthmatics by hyposensitization with other antigens (12,28).…”

“…In the early papers improvement by specific hyposensitization was reported in 80-90 per cent of pollen allergies (14,54,71). In the early papers improvement by specific hyposensitization was reported in 80-90 per cent of pollen allergies (14,54,71).…”

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses

“…To our knowledge, this phenomenon of intradermal injection with low-dose allergen extracts has not been readdressed since the work of Phillips. 10 In a previous clinical study of allergen immunotherapy, we unexpectedly observed a tendency in placebo-treated participants for the size of the cutaneous late response induced by intradermal allergen challenge to diminish when repeated on multiple occasions. 7 The present study, which was prospectively designed to investigate this phenomenon under controlled conditions, confirms that repeated low-dose intradermal injection of grass pollen allergen is associated with suppression of the cutaneous late response elicited in response to this provocation.…”

Intradermal immunotherapy with low-dose house dust mite allergens in patients with allergic rhinitis: A proof-of-concept study

“…There are very few studies employing the IDIT technique 19,20,21,22,23,24,25 and none, known to us, with HDM allergens. Doses employed in previous reports of IDIT with grass pollen were guided by the suppression of late cutaneous reactions, 22,25 with cu- mulative doses reaching 1000 fold less allergen vs conventional SCIT over a year´s time (nanograms vs micrograms); furthermore, in these studies, injections were given every two weeks for three months and spaced out afterwards.…”