Intradermal substance P as a challenge agent in healthy individuals
Wouter ten Voorde,
Chika Akinseye,
Ismahaan Abdisalaam
et al.
Abstract:Pharmacological challenge models are deployed to evaluate drug effects during clinical development. Intradermal injection of Substance P (SP) neuropeptide, a potential challenge agent for investigating local mediators, is associated with wheal and flare response mediated by the MRGPRX2 receptor. Although dose‐dependent data on SP effects exist, full characterization and information on potential carryover effect after repeated challenge are lacking. This open‐label, two‐part, prospective enabling study of SP in… Show more
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