2016
DOI: 10.1016/j.vaccine.2015.12.058
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Intradermal vaccination with un-adjuvanted sub-unit vaccines triggers skin innate immunity and confers protective respiratory immunity in domestic swine

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Cited by 20 publications
(23 citation statements)
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“…Induction of mucosal immune responses by influenza vaccines would be advantageous, because these responses could control or limit virus replication in the respiratory tract [40]. ID or MAP immunisation has been shown to induce mucosal responses to nonlive vaccines including influenza in mice and swine [17,[41][42][43]. In humans, however, ID delivery of IIVs Frequency of CD4 + cells producing IL-2, TNF-α, or IFN-γ following stimulation of PBMC with (A) overlapping peptides spanning A/Sing HA (5 μg/ml) or (B) A/Sing MPH (20 μg/ml).…”
Section: Discussionmentioning
confidence: 99%
“…Induction of mucosal immune responses by influenza vaccines would be advantageous, because these responses could control or limit virus replication in the respiratory tract [40]. ID or MAP immunisation has been shown to induce mucosal responses to nonlive vaccines including influenza in mice and swine [17,[41][42][43]. In humans, however, ID delivery of IIVs Frequency of CD4 + cells producing IL-2, TNF-α, or IFN-γ following stimulation of PBMC with (A) overlapping peptides spanning A/Sing HA (5 μg/ml) or (B) A/Sing MPH (20 μg/ml).…”
Section: Discussionmentioning
confidence: 99%
“… 9 More recently, we showed that ID vaccination with viral glycoproteins protected domestic swine against a lethal respiratory infection with a porcine herpes virus, as efficiently as intramuscular vaccination with the gold standard. 10 Yet, similar to other parenteral routes of immunisation, the ID route seems to be poorly efficient at inducing mucosal Abs, especially IgA, even in the presence of adjuvants such as the double mutant of heat-labile Escherichia coli enterotoxin dmLT, 11–13 the Toll-like receptor ligand (TLR-L)-4 monophosphoryl lipid A 14 or thymic stromal lymphopoietin. 15 This highlights the need to identify ID adjuvants suitable to elicit mucosal immunity.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, the formation of granuloma or fibrosis in the muscle could be excluded in the needle-free ID vaccination herds. A previous report showed that ID FMD vaccination using the same antigen payload as that used for IM vaccination effectively protected the pigs from FMDVs [11]. The ID vaccination group (G1, G2, G3) had significantly higher PI values in the type O SP ELISA or VN titers than the control group.…”
Section: Discussionmentioning
confidence: 98%
“…The protective immunity shown in G3 could not be explained plainly by the humoral immunity compared to G4; it is reported that, when compared to IM vaccination, ID vaccination enables the protection of animals when their VNT antibody titers are low [11]. Whilst this effect is partly associated with the humoral immunity, ID vaccination is a major contributor to cell-mediated immune responses that induce the mobilization of inflammatory dendritic cells [1124].…”
Section: Discussionmentioning
confidence: 99%
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