INTRAGASTRIC pH CONTROL ON TWICE DAILY PROTON PUMP INHIBITORS (PPIS). IS A PPIA PPI?

Lehrer, Jenifer K.; Zavala, Stacey; Braitman, Leonard E.; Gideon, R. Matthew; Castell, Donald O.; Katz, Philip O.

doi:10.14309/00000434-200410001-00115

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“…PPI dosing found rabeprazole and esomeprazole produced more time with intragastric pH >4 than did pantoprazole or lansoprazole. 16 In these studies, the first day of treatment (day 1) was not studied. In this present study, intragastric pH was >4 for 14.1 h and 14.7 h in the proximal and mid/distal stomach, respectively on day 1 of rabeprazole 20 mg and 17.1 h and 13.2 h, respectively on day 8 of rabeprazole treatment; these compare with only 3 h and 0 h in the proximal and mid/distal stomach, respectively on day 1 of placebo and 3.8 h and 0.72 h, respectively on day 8 of placebo treatment.…”

Section: Discussionmentioning

confidence: 99%

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The effect of rabeprazole on regional gastric acidity and the postprandial cardia/gastro‐oesophageal junction acid layer in normal subjects: a randomized, double‐blind, placebo‐controlled study

Simonian

Doma

et al. 2005

Aliment Pharmacol Ther

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SUMMARYBackground: Postprandial intragastric acidity is not uniform. Postprandial proximal gastric acid pockets have been described in the present study. Aim: To determine the effects of rabeprazole on regional intragastric acidity and proximal acid pockets. Methods: Ten normal subjects underwent two 8-day oral dosing regimens with placebo or rabeprazole 20 mg each morning in a randomized, double-blind protocol. Oesophago-gastric pH monitoring was performed on days 1 and 8. Results: Rabeprazole increased fasting and postprandial gastric pH to above 4 in each area of the stomach on days 1 and 8. With placebo, acid pockets were identified

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Section: Discussionmentioning

confidence: 99%

“…Another study using b.d. PPI dosing found rabeprazole and esomeprazole produced more time with intragastric pH >4 than did pantoprazole or lansoprazole 16 . In these studies, the first day of treatment (day 1) was not studied.…”

Section: Discussionmentioning

confidence: 99%

The effect of rabeprazole on regional gastric acidity and the postprandial cardia/gastro‐oesophageal junction acid layer in normal subjects: a randomized, double‐blind, placebo‐controlled study

Simonian

Doma

et al. 2005

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

INTRAGASTRIC pH CONTROL ON TWICE DAILY PROTON PUMP INHIBITORS (PPIS). IS A PPIA PPI?

Cited by 1 publication

References 0 publications

The effect of rabeprazole on regional gastric acidity and the postprandial cardia/gastro‐oesophageal junction acid layer in normal subjects: a randomized, double‐blind, placebo‐controlled study

The effect of rabeprazole on regional gastric acidity and the postprandial cardia/gastro‐oesophageal junction acid layer in normal subjects: a randomized, double‐blind, placebo‐controlled study

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