Intraindividual changes in theophylline clearance during constant aminophylline infusion in children with acute asthma

Kubo, Mariko; Odajima, Yasuhei; Ishizaki, Takashi; Kanagawa, Shuzoh; Yamaguchi, M.; Nagai, Tsuneji

doi:10.1016/s0022-3476(86)80951-9

Cited by 25 publications

(10 citation statements)

References 15 publications

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“…In the non‐infected group, serum theophylline levels were decreased over time during 72 h infusion, despite the constant infusion rate. Kubo et al reported similar finding and listed several candidates such as dehydration, hypoxia, and acidosis, but they could not find any association between these candidates and theophylline clearance 20 . In the present study there were no differences between the two groups regarding these factors.…”

Section: Discussionsupporting

confidence: 47%

Theophylline metabolism in acute asthma with MxA‐indicated viral infection

Itazawa

Adachi

Nakabayashi

et al. 2006

Pediatrics International

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Section: Discussionsupporting

confidence: 47%

Theophylline metabolism in acute asthma with MxA‐indicated viral infection

Itazawa

Adachi

Nakabayashi

et al. 2006

Pediatrics International

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“…In addition, Kubo et al 20) reported that appreciable changes in theophylline clearance could occur in children with acute asthma within a few days (at least 72 h). Therefore, the theophylline concentration within 48 h after the initiation of continuous aminophylline infusion was defined as the concentration at asthmatic acute phase and the subject was enrolled.…”

Section: Patients and Data Selectionmentioning

confidence: 99%

Effect of Gender on Theophylline Clearance in the Asthmatic Acute Phase in Japanese Pediatric Patients

Igarashi

Iwakawa

2009

Biological & Pharmaceutical Bulletin

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The effect of gender on theophylline clearance was investigated retrospectively in 96 Japanese pediatric patients (63 males and 33 females) ranging in age from 0.5 to 8 years and in weight from 6.3 to 36.8 kg. All patients received intravenous constant-rate infusion of aminophylline in the asthmatic acute phase. The theophylline clearances in males and females were 56.2؎15.4 and 50.1؎14.2 ml/h/kg for ages 0.5-Ͻ2 years, 58.7؎18.8 and 48.3؎6.5 ml/h/kg for ages 2-Ͻ4 years, and 65.7؎12.0 and 52.1؎16.8 ml/h/kg for ages 4-Ͻ9 years, respectively. At ages from 2 to 8 years, the theophylline clearance was 20% higher in males than in females (pϽ0.05). Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants.

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“…Theophylline clearance rates were calculated from the formula; Clearance (ml/kg per hour = R/Cpss, where R is the infusion rate of theophylline (gg/kg per hour) and Cpss is the steady state theophylline level (gg/ml). We used the 24 h theophylline level to represent the steady state in this calculation [3]. .wr :.…”

Section: Methodsmentioning

confidence: 99%