Intralesional steroid injection after endoscopic balloon dilation in pediatric Crohn's disease with stricture: a prospective, randomized, double-blind, controlled trial

Nardo, Giovanni Di; Oliva, Salvatore; Passariello, Maurizio; Pallotta, Nadia; Civitelli, Fortunata; Frediani, Simone; Gualdi, Gianfranco; Gandullia, Paolo; Mallardo, Saverio; Cucchiara, Salvatore

doi:10.1016/j.gie.2010.08.003

Cited by 113 publications

(74 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Long strictures (> 3 cm) were associated to negative outcome in 6/7 patients. 35 Some authors advocate injecting corticosteroids into the stenotic bowel segment after balloon dilation 36 , but long-term effect has not univocally been confirmed and more prospective studies are needed. 37 Symptom recurrence after endoscopic balloon dilation has been reported in 13-100% of patients.…”

Section: A B C Dmentioning

confidence: 99%

Interventional balloon-enteroscopy

Albert¹

2012

jig

View full text Add to dashboard Cite

Section: A B C Dmentioning

confidence: 99%

Interventional balloon-enteroscopy

Albert¹

2012

jig

View full text Add to dashboard Cite

“…The results are much better in the pediatric group than in adults, warranting additional studies before a firm evidence-based 38 128 83 3 33 recommendation could be made. 52,53 There are anecdotal reports of efficacy of submucosal injection of infliximab in combination with EBD in Crohn's strictures. 54,55 However, there is currently no clear evidence supporting this therapeutic intervention.…”

Section: Intralesional Drug Injectionmentioning

confidence: 99%

Endoscopy in the Diagnosis and Management of Complications of Inflammatory Bowel Disease

Tharian

George

Navaneethan

2016

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

The role of endoscopy in inflammatory bowel disease (IBD) has grown over the last decade in both diagnostic and therapeutic realms. It aids in the initial diagnosis of the disease and also in the assessment of the extent and severity of disease. IBD is associated with development of multiple complications such as strictures, fistulae, and colon cancers. Endoscopy plays a pivotal role in the diagnosis of colon cancer in patients with IBD through incorporation of chromoendoscopy for surveillance. In addition, endoscopic resection with surveillance is recommended in the management of polypoid dysplastic lesions without flat dysplasia. IBD-associated benign strictures with obstructive symptoms amenable to endoscopic intervention can be managed with endoscopic balloon dilation both in the colon and small intestine. In addition, endoscopy plays a major role in assessing the neoterminal ileum after surgery to risk-stratify patients after ileocolonic resection and assessment of a patient with ileoanal pouch anastomosis surgery and management of postsurgical complications. Our article summarizes the current evidence in the role of endoscopy in the diagnosis and management of complications of IBD.

show abstract

“…Based on the successful experience on other stricturing conditions (peptic, corrosive, postradiotherapy and surgical strictures), retrospective studies on lower gastrointestinal CD strictures have shown that triamcinolone injection can delay the time of redilation and reduce the recurrence rate [41,42]. In a prospective study on pediatric CD patients, steroid injection after ED was shown to increase the dilationfree interval and delay surgery in the short term compared with placebo [43]. However, in a pilot controlled study on adult CD patients, steroid injection failed to reduce time to redilation and showed a trend to a worse outcome compared with placebo [44].…”

Section: Adjuvant Techniques To Tts Ballon Dilationmentioning

confidence: 99%

Endoscopic treatment of Crohn’s complications

Buda

Okolo

2014

Expert Review of Gastroenterology & Hepatology

View full text Add to dashboard Cite

The progression to fistula and strictures is part of the natural history of Crohn's disease (CD) and these complications negatively affect the quality of life of CD patients. Surgery is the traditional treatment of CD strictures. However, due the chronicity of the inflammatory process and the associated fibrosis, postoperative recurrence occurs frequently. The lack of specific drug to treat fibrotic strictures and their irreversible nature has drawn the attention to less invasive and bowel-sparing therapeutic modalities. Endoluminal therapies may provide effective option in relieving symptoms associated with CD complications and reduce the need for repeated surgery with substantial clinical benefit. This review will discuss the current use and efficacy of the endoscopic treatment of CD complications. New endoscopic modalities and recent advances will be also evaluated.

show abstract

Intralesional steroid injection after endoscopic balloon dilation in pediatric Crohn's disease with stricture: a prospective, randomized, double-blind, controlled trial

Cited by 113 publications

References 36 publications

Interventional balloon-enteroscopy

Interventional balloon-enteroscopy

Endoscopy in the Diagnosis and Management of Complications of Inflammatory Bowel Disease

Endoscopic treatment of Crohn’s complications

Contact Info

Product

Resources

About